Zinc-transporting ATPase - Synechocystis sp. (strain PCC 6803 / Kazusa)

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Q59998 (ATZN_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc-transporting ATPase
EC=3.6.3.5

Alternative name(s):
Zn(2+)-translocating P-type ATPase

Gene names

Name:	ziaA
Ordered Locus Names:	slr0798

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	721 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity

ATP + H₂O + Zn²⁺(In) = ADP + phosphate + Zn²⁺(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Contains 1 HMA domain.

Ontologies

Keywords
Biological process	Ion transport Transport Zinc transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cation channel activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc-exporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 721

721

Zinc-transporting ATPase

PRO_0000046333

Regions

Topological domain

1 – 107

107

Cytoplasmic By similarity

Transmembrane

108 – 128

Helical; By similarity

Topological domain

129 – 140

Extracellular By similarity

Transmembrane

141 – 160

Helical; By similarity

Topological domain

161 – 167

Cytoplasmic By similarity

Transmembrane

168 – 187

Helical; By similarity

Topological domain

188 – 190

Extracellular By similarity

Transmembrane

191 – 210

Helical; By similarity

Topological domain

211 – 344

134

Cytoplasmic By similarity

Transmembrane

345 – 363

Helical; By similarity

Topological domain

364 – 369

Extracellular By similarity

Transmembrane

370 – 387

Helical; By similarity

Topological domain

388 – 671

284

Cytoplasmic By similarity

Transmembrane

672 – 693

Helical; By similarity

Topological domain

694 – 701

Extracellular By similarity

Transmembrane

702 – 717

Helical; By similarity

Topological domain

718 – 721

Cytoplasmic By similarity

Domain

9 – 75

HMA

Sites

Active site

425

4-aspartylphosphate intermediate By similarity

Metal binding

Zinc Potential

Metal binding

Zinc Potential

Metal binding

618

Magnesium By similarity

Metal binding

622

Magnesium By similarity

Secondary structure

721

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q59998 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BE187EB3900EC58B
Show »

FASTA

721

76,884

        10         20         30         40         50         60 
MTQSSPLKTQ QMQVGGMDCT SCKLKIEGSL ERLKGVAEAS VTVATGRLTV TYDPKQVSEI 

        70         80         90        100        110        120 
TIQERIAALG YTLAEPKSSV TLNGHKHPHS HREEGHSHSH GAGEFNLKQE LLPVLTAIAL 

       130        140        150        160        170        180 
FTIAILFEQP LHNTPGQIAE FAVIIPAYLL SGWTVLKTAG RNILRGQIFD ENFLMTIATL 

       190        200        210        220        230        240 
GALAIHQLPE AVAVMLFFRV GELFQEYSVG RSRRSIKALL EARPDTANLK RNGTVQQVSP 

       250        260        270        280        290        300 
ETVQVDDLIL VKPGEKVPLD GEILGGTSQV DTSALTGESV PGTVKPGDTI LAGMINQSGV 

       310        320        330        340        350        360 
LTIRVTKLFS ESSIAKVLDL VENASSKKAS TEKFITQFAR YYTPVIVFLS LAVALLPPLF 

       370        380        390        400        410        420 
IPGADRADWV YRALVLLVIS CPCGLVISIP LGYFGGIGGA AKHGILIKGS TFLDSLTAVK 

       430        440        450        460        470        480 
TVVFDKTGTL TKGTFKVTQV VTKNGFSESE LLTLAAKAES HSTHPIALSI REAYAQSIAD 

       490        500        510        520        530        540 
SEVADYEEIA GHGIRAVVQN QVVIAGNDRL LHREKIDHDT CDVAGTVVHL AVDGRYGGYI 

       550        560        570        580        590        600 
LIADEIKEDA VQAIRDLKRM GVEKTVMLTG DSEIVAQSVA QQIGLDAFVA ELLPEEKVDE 

       610        620        630        640        650        660 
IEQLLDPSGK AKLAFVGDGI NDAPVIARAD VGIAMGGLGS DAAIETADVV LMTDAPSKVA 

       670        680        690        700        710        720 
EAIHVARKTR QIVVQNIVLA LGIKALFIAL GTIGLATLWE AVFADVGVAL LAILNATRIA 


K

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[3]	"An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter." Thelwell C., Robinson N.J., Turner-Cavet J.S. Proc. Natl. Acad. Sci. U.S.A. 95:10728-10733(1998) [PubMed: 9724772] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000022 Genomic DNA. Translation: BAA10707.1.

PIR

S77015.

RefSeq

NP_442636.1. NC_000911.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LDI	NMR	-	A	6-76	[»]
2OFG	NMR	-	X	1-111	[»]
2OFH	NMR	-	X	1-111	[»]

ProteinModelPortal

Q59998.

SMR

Q59998. Positions 6-111.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q59998. 27 interactions.

STRING

Q59998.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

952488.

GenomeReviews

Gene locus slr0798 in contig BA000022_GR.

KEGG

syn:slr0798.

NMPDR

fig|1148.1.peg.2737.

PATRIC

23843016. VBISynSp132158_3046.

Phylogenomic databases

eggNOG

COG2217.

HOGENOM

HBG507745.

OMA

INYAMKT.

PhylomeDB

Q59998.

ProtClustDB

CLSK342750.

Enzyme and pathway databases

BioCyc

SSP1148:SLR0798-MONOMER.

Family and domain databases

InterPro

IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR001366. ATPase_P-typ_Cd-transp.
IPR006404. ATPase_P-typ_Cd/Co/Hg/Pb/Zn.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR006416. ATPase_P-typ_heavy-metal.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
[Graphical view]

Gene3D

G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.

K01534.

Pfam

PF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]

PRINTS

PR00119. CATATPASE.
PR00941. CDATPASE.

SUPFAM

SSF56784. HAD-like_dom. 1 hit.
SSF55008. HeavyMe_transpt. 1 hit.

TIGRFAMs

TIGR01512. ATPase-IB2_Cd. 1 hit.
TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.

PROSITE

PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

ATZN_SYNY3

Accession

Primary (citable) accession number: Q59998

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents