Q59987 (POR_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Light-dependent protochlorophyllide reductase
Short name=PCR
EC=1.3.1.33

Alternative name(s):
NADPH-protochlorophyllide oxidoreductase
Short name=LPOR
Short name=POR

Gene names

Name:	por
Synonyms:	pcr
Ordered Locus Names:	slr0506

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide).
Catalytic activity	Chlorophyllide a + NADP+ = protochlorophyllide + NADPH.
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family. POR subfamily.
Sequence caution	The sequence AAA68281.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Photosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: InterPro protochlorophyllide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Light-dependent protochlorophyllide reductase		PRO_0000219917
Experimental info
	Sequence conflict	23	1	A → R in AAA68281. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q59987 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: B805C95E139EA213	FASTA	322	36,062
	10 20 30 40 50 60 MEQPMKPTVI ITGASSGVGL YGAKALIDKG WHVIMACRNL DKTQKVADEL GFPKDSYTII 70 80 90 100 110 120 KLDLGYLDSV RRFVAQFREL GRPLKALVCN AAVYFPLLDE PLWSADDYEL SVATNHLGHF 130 140 150 160 170 180 LLCNLLLEDL KACPDADKRL IILGTVTANS KELGGKIPIP APPDLGNFEG FEAGFKKPIA 190 200 210 220 230 240 MINNKKFKSG KAYKDSKLCN MLTTRELHRR FHQETGIVFN SLYPGCVADT PLFRNHYSLF 250 260 270 280 290 300 RTIFPWFQKN VTKGYVSQEL AGERVAMVVA DDKFKDSGVH WSWGNRQQAG REAFVQELSE 310 320 QGSDAQKAQR MWDLSEKLVG LV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A prokaryotic origin for light-dependent chlorophyll biosynthesis of plants." Suzuki J.Y., Bauer C.E. Proc. Natl. Acad. Sci. U.S.A. 92:3749-3753(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.
[3]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L37783 Genomic DNA. Translation: AAA68281.1. Different initiation. BA000022 Genomic DNA. Translation: BAA10580.1.
PIR	S76636.
RefSeq	NP_442510.1. NC_000911.1. YP_005652571.1. NC_017277.1. YP_007452386.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q59987.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q59987. 4 interactions.
STRING	1148.slr0506.
Proteomic databases
PaxDb	Q59987.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA10580; BAA10580; BAA10580.
GeneID	12253883. 14618067. 952244.
KEGG	syn:slr0506. syy:SYNGTS_2618.
PATRIC	23842734. VBISynSp132158_2906.
Phylogenomic databases
eggNOG	COG1028.
KO	K00218.
OMA	SWGNRQK.
ProtClustDB	PRK07453.
Enzyme and pathway databases
BRENDA	1.3.1.33. 7369.
UniPathway	UPA00668.
Family and domain databases
Gene3D	3.40.50.720. 2 hits.
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR005979. Prochl_reduct. [Graphical view]
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH.
TIGRFAMs	TIGR01289. LPOR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

POR_SYNY3

Accession

Primary (citable) accession number: Q59987
Secondary accession number(s): Q55825

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	December 1, 2000
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program