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Protein

Zinc-transporting ATPase

Gene

ziaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + Zn2+(In) = ADP + phosphate + Zn2+(Out).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincPROSITE-ProRule annotation1
Metal bindingi22ZincPROSITE-ProRule annotation1
Active sitei4254-aspartylphosphate intermediateBy similarity1
Metal bindingi618MagnesiumPROSITE-ProRule annotation1
Metal bindingi622MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-transporting ATPase (EC:3.6.3.5)
Alternative name(s):
Zn(2+)-translocating P-type ATPase
Gene namesi
Name:ziaA
Ordered Locus Names:slr0798
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 107CytoplasmicBy similarityAdd BLAST107
Transmembranei108 – 128HelicalBy similarityAdd BLAST21
Topological domaini129 – 140ExtracellularBy similarityAdd BLAST12
Transmembranei141 – 160HelicalBy similarityAdd BLAST20
Topological domaini161 – 167CytoplasmicBy similarity7
Transmembranei168 – 187HelicalBy similarityAdd BLAST20
Topological domaini188 – 190ExtracellularBy similarity3
Transmembranei191 – 210HelicalBy similarityAdd BLAST20
Topological domaini211 – 344CytoplasmicBy similarityAdd BLAST134
Transmembranei345 – 363HelicalBy similarityAdd BLAST19
Topological domaini364 – 369ExtracellularBy similarity6
Transmembranei370 – 387HelicalBy similarityAdd BLAST18
Topological domaini388 – 671CytoplasmicBy similarityAdd BLAST284
Transmembranei672 – 693HelicalBy similarityAdd BLAST22
Topological domaini694 – 701ExtracellularBy similarity8
Transmembranei702 – 717HelicalBy similarityAdd BLAST16
Topological domaini718 – 721CytoplasmicBy similarity4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463331 – 721Zinc-transporting ATPaseAdd BLAST721

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ59998.

Interactioni

Protein-protein interaction databases

IntActiQ59998. 25 interactors.

Structurei

Secondary structure

1721
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 15Combined sources8
Helixi21 – 23Combined sources3
Helixi24 – 27Combined sources4
Helixi29 – 32Combined sources4
Beta strandi34 – 42Combined sources9
Turni43 – 46Combined sources4
Beta strandi47 – 52Combined sources6
Turni54 – 56Combined sources3
Helixi60 – 67Combined sources8
Turni68 – 70Combined sources3
Beta strandi72 – 74Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LDINMR-A6-111[»]
2OFGNMR-X1-111[»]
2OFHNMR-X1-111[»]
ProteinModelPortaliQ59998.
SMRiQ59998.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59998.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 75HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Contains 1 HMA domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250399.
InParanoidiQ59998.
KOiK01534.
OMAiIKEDAKQ.
PhylomeDBiQ59998.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQSSPLKTQ QMQVGGMDCT SCKLKIEGSL ERLKGVAEAS VTVATGRLTV
60 70 80 90 100
TYDPKQVSEI TIQERIAALG YTLAEPKSSV TLNGHKHPHS HREEGHSHSH
110 120 130 140 150
GAGEFNLKQE LLPVLTAIAL FTIAILFEQP LHNTPGQIAE FAVIIPAYLL
160 170 180 190 200
SGWTVLKTAG RNILRGQIFD ENFLMTIATL GALAIHQLPE AVAVMLFFRV
210 220 230 240 250
GELFQEYSVG RSRRSIKALL EARPDTANLK RNGTVQQVSP ETVQVDDLIL
260 270 280 290 300
VKPGEKVPLD GEILGGTSQV DTSALTGESV PGTVKPGDTI LAGMINQSGV
310 320 330 340 350
LTIRVTKLFS ESSIAKVLDL VENASSKKAS TEKFITQFAR YYTPVIVFLS
360 370 380 390 400
LAVALLPPLF IPGADRADWV YRALVLLVIS CPCGLVISIP LGYFGGIGGA
410 420 430 440 450
AKHGILIKGS TFLDSLTAVK TVVFDKTGTL TKGTFKVTQV VTKNGFSESE
460 470 480 490 500
LLTLAAKAES HSTHPIALSI REAYAQSIAD SEVADYEEIA GHGIRAVVQN
510 520 530 540 550
QVVIAGNDRL LHREKIDHDT CDVAGTVVHL AVDGRYGGYI LIADEIKEDA
560 570 580 590 600
VQAIRDLKRM GVEKTVMLTG DSEIVAQSVA QQIGLDAFVA ELLPEEKVDE
610 620 630 640 650
IEQLLDPSGK AKLAFVGDGI NDAPVIARAD VGIAMGGLGS DAAIETADVV
660 670 680 690 700
LMTDAPSKVA EAIHVARKTR QIVVQNIVLA LGIKALFIAL GTIGLATLWE
710 720
AVFADVGVAL LAILNATRIA K
Length:721
Mass (Da):76,884
Last modified:November 1, 1996 - v1
Checksum:iBE187EB3900EC58B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10707.1.
PIRiS77015.

Genome annotation databases

EnsemblBacteriaiBAA10707; BAA10707; BAA10707.
KEGGisyn:slr0798.
PATRICi23843016. VBISynSp132158_3046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10707.1.
PIRiS77015.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LDINMR-A6-111[»]
2OFGNMR-X1-111[»]
2OFHNMR-X1-111[»]
ProteinModelPortaliQ59998.
SMRiQ59998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ59998. 25 interactors.

Proteomic databases

PRIDEiQ59998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10707; BAA10707; BAA10707.
KEGGisyn:slr0798.
PATRICi23843016. VBISynSp132158_3046.

Phylogenomic databases

HOGENOMiHOG000250399.
InParanoidiQ59998.
KOiK01534.
OMAiIKEDAKQ.
PhylomeDBiQ59998.

Miscellaneous databases

EvolutionaryTraceiQ59998.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
PRINTSiPR00941. CDATPASE.
SUPFAMiSSF55008. SSF55008. 1 hit.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATZN_SYNY3
AccessioniPrimary (citable) accession number: Q59998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.