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Protein

DNA gyrase subunit B

Gene

gyrB

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation, Ca2+UniRule annotationNote: Binds two Mg2+ per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn2+ or Ca2+.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi433 – 4331Magnesium 1; catalyticUniRule annotation
Metal bindingi506 – 5061Magnesium 1; catalyticUniRule annotation
Metal bindingi506 – 5061Magnesium 2UniRule annotation
Metal bindingi508 – 5081Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, DNA-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA gyrase subunit BUniRule annotationSAAS annotation (EC:5.99.1.3UniRule annotationSAAS annotation)
Gene namesi
Name:gyrBUniRule annotationImported
Synonyms:gyrB_1Imported, gyrB_2Imported, gyrB_3Imported
ORF Names:ERS003574_00417Imported, ERS019416_01766Imported, ERS019473_01969Imported, ERS019595_01309Imported, ERS020136_01398Imported, ERS020140_01740Imported, ERS020148_00638Imported, ERS020157_01626Imported, ERS020491_02088Imported, ERS020535_01750Imported, ERS020697_01202Imported, ERS021057_00935Imported, ERS021300_00002Imported, ERS021368_02050Imported, ERS021447_06941Imported, ERS021634_06258Imported, ERS022045_05472Imported, ERS022199_01981Imported, ERS022232_05511Imported, ERS050646_01103Imported, ERS070077_00914Imported, ERS232442_02046Imported, ERS232471_00791Imported, ERS232499_02012Imported, ERS232512_02226Imported, ERS367628_01627Imported, ERS367764_01987Imported, ERS408871_02096Imported, ERS408893_01936Imported, ERS409105_01549Imported, ERS409444_00222Imported, ERS409576_01989Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000043214 Componenti: Unassembled WGS sequence
  • UP000046964 Componenti: Unassembled WGS sequence
  • UP000072705 Componenti: Unassembled WGS sequence
  • UP000071406 Componenti: Unassembled WGS sequence
  • UP000044715 Componenti: Unassembled WGS sequence
  • UP000041568 Componenti: Unassembled WGS sequence
  • UP000044228 Componenti: Unassembled WGS sequence
  • UP000043857 Componenti: Unassembled WGS sequence
  • UP000075018 Componenti: Unassembled WGS sequence
  • UP000048265 Componenti: Unassembled WGS sequence
  • UP000075122 Componenti: Unassembled WGS sequence
  • UP000044638 Componenti: Unassembled WGS sequence
  • UP000046356 Componenti: Unassembled WGS sequence
  • UP000046081 Componenti: Unassembled WGS sequence
  • UP000046175 Componenti: Unassembled WGS sequence
  • UP000074651 Componenti: Unassembled WGS sequence
  • UP000071581 Componenti: Unassembled WGS sequence
  • UP000069711 Componenti: Unassembled WGS sequence
  • UP000042523 Componenti: Unassembled WGS sequence
  • UP000045409 Componenti: Unassembled WGS sequence
  • UP000043523 Componenti: Unassembled WGS sequence
  • UP000047188 Componenti: Unassembled WGS sequence
  • UP000070772 Componenti: Unassembled WGS sequence
  • UP000039362 Componenti: Unassembled WGS sequence
  • UP000043492 Componenti: Unassembled WGS sequence
  • UP000074925 Componenti: Unassembled WGS sequence
  • UP000043644 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei458 – 4581Interaction with DNAUniRule annotation
Sitei461 – 4611Interaction with DNAUniRule annotation

Protein-protein interaction databases

STRINGi171101.spr0715.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini427 – 541115ToprimInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type II topoisomerase family.UniRule annotation
Contains 1 Toprim domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C7D. Bacteria.
COG0187. LUCA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
HAMAPiMF_01898. GyrB.
InterProiIPR002288. DNA_gyrase_B_C.
