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Q59985 (IDH_STRSL) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]

Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icd
OrganismStreptococcus salivarius
Taxonomic identifier1304 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Isocitrate dehydrogenase [NADP]
PRO_0000083569

Sites

Metal binding2831Magnesium or manganese By similarity
Binding site1021Substrate By similarity
Binding site1041Substrate By similarity
Binding site1081Substrate By similarity
Binding site1181Substrate By similarity
Binding site1421Substrate By similarity
Site1491Critical for catalysis By similarity
Site2191Critical for catalysis By similarity

Amino acid modifications

Modified residue1021Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59985 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E9860E74D470ED3B

FASTA39143,201
        10         20         30         40         50         60 
MAEKIVMKNG QLQVSDRPII PFIEGDGVGH DIWKNAQAIF DKAVEVAYEG KRHIEWQELL 

        70         80         90        100        110        120 
AGKKAYDKTG EWLPKETLEA IRESLVAIKG PLETPVGGGI RSLNVALRQE LDLYACVRPV 

       130        140        150        160        170        180 
RYFDGVASPL KEPEKTNITI FRENTEDIYA GIEWEAGTAD VKRVIEFLQT EMNVNKIRFP 

       190        200        210        220        230        240 
ESSSIGIKPI SIEGSKRLIR SAIDYALKNN LKKVTLVHKG NIQKFTEGGF RKWGYEVAQE 

       250        260        270        280        290        300 
DYKEELLAGR LEINDIIADN FLQQILLNPE KFDVVALTNL NGDYASDALA AQVGGIGISP 

       310        320        330        340        350        360 
GANINYQTGH AIFEATHGTA PDIADQDKAN PCSVLLSGCM LLDYIGWTEA AQLITSAIEK 

       370        380        390 
TFKADIFTAD LAFGKQAYST SAFSNQILSI M 

« Hide

References

[1]Desgagnes R., Gagnon G., Frenette M.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 25975.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L14780 Genomic DNA. Translation: AAA98355.1.

3D structure databases

ProteinModelPortalQ59985.
SMRQ59985. Positions 2-391.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ59985.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_STRSL
AccessionPrimary (citable) accession number: Q59985
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families