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Q59985

- IDH_STRSL

UniProt

Q59985 - IDH_STRSL

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Streptococcus salivarius
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei102 – 1021SubstrateBy similarity
    Binding sitei104 – 1041SubstrateBy similarity
    Binding sitei108 – 1081SubstrateBy similarity
    Binding sitei118 – 1181SubstrateBy similarity
    Binding sitei142 – 1421SubstrateBy similarity
    Sitei149 – 1491Critical for catalysisBy similarity
    Sitei219 – 2191Critical for catalysisBy similarity
    Metal bindingi283 – 2831Magnesium or manganeseBy similarity

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
    Short name:
    IDH
    Alternative name(s):
    IDP
    NADP(+)-specific ICDH
    Oxalosuccinate decarboxylase
    Gene namesi
    Name:icd
    OrganismiStreptococcus salivarius
    Taxonomic identifieri1304 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 391391Isocitrate dehydrogenase [NADP]PRO_0000083569Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ59985.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ59985.
    SMRiQ59985. Positions 2-391.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59985-1 [UniParc]FASTAAdd to Basket

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    MAEKIVMKNG QLQVSDRPII PFIEGDGVGH DIWKNAQAIF DKAVEVAYEG    50
    KRHIEWQELL AGKKAYDKTG EWLPKETLEA IRESLVAIKG PLETPVGGGI 100
    RSLNVALRQE LDLYACVRPV RYFDGVASPL KEPEKTNITI FRENTEDIYA 150
    GIEWEAGTAD VKRVIEFLQT EMNVNKIRFP ESSSIGIKPI SIEGSKRLIR 200
    SAIDYALKNN LKKVTLVHKG NIQKFTEGGF RKWGYEVAQE DYKEELLAGR 250
    LEINDIIADN FLQQILLNPE KFDVVALTNL NGDYASDALA AQVGGIGISP 300
    GANINYQTGH AIFEATHGTA PDIADQDKAN PCSVLLSGCM LLDYIGWTEA 350
    AQLITSAIEK TFKADIFTAD LAFGKQAYST SAFSNQILSI M 391
    Length:391
    Mass (Da):43,201
    Last modified:November 1, 1996 - v1
    Checksum:iE9860E74D470ED3B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14780 Genomic DNA. Translation: AAA98355.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14780 Genomic DNA. Translation: AAA98355.1 .

    3D structure databases

    ProteinModelPortali Q59985.
    SMRi Q59985. Positions 2-391.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q59985.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Desgagnes R., Gagnon G., Frenette M.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 25975.

    Entry informationi

    Entry nameiIDH_STRSL
    AccessioniPrimary (citable) accession number: Q59985
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3