IPR011557. GyrB.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01059. gyrB. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEEIKNLQA QDYDASQIQV LEGLEAVRMR PGMYIGSTSK EGLHHLVWEI
60 70 80 90 100
VDNSIDEALA GFASHIQVFI EPDDSITVVD DGRGIPVDIQ EKTGRPAVET
110 120 130 140 150
VFTVLHAGGK FGGGGYKVSG GLHGVGSSVV NALSTQLDVH VHKNGKIHYQ
160 170 180 190 200
EYRRGHVVAD LEVVGDTDRT GTTVHFTPDP EIFTETTIFD FDKLNKRIQE
210 220 230 240 250
LAFLNRGLQI SITDKRQGLE QTKHYHYEGG IASYVEYINE NKDVIFDTPI
260 270 280 290 300
YTDGEMDDIT VEVAMQYTTG YHENVMSFAN NIHTHEGGTH EQGFRTALTR
310 320 330 340 350
VINDYARKNK LLKDNEDNLT GEDVREGLTA VISVKHPNPQ FEGQTKTKLG
360 370 380 390 400
NSEVVKITNR LFSEAFSDFL MENPQIAKRI VEKGILAAKA RVAAKRAREV
410 420 430 440 450
TRKKSGLEIS NLPGKLADCS SNNPAETELF IVEGDSAGGS AKSGRNREFQ
460 470 480 490 500
AILPIRGKIL NVEKASMDKI LANEEIRSLF TAMGTGFGAE FDVSKARYQK
510 520 530 540 550
LVLMTDADVD GAHIRTLLLT LIYRYMKPIL EAGYVYIAQP PIYGVKVGSE
560 570 580 590 600
IKEYIQPGAD QEIKLQEALA RYSEGRTKPT IQRYKGLGEM DDHQLWETTM
610 620 630 640
DPEHRLMARV SVDDAAEADK IFDMLMGDRV EPRREFIEEN AVYSTLDV
Length:648
Mass (Da):72,252
Last modified:November 1, 1996 - v1
Checksum:i65DB9BA2948933F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ175189 Genomic DNA. Translation: AAZ92990.1.
DQ175198 Genomic DNA. Translation: AAZ92999.1.
DQ175205 Genomic DNA. Translation: AAZ93006.1.
DQ175211 Genomic DNA. Translation: AAZ93012.1.
DQ175216 Genomic DNA. Translation: AAZ93017.1.
DQ175217 Genomic DNA. Translation: AAZ93018.1.
DQ175218 Genomic DNA. Translation: AAZ93019.1.
DQ175219 Genomic DNA. Translation: AAZ93020.1.
DQ175220 Genomic DNA. Translation: AAZ93021.1.
DQ175221 Genomic DNA. Translation: AAZ93022.1.
DQ175222 Genomic DNA. Translation: AAZ93023.1.
DQ175223 Genomic DNA. Translation: AAZ93024.1.
DQ175224 Genomic DNA. Translation: AAZ93025.1.
DQ175225 Genomic DNA. Translation: AAZ93026.1.
DQ175227 Genomic DNA. Translation: AAZ93028.1.
DQ175230 Genomic DNA. Translation: AAZ93031.1.
DQ175232 Genomic DNA. Translation: AAZ93033.1.
DQ175233 Genomic DNA. Translation: AAZ93034.1.
DQ175234 Genomic DNA. Translation: AAZ93035.1.
DQ175236 Genomic DNA. Translation: AAZ93037.1.
DQ175237 Genomic DNA. Translation: AAZ93038.1.
DQ175238 Genomic DNA. Translation: AAZ93039.1.
DQ175242 Genomic DNA. Translation: AAZ93043.1.
Z67740 Genomic DNA. Translation: CAA91553.1.
CFBA01000009 Genomic DNA. Translation: CEV47067.1.
CFGX01000042 Genomic DNA. Translation: CEY69335.1.
CIMA01000037 Genomic DNA. Translation: CGF04132.1.
CHOW01000038 Genomic DNA. Translation: CGF84100.1.
CKJB01000009 Genomic DNA. Translation: CIT95303.1.
CKOI01000026 Genomic DNA. Translation: CIX15593.1.
