Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Streptococcus salivarius
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateBy similarity1
Binding sitei104SubstrateBy similarity1
Binding sitei108SubstrateBy similarity1
Binding sitei118SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Sitei149Critical for catalysisBy similarity1
Sitei219Critical for catalysisBy similarity1
Metal bindingi283Magnesium or manganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
OrganismiStreptococcus salivarius
Taxonomic identifieri1304 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835691 – 391Isocitrate dehydrogenase [NADP]Add BLAST391

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ59985.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi1046629.Ssal_01364.

Structurei

3D structure databases

ProteinModelPortaliQ59985.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 2 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59985-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKIVMKNG QLQVSDRPII PFIEGDGVGH DIWKNAQAIF DKAVEVAYEG
60 70 80 90 100
KRHIEWQELL AGKKAYDKTG EWLPKETLEA IRESLVAIKG PLETPVGGGI
110 120 130 140 150
RSLNVALRQE LDLYACVRPV RYFDGVASPL KEPEKTNITI FRENTEDIYA
160 170 180 190 200
GIEWEAGTAD VKRVIEFLQT EMNVNKIRFP ESSSIGIKPI SIEGSKRLIR
210 220 230 240 250
SAIDYALKNN LKKVTLVHKG NIQKFTEGGF RKWGYEVAQE DYKEELLAGR
260 270 280 290 300
LEINDIIADN FLQQILLNPE KFDVVALTNL NGDYASDALA AQVGGIGISP
310 320 330 340 350
GANINYQTGH AIFEATHGTA PDIADQDKAN PCSVLLSGCM LLDYIGWTEA
360 370 380 390
AQLITSAIEK TFKADIFTAD LAFGKQAYST SAFSNQILSI M
Length:391
Mass (Da):43,201
Last modified:November 1, 1996 - v1
Checksum:iE9860E74D470ED3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14780 Genomic DNA. Translation: AAA98355.1.
RefSeqiWP_045768878.1. NZ_JYOY01000014.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14780 Genomic DNA. Translation: AAA98355.1.
RefSeqiWP_045768878.1. NZ_JYOY01000014.1.

3D structure databases

ProteinModelPortaliQ59985.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1046629.Ssal_01364.

Proteomic databases

PRIDEiQ59985.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 2 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDH_STRSL
AccessioniPrimary (citable) accession number: Q59985
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.