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Protein

ATP-dependent Clp protease proteolytic subunit 2

Gene

clpP2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei118 – 1181NucleophileUniRule annotation
Active sitei143 – 1431UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciSSP1148:GJOT-2952-MONOMER.
BRENDAi3.4.21.92. 382.

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit 2UniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp 2UniRule annotation
Gene namesi
Name:clpP2UniRule annotation
Ordered Locus Names:sll0534
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226ATP-dependent Clp protease proteolytic subunit 2PRO_0000179695Add
BLAST

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

IntActiQ59993. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ59993.
SMRiQ59993. Positions 23-214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000285833.
InParanoidiQ59993.
KOiK01358.
OMAiNMDRDHF.
PhylomeDBiQ59993.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
IPR018215. ClpP_Ser_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59993-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSRSPYRS PLSTLGGNNI QSVVPMVVEQ SGMGERAFDI YSRLLRERII
60 70 80 90 100
FLGTPVDDQV ADSIVAQLLF LDAEDPEKDI QLYINSPGGS VYAGLAIYDT
110 120 130 140 150
MQQIRPDVVT ICFGLAASMG AFLLSGGCKG KRMALPSSRI MIHQPLGGAQ
160 170 180 190 200
GQAVEIEIQA REILYIKDRL NTMLVEHTGQ PMEKLQEDTE RDFFMSAEEA
210 220
KEYGLIDQVI SRPNLPDPTT PVTSLG
Length:226
Mass (Da):24,823
Last modified:November 1, 1997 - v1
Checksum:iC1F3C1F4800D6AF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10867.1.
PIRiS76020.

Genome annotation databases

EnsemblBacteriaiBAA10867; BAA10867; BAA10867.
KEGGisyn:sll0534.
PATRICi23843360. VBISynSp132158_3216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10867.1.
PIRiS76020.

3D structure databases

ProteinModelPortaliQ59993.
SMRiQ59993. Positions 23-214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ59993. 4 interactions.

Protein family/group databases

MEROPSiS14.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10867; BAA10867; BAA10867.
KEGGisyn:sll0534.
PATRICi23843360. VBISynSp132158_3216.

Phylogenomic databases

HOGENOMiHOG000285833.
InParanoidiQ59993.
KOiK01358.
OMAiNMDRDHF.
PhylomeDBiQ59993.

Enzyme and pathway databases

BioCyciSSP1148:GJOT-2952-MONOMER.
BRENDAi3.4.21.92. 382.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
IPR018215. ClpP_Ser_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLPP2_SYNY3
AccessioniPrimary (citable) accession number: Q59993
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.