CKVN01000072 Genomic DNA. Translation: CJD01833.1.
CLBL01000001 Genomic DNA. Translation: CJF15045.1.
CLFU01000080 Genomic DNA. Translation: CJJ98829.1.
CLJU01000083 Genomic DNA. Translation: CJM24679.1.
CLMB01000057 Genomic DNA. Translation: CJM85438.1.
CLNH01000027 Genomic DNA. Translation: CJO19086.1.
CMNT01000042 Genomic DNA. Translation: CKD73455.1.
CMOR01000008 Genomic DNA. Translation: CKE01452.1.
CMQD01000051 Genomic DNA. Translation: CKF18426.1.
CMQE01000040 Genomic DNA. Translation: CKF18879.1.
CQYS01000007 Genomic DNA. Translation: COB86610.1.
CQYP01000020 Genomic DNA. Translation: COC09339.1.
CQZC01000021 Genomic DNA. Translation: COC42686.1.
CRCG01000041 Genomic DNA. Translation: COE69370.1.
CROR01000011 Genomic DNA. Translation: COM90068.1.
CRQU01000014 Genomic DNA. Translation: COO62894.1.
CHXG02000064 Genomic DNA. Translation: CTH56993.1.
FCTV01000016 Genomic DNA. Translation: CVM88084.1.
FCWP01000013 Genomic DNA. Translation: CVO96498.1.
FCXK01000020 Genomic DNA. Translation: CVP43346.1.
FDGM01000007 Genomic DNA. Translation: CVU02021.1.
FEFC01000020 Genomic DNA. Translation: CWH24395.1.
FEIL01000001 Genomic DNA. Translation: CWI35097.1.
FENL01000015 Genomic DNA. Translation: CWL70329.1.
FIXX01000002 Genomic DNA. Translation: CZD66863.1.
FIYI01000011 Genomic DNA. Translation: CZD98934.1.
RefSeqiWP_000134047.1. NZ_LSSU01000154.1.

Genome annotation databases

EnsemblBacteriaiCEO68596; CEO68596; ERS019717_00238.
CEO69111; CEO69111; ERS019716_01612.
CRE62560; CRE62560; ERS019239_01536.
CRF36021; CRF36021; ERS020326_01905.
CRG74156; CRG74156; ERS069013_00976.
CTF72710; CTF72710; ERS044044_02664.
CTF75703; CTF75703; ERS044089_02421.
CTF78983; CTF78983; ERS069987_02476.
CTF79284; CTF79284; ERS044084_02423.
CTF79933; CTF79933; ERS044142_02337.
CTF89019; CTF89019; ERS070095_02345.
CTF90817; CTF90817; ERS070047_02436.
CTF93832; CTF93832; ERS044073_02182.
CTF95439; CTF95439; ERS043971_02580.
CTF96442; CTF96442; ERS070209_02307.
CTF97931; CTF97931; ERS043910_01960.
CTF99209; CTF99209; ERS043901_02162.
CTF99508; CTF99508; ERS043951_02297.
CTF99627; CTF99627; ERS070139_02380.
CTG00245; CTG00245; ERS043838_02387.
CTG04910; CTG04910; ERS043833_01939.
CTG08504; CTG08504; ERS070198_02199.
CTG09965; CTG09965; ERS070151_02412.
CTG10634; CTG10634; ERS043992_02314.
CTG21476; CTG21476; ERS043909_02482.
CTG22573; CTG22573; ERS043994_01873.
CTG37039; CTG37039; ERS070177_00708.
CTG40056; CTG40056; ERS070185_00708.
CTG40892; CTG40892; ERS070048_02617.
CTG41624; CTG41624; ERS070008_02492.
CTG42989; CTG42989; ERS069933_02298.
CTG43672; CTG43672; ERS070210_00700.
CTG46885; CTG46885; ERS043867_02121.
CTG47550; CTG47550; ERS043937_02608.
CTG48768; CTG48768; ERS070179_00689.
CTG55038; CTG55038; ERS070126_02603.
CTG56295; CTG56295; ERS070199_02612.
