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Protein

Zinc-transporting ATPase

Gene

ziaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + Zn2+(In) = ADP + phosphate + Zn2+(Out).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191ZincPROSITE-ProRule annotation
Metal bindingi22 – 221ZincPROSITE-ProRule annotation
Active sitei425 – 42514-aspartylphosphate intermediateBy similarity
Metal bindingi618 – 6181MagnesiumPROSITE-ProRule annotation
Metal bindingi622 – 6221MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-transporting ATPase (EC:3.6.3.5)
Alternative name(s):
Zn(2+)-translocating P-type ATPase
Gene namesi
Name:ziaA
Ordered Locus Names:slr0798
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 107107CytoplasmicBy similarityAdd
BLAST
Transmembranei108 – 12821HelicalBy similarityAdd
BLAST
Topological domaini129 – 14012ExtracellularBy similarityAdd
BLAST
Transmembranei141 – 16020HelicalBy similarityAdd
BLAST
Topological domaini161 – 1677CytoplasmicBy similarity
Transmembranei168 – 18720HelicalBy similarityAdd
BLAST
Topological domaini188 – 1903ExtracellularBy similarity
Transmembranei191 – 21020HelicalBy similarityAdd
BLAST
Topological domaini211 – 344134CytoplasmicBy similarityAdd
BLAST
Transmembranei345 – 36319HelicalBy similarityAdd
BLAST
Topological domaini364 – 3696ExtracellularBy similarity
Transmembranei370 – 38718HelicalBy similarityAdd
BLAST
Topological domaini388 – 671284CytoplasmicBy similarityAdd
BLAST
Transmembranei672 – 69322HelicalBy similarityAdd
BLAST
Topological domaini694 – 7018ExtracellularBy similarity
Transmembranei702 – 71716HelicalBy similarityAdd
BLAST
Topological domaini718 – 7214CytoplasmicBy similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Zinc-transporting ATPasePRO_0000046333Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiQ59998. 25 interactions.

Structurei

Secondary structure

1
721
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 158Combined sources
Helixi21 – 233Combined sources
Helixi24 – 274Combined sources
Helixi29 – 324Combined sources
Beta strandi34 – 429Combined sources
Turni43 – 464Combined sources
Beta strandi47 – 526Combined sources
Turni54 – 563Combined sources
Helixi60 – 678Combined sources
Turni68 – 703Combined sources
Beta strandi72 – 743Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LDINMR-A6-76[»]
2OFGNMR-X1-111[»]
2OFHNMR-X1-111[»]
ProteinModelPortaliQ59998.
SMRiQ59998. Positions 6-111.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59998.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 7567HMAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250399.
InParanoidiQ59998.
KOiK01534.
OMAiMWEAIFA.
OrthoDBiEOG6742RM.
PhylomeDBiQ59998.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSSPLKTQ QMQVGGMDCT SCKLKIEGSL ERLKGVAEAS VTVATGRLTV
60 70 80 90 100
TYDPKQVSEI TIQERIAALG YTLAEPKSSV TLNGHKHPHS HREEGHSHSH
110 120 130 140 150
GAGEFNLKQE LLPVLTAIAL FTIAILFEQP LHNTPGQIAE FAVIIPAYLL
160 170 180 190 200
SGWTVLKTAG RNILRGQIFD ENFLMTIATL GALAIHQLPE AVAVMLFFRV
210 220 230 240 250
GELFQEYSVG RSRRSIKALL EARPDTANLK RNGTVQQVSP ETVQVDDLIL
260 270 280 290 300
VKPGEKVPLD GEILGGTSQV DTSALTGESV PGTVKPGDTI LAGMINQSGV
310 320 330 340 350
LTIRVTKLFS ESSIAKVLDL VENASSKKAS TEKFITQFAR YYTPVIVFLS
360 370 380 390 400
LAVALLPPLF IPGADRADWV YRALVLLVIS CPCGLVISIP LGYFGGIGGA
410 420 430 440 450
AKHGILIKGS TFLDSLTAVK TVVFDKTGTL TKGTFKVTQV VTKNGFSESE
460 470 480 490 500
LLTLAAKAES HSTHPIALSI REAYAQSIAD SEVADYEEIA GHGIRAVVQN
510 520 530 540 550
QVVIAGNDRL LHREKIDHDT CDVAGTVVHL AVDGRYGGYI LIADEIKEDA
560 570 580 590 600
VQAIRDLKRM GVEKTVMLTG DSEIVAQSVA QQIGLDAFVA ELLPEEKVDE
610 620 630 640 650
IEQLLDPSGK AKLAFVGDGI NDAPVIARAD VGIAMGGLGS DAAIETADVV
660 670 680 690 700
LMTDAPSKVA EAIHVARKTR QIVVQNIVLA LGIKALFIAL GTIGLATLWE
710 720
AVFADVGVAL LAILNATRIA K
Length:721
Mass (Da):76,884
Last modified:November 1, 1996 - v1
Checksum:iBE187EB3900EC58B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10707.1.
PIRiS77015.

Genome annotation databases

EnsemblBacteriaiBAA10707; BAA10707; BAA10707.
KEGGisyn:slr0798.
PATRICi23843016. VBISynSp132158_3046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10707.1.
PIRiS77015.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LDINMR-A6-76[»]
2OFGNMR-X1-111[»]
2OFHNMR-X1-111[»]
ProteinModelPortaliQ59998.
SMRiQ59998. Positions 6-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ59998. 25 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10707; BAA10707; BAA10707.
KEGGisyn:slr0798.
PATRICi23843016. VBISynSp132158_3046.

Phylogenomic databases

HOGENOMiHOG000250399.
InParanoidiQ59998.
KOiK01534.
OMAiMWEAIFA.
OrthoDBiEOG6742RM.
PhylomeDBiQ59998.

Miscellaneous databases

EvolutionaryTraceiQ59998.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter."
    Thelwell C., Robinson N.J., Turner-Cavet J.S.
    Proc. Natl. Acad. Sci. U.S.A. 95:10728-10733(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiATZN_SYNY3
AccessioniPrimary (citable) accession number: Q59998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.