Reviewed, UniProtKB/Swiss-Prot Q599A1 (COX1_BALBO)

Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I

Gene names

Name:	MT-CO1
Synonyms:	COI, COXI, MTCO1

Encoded on

Mitochondrion

Organism

Balaenoptera borealis (Sei whale) (Pollack whale)

Taxonomic identifier

9768 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Cetacea › Mysticeti › Balaenopteridae › Balaenoptera

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Pathway	Energy metabolism; oxidative phosphorylation.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the heme-copper respiratory oxidase family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Ligand	Copper Heme Iron Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	aerobic respiration Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 516	516	Cytochrome c oxidase subunit 1		PRO_0000261575
Regions
	Transmembrane	17 – 37	21	Potential
	Transmembrane	63 – 83	21	Potential
	Transmembrane	102 – 122	21	Potential
	Transmembrane	145 – 165	21	Potential
	Transmembrane	183 – 203	21	Potential
	Transmembrane	234 – 254	21	Potential
	Transmembrane	268 – 288	21	Potential
	Transmembrane	310 – 330	21	Potential
	Transmembrane	338 – 358	21	Potential
	Transmembrane	380 – 400	21	Potential
	Transmembrane	412 – 432	21	Potential
	Transmembrane	456 – 476	21	Potential
Sites
	Metal binding	61	1	Iron (heme A axial ligand) Probable
	Metal binding	240	1	Copper B Probable
	Metal binding	244	1	Copper B Probable
	Metal binding	290	1	Copper B Probable
	Metal binding	291	1	Copper B Probable
	Metal binding	376	1	Iron (heme A3 axial ligand) Probable
	Metal binding	378	1	Iron (heme A axial ligand) Probable
Amino acid modifications
	Cross-link	240 ↔ 244		1'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q599A1-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 723705C0A667EBEB	FASTA	516	57,195
	10 20 30 40 50 60 MFMNRWLFST NHKDIGTLYL LFGAWAGMVG TGLSLLIRAE LGQPGTLIGD DQVYNVLVTA 70 80 90 100 110 120 HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSFL LLMASSMVEA 130 140 150 160 170 180 GAGTGWTVYP PLAGNLAHAG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ 190 200 210 220 230 240 TPLFVWSVLV TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH 250 260 270 280 290 300 PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMVSI GFLGFIVWAH HMFTVGMDVD 310 320 330 340 350 360 TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPALMW ALGFIFLFTV GGLTGIVLAN 370 380 390 400 410 420 SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFVHWFPLF SGYTLNTTWA KIHFMIMFVG 430 440 450 460 470 480 VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NTISSMGSFI SLTAVMLMIF IIWEAFTSKR 490 500 510 EVLAVDLTST NLEWLNGCPP PYHTFEEPAF VNPKWS

References

[1]	"Mitochondrial phylogenetics and evolution of mysticete whales." Sasaki T., Nikaido M., Hamilton H., Goto M., Kato H., Kanda N., Pastene L.A., Cao Y., Fordyce R.E., Hasegawa M., Okada N. Syst. Biol. 54:77-90(2005) [PubMed: 15805012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006470 Genomic DNA. Translation: BAD91722.1.
RefSeq	YP_220747.1.
3D structure databases
HSSP	HSSP built from PDB template 2OCC based on UniProtKB P00396.
SMR	Q599A1. Positions 1-514.
ModBase	Search...
Genome annotation databases
GeneID	3337157.
Organism-specific databases
CTD	3337157.
Phylogenomic databases
HOVERGEN	Q599A1.
Enzyme and pathway databases
BRENDA	1.9.3.1. 292314.
Family and domain databases
InterPro	IPR000883. Cyt_c_oxidase_su1. [Graphical view]
Gene3D	G3DSA:1.20.210.10. COX1. 1 hit.
PANTHER	PTHR10422. COX1. 1 hit.
Pfam	PF00115. COX1. 1 hit. [Graphical view]
PRINTS	PR01165. CYCOXIDASEI.
PROSITE	PS50855. COX1. 1 hit. PS00077. COX1_CUB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX1_BALBO

Accession

Primary (citable) accession number: Q599A1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	April 26, 2005
Last modified:	November 24, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)