CTG59644; CTG59644; ERS070104_02469.
CTG63093; CTG63093; ERS069934_02004.
CTG63368; CTG63368; ERS043944_00804.
CTG68773; CTG68773; ERS070067_02614.
CTG91185; CTG91185; ERS070188_00680.
CTG91526; CTG91526; ERS070118_02592.
CTG91822; CTG91822; ERS044104_00715.
CTG92168; CTG92168; ERS044085_00676.
CTG92792; CTG92792; ERS070063_00668.
CTG96646; CTG96646; ERS044092_00686.
CTG97047; CTG97047; ERS043991_00710.
CTG98616; CTG98616; ERS044168_00703.
CTH02896; CTH02896; ERS043999_00708.
CTH10243; CTH10243; ERS044014_02218.
CTH15627; CTH15627; ERS044166_00741.
CTH17935; CTH17935; ERS070059_00811.
CTH33609; CTH33609; ERS044067_00961.
CTH35785; CTH35785; ERS044080_00989.
CTH38194; CTH38194; ERS044135_00960.
CTH40625; CTH40625; ERS044139_00424.
CTH45891; CTH45891; ERS069972_00833.
CTH48446; CTH48446; ERS044169_00916.
CTH50092; CTH50092; ERS070020_00984.
CTH50354; CTH50354; ERS069923_01019.
CTH54519; CTH54519; ERS070158_00945.
CTH56993; CTH56993; ERS070077_00914.
CTH59066; CTH59066; ERS070081_00858.
CTH61224; CTH61224; ERS069982_00922.
CTH61835; CTH61835; ERS043835_00990.
CTH62055; CTH62055; ERS069937_00943.
CTH62571; CTH62571; ERS070204_01005.
CTH62603; CTH62603; ERS070066_01029.
CTH62904; CTH62904; ERS070012_00936.
CTH69539; CTH69539; ERS044134_00863.
CTH70710; CTH70710; ERS043952_00993.
CTH72055; CTH72055; ERS070040_01018.
CTH72636; CTH72636; ERS043851_00993.
CTH75722; CTH75722; ERS070016_00938.
CTH84306; CTH84306; ERS044172_00895.
CTH85233; CTH85233; ERS069924_00905.
CTH87637; CTH87637; ERS043852_00902.
CTH89576; CTH89576; ERS043993_01039.
CTH91436; CTH91436; ERS044011_00742.
CTH94934; CTH94934; ERS043958_00921.
CTH97438; CTH97438; ERS044010_00981.
CTH99821; CTH99821; ERS070120_00487.
CTI00210; CTI00210; ERS043948_00926.
CTI02671; CTI02671; ERS043959_00907.
CTI04527; CTI04527; ERS043832_00993.
CTI05453; CTI05453; ERS043855_01012.
CTI07090; CTI07090; ERS070098_00625.
CTI07580; CTI07580; ERS043883_00985.
CTI08935; CTI08935; ERS043980_00916.
CTI11026; CTI11026; ERS070142_00911.
CTI14120; CTI14120; ERS070116_00907.
CTI15350; CTI15350; ERS070111_00815.
CTI24717; CTI24717; ERS069925_00900.
CTI35624; CTI35624; ERS070154_00895.
CTI44415; CTI44415; ERS043964_00868.
CTI70413; CTI70413; ERS070074_00823.
CTJ00735; CTJ00735; ERS043869_00931.
CTJ08896; CTJ08896; ERS070171_00898.
CTJ11382; CTJ11382; ERS043925_00916.
CTJ21268; CTJ21268; ERS070172_00877.
CTJ26595; CTJ26595; ERS043881_00867.
CTJ29978; CTJ29978; ERS069973_02257.
CTJ44280; CTJ44280; ERS044064_01533.
CTN21827; CTN21827; ERS070026_00938.
CTN22294; CTN22294; ERS069948_01003.
CTN25883; CTN25883; ERS070202_01000.
CTN29617; CTN29617; ERS043854_00857.
