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Q59985

- IDH_STRSL

UniProt

Q59985 - IDH_STRSL

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Streptococcus salivarius
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021SubstrateBy similarity
Binding sitei104 – 1041SubstrateBy similarity
Binding sitei108 – 1081SubstrateBy similarity
Binding sitei118 – 1181SubstrateBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Sitei149 – 1491Critical for catalysisBy similarity
Sitei219 – 2191Critical for catalysisBy similarity
Metal bindingi283 – 2831Magnesium or manganeseBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
OrganismiStreptococcus salivarius
Taxonomic identifieri1304 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 391391Isocitrate dehydrogenase [NADP]PRO_0000083569Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ59985.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59985.
SMRiQ59985. Positions 2-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59985-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEKIVMKNG QLQVSDRPII PFIEGDGVGH DIWKNAQAIF DKAVEVAYEG
60 70 80 90 100
KRHIEWQELL AGKKAYDKTG EWLPKETLEA IRESLVAIKG PLETPVGGGI
110 120 130 140 150
RSLNVALRQE LDLYACVRPV RYFDGVASPL KEPEKTNITI FRENTEDIYA
160 170 180 190 200
GIEWEAGTAD VKRVIEFLQT EMNVNKIRFP ESSSIGIKPI SIEGSKRLIR
210 220 230 240 250
SAIDYALKNN LKKVTLVHKG NIQKFTEGGF RKWGYEVAQE DYKEELLAGR
260 270 280 290 300
LEINDIIADN FLQQILLNPE KFDVVALTNL NGDYASDALA AQVGGIGISP
310 320 330 340 350
GANINYQTGH AIFEATHGTA PDIADQDKAN PCSVLLSGCM LLDYIGWTEA
360 370 380 390
AQLITSAIEK TFKADIFTAD LAFGKQAYST SAFSNQILSI M
Length:391
Mass (Da):43,201
Last modified:November 1, 1996 - v1
Checksum:iE9860E74D470ED3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14780 Genomic DNA. Translation: AAA98355.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14780 Genomic DNA. Translation: AAA98355.1 .

3D structure databases

ProteinModelPortali Q59985.
SMRi Q59985. Positions 2-391.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q59985.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Desgagnes R., Gagnon G., Frenette M.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 25975.

Entry informationi

Entry nameiIDH_STRSL
AccessioniPrimary (citable) accession number: Q59985
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3