Q59996 (RPSC_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable RNA polymerase sigma-C factor

Gene names

Name:	sigC
Ordered Locus Names:	sll0184

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Sequence similarities	Belongs to the sigma-70 factor family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Sigma factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, initiation Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro sigma factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Probable RNA polymerase sigma-C factor		PRO_0000093937
Regions
	DNA binding	362 – 381	20	H-T-H motif By similarity
	Motif	193 – 206	14	Polymerase core binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59996 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: CDCBE67BF031D0F9	FASTA	404	46,581
	10 20 30 40 50 60 MTKPSNDEPP LTNVRDLEAM LPLEEEDLTA DSQDLEYTAV AHRQQFSTDL VRLYLQDIGR 70 80 90 100 110 120 IPLLKRDEEV HIAQQVQSYL RLVEIQNRAA ESDAAIDQYQ TAIAVHDQLL VQLGHRPSYE 130 140 150 160 170 180 RWAKILGQTV ATLKQTLKSG KKRWAELAGL TVEELENIEK QGITAKAHMI KANLRLVVSV 190 200 210 220 230 240 AKKYQNRGLE LLDLIQEGTL GLERAVEKFD PTKGYRFSTY SYWWIRQGIT RAIATQSRMI 250 260 270 280 290 300 RLPVHITEKL NKIKRAQRKI SQEKGHTPKI DEVAEELGMT PEQVREVLTQ VPRSVSLELK 310 320 330 340 350 360 VGQDKDTELM DLLETDTQSP EDELMREALQ NDMQEILLDL TPREQEVIAL RFGFQDGVAH 370 380 390 400 SLSEIGRILN LSRERVRQIE AKALQKLRHP RRRDRIRDYY ENLG

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA10419.1.
PIR	S76573.
RefSeq	NP_442349.1. NC_000911.1. YP_005652409.1. NC_017277.1. YP_007452225.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q59996.
SMR	Q59996. Positions 145-236.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q59996. 13 interactions.
STRING	1148.sll0184.
Proteomic databases
PaxDb	Q59996.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA10419; BAA10419; BAA10419.
GeneID	12253629. 14617903. 952470.
KEGG	syn:sll0184. syy:SYNGTS_2456.
PATRIC	23842374. VBISynSp132158_2727.
Phylogenomic databases
eggNOG	COG0568.
HOGENOM	HOG000270273.
KO	K03087.
OMA	AQKVQRY.
ProtClustDB	PRK07598.
Family and domain databases
Gene3D	1.10.10.10. 2 hits.
InterPro	IPR014284. RNA_pol_sigma-70_dom. IPR000943. RNA_pol_sigma70. IPR009042. RNA_pol_sigma70_r1_2. IPR007627. RNA_pol_sigma70_r2. IPR007624. RNA_pol_sigma70_r3. IPR007630. RNA_pol_sigma70_r4. IPR013325. RNA_pol_sigma_r2. IPR013324. RNA_pol_sigma_r3_r4. IPR017848. RNA_pol_sigma_RpoD_cyanobac. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00140. Sigma70_r1_2. 1 hit. PF04542. Sigma70_r2. 1 hit. PF04539. Sigma70_r3. 1 hit. PF04545. Sigma70_r4. 1 hit. [Graphical view]
PRINTS	PR00046. SIGMA70FCT.
SUPFAM	SSF88946. Sigma_r2. 1 hit. SSF88659. Sigma_r3_r4. 2 hits.
TIGRFAMs	TIGR02997. Sig70-cyanoRpoD. 1 hit. TIGR02937. sigma70-ECF. 1 hit.
PROSITE	PS00715. SIGMA70_1. 1 hit. PS00716. SIGMA70_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPSC_SYNY3

Accession

Primary (citable) accession number: Q59996

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program