CTN64126; CTN64126; ERS044126_00904.
CTN65413; CTN65413; ERS070135_00779.
CTN87067; CTN87067; ERS070143_01714.
CTO26305; CTO26305; ERS069975_00882.
CTO27803; CTO27803; ERS043988_00873.
CTO51384; CTO51384; ERS070148_02328.
CTO56282; CTO56282; ERS069986_00839.
CTO56662; CTO56662; ERS043928_00959.
CTO58062; CTO58062; ERS069985_00929.
CTO58140; CTO58140; ERS070076_02018.
CTO61081; CTO61081; ERS043858_00911.
CTO70121; CTO70121; ERS070097_00934.
CTO73624; CTO73624; ERS044091_00910.
CTO85459; CTO85459; ERS044048_00972.
CTO95004; CTO95004; ERS043978_01741.
CTO98151; CTO98151; ERS044103_00914.
CTO98178; CTO98178; ERS044127_00917.
CTP05488; CTP05488; ERS044146_00944.
CTP29716; CTP29716; ERS070078_00828.
CTP31611; CTP31611; ERS043847_00913.
CTP37218; CTP37218; ERS070117_00804.
CTP37975; CTP37975; ERS070053_01030.
CTP38837; CTP38837; ERS044155_00930.
CTP46826; CTP46826; ERS044075_00721.
CTP62706; CTP62706; ERS069938_00861.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ175189 Genomic DNA. Translation: AAZ92990.1.
DQ175198 Genomic DNA. Translation: AAZ92999.1.
DQ175205 Genomic DNA. Translation: AAZ93006.1.
DQ175211 Genomic DNA. Translation: AAZ93012.1.
DQ175216 Genomic DNA. Translation: AAZ93017.1.
DQ175217 Genomic DNA. Translation: AAZ93018.1.
DQ175218 Genomic DNA. Translation: AAZ93019.1.
DQ175219 Genomic DNA. Translation: AAZ93020.1.
DQ175220 Genomic DNA. Translation: AAZ93021.1.
DQ175221 Genomic DNA. Translation: AAZ93022.1.
DQ175222 Genomic DNA. Translation: AAZ93023.1.
DQ175223 Genomic DNA. Translation: AAZ93024.1.
DQ175224 Genomic DNA. Translation: AAZ93025.1.
DQ175225 Genomic DNA. Translation: AAZ93026.1.
DQ175227 Genomic DNA. Translation: AAZ93028.1.
DQ175230 Genomic DNA. Translation: AAZ93031.1.
DQ175232 Genomic DNA. Translation: AAZ93033.1.
DQ175233 Genomic DNA. Translation: AAZ93034.1.
DQ175234 Genomic DNA. Translation: AAZ93035.1.
DQ175236 Genomic DNA. Translation: AAZ93037.1.
DQ175237 Genomic DNA. Translation: AAZ93038.1.
DQ175238 Genomic DNA. Translation: AAZ93039.1.
DQ175242 Genomic DNA. Translation: AAZ93043.1.
Z67740 Genomic DNA. Translation: CAA91553.1.
CFBA01000009 Genomic DNA. Translation: CEV47067.1.
CFGX01000042 Genomic DNA. Translation: CEY69335.1.
CIMA01000037 Genomic DNA. Translation: CGF04132.1.
CHOW01000038 Genomic DNA. Translation: CGF84100.1.
CKJB01000009 Genomic DNA. Translation: CIT95303.1.
CKOI01000026 Genomic DNA. Translation: CIX15593.1.
CKVN01000072 Genomic DNA. Translation: CJD01833.1.
CLBL01000001 Genomic DNA. Translation: CJF15045.1.
CLFU01000080 Genomic DNA. Translation: CJJ98829.1.
CLJU01000083 Genomic DNA. Translation: CJM24679.1.
CLMB01000057 Genomic DNA. Translation: CJM85438.1.
CLNH01000027 Genomic DNA. Translation: CJO19086.1.
CMNT01000042 Genomic DNA. Translation: CKD73455.1.
CMOR01000008