Q59985 (IDH_STRSL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isocitrate dehydrogenase [NADP]
Short name=IDH
EC=1.1.1.42

Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase

Gene names

Name:

icd

Organism

Streptococcus salivarius

Taxonomic identifier

1304 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Biological process	Glyoxylate bypass Tricarboxylic acid cycle
Ligand	Magnesium Manganese Metal-binding NADP
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological_process	glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Isocitrate dehydrogenase [NADP]		PRO_0000083569
Sites
	Metal binding	283	1	Magnesium or manganese By similarity
	Binding site	102	1	Substrate By similarity
	Binding site	104	1	Substrate By similarity
	Binding site	108	1	Substrate By similarity
	Binding site	118	1	Substrate By similarity
	Binding site	142	1	Substrate By similarity
	Site	149	1	Critical for catalysis By similarity
	Site	219	1	Critical for catalysis By similarity
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59985 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E9860E74D470ED3B	FASTA	391	43,201
	10 20 30 40 50 60 MAEKIVMKNG QLQVSDRPII PFIEGDGVGH DIWKNAQAIF DKAVEVAYEG KRHIEWQELL 70 80 90 100 110 120 AGKKAYDKTG EWLPKETLEA IRESLVAIKG PLETPVGGGI RSLNVALRQE LDLYACVRPV 130 140 150 160 170 180 RYFDGVASPL KEPEKTNITI FRENTEDIYA GIEWEAGTAD VKRVIEFLQT EMNVNKIRFP 190 200 210 220 230 240 ESSSIGIKPI SIEGSKRLIR SAIDYALKNN LKKVTLVHKG NIQKFTEGGF RKWGYEVAQE 250 260 270 280 290 300 DYKEELLAGR LEINDIIADN FLQQILLNPE KFDVVALTNL NGDYASDALA AQVGGIGISP 310 320 330 340 350 360 GANINYQTGH AIFEATHGTA PDIADQDKAN PCSVLLSGCM LLDYIGWTEA AQLITSAIEK 370 380 390 TFKADIFTAD LAFGKQAYST SAFSNQILSI M

References

[1]	Desgagnes R., Gagnon G., Frenette M. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 25975.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L14780 Genomic DNA. Translation: AAA98355.1.
3D structure databases
ProteinModelPortal	Q59985.
SMR	Q59985. Positions 2-391.
ModBase	Search...
Proteomic databases
PRIDE	Q59985.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11835. PTHR11835. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IDH_STRSL

Accession

Primary (citable) accession number: Q59985

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	March 6, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program