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Protein

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Gene

b3gat2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseImported, Transferase
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT43. Glycosyltransferase Family 43.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferaseUniRule annotation (EC:2.4.1.135UniRule annotation)
Gene namesi
Name:b3gat2Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

  • Golgi apparatus membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatusUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ599K1.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027741.

Structurei

3D structure databases

ProteinModelPortaliQ599K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 43 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1476. Eukaryota.
ENOG410XP79. LUCA.
HOGENOMiHOG000261693.
HOVERGENiHBG050650.
KOiK10157.

Family and domain databases

CDDicd00218. GlcAT-I. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR005027. Glyco_trans_43.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR10896. PTHR10896. 1 hit.
PfamiView protein in Pfam
PF03360. Glyco_transf_43. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q599K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSVLFSRFF MLLPWILIVI IMLDVDTRRP TPPLTPRPYF APYSGGRGGA
60 70 80 90 100
RLPLRRGGPG RGREPRNESW PRPPPPPPEP PLPTIYAITP TYSRPVQKAE
110 120 130 140 150
LTRLANTFRQ VAQLHWILVE DAAARSELVS RFLARAGLPS THLHVPTPRR
160 170 180 190 200
YKRPGLPRAT EQRNAGLAWL RQRHGHQRAQ PGVLFFADDD NTYSLELFQE
210 220 230 240 250
MRTTRKVSVW PVGLVGGRRY ERPLVENGKV VGWYTGWRAD RPFAIDMAGF
260 270 280 290 300
AVSLQVILSN PKAVFKRRGS QPGMQESDFL RQITTVEELE PKANNCTKVL
310 320
VWHTRTEKVN LANEPKYHLD TVTIDV
Length:326
Mass (Da):37,145
Last modified:April 26, 2005 - v1
Checksum:i79ABC47A6177FA73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ890840 mRNA. Translation: CAI68026.1.
RefSeqiNP_001014414.1. NM_001014392.1.
UniGeneiBt.37460.

Genome annotation databases

GeneIDi541595.
KEGGibta:541595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ890840 mRNA. Translation: CAI68026.1.
RefSeqiNP_001014414.1. NM_001014392.1.
UniGeneiBt.37460.

3D structure databases

ProteinModelPortaliQ599K1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027741.

Protein family/group databases

CAZyiGT43. Glycosyltransferase Family 43.

Proteomic databases

PaxDbiQ599K1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi541595.
KEGGibta:541595.

Organism-specific databases

CTDi135152.

Phylogenomic databases

eggNOGiKOG1476. Eukaryota.
ENOG410XP79. LUCA.
HOGENOMiHOG000261693.
HOVERGENiHBG050650.
KOiK10157.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

CDDicd00218. GlcAT-I. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR005027. Glyco_trans_43.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR10896. PTHR10896. 1 hit.
PfamiView protein in Pfam
PF03360. Glyco_transf_43. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ599K1_BOVIN
AccessioniPrimary (citable) accession number: Q599K1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 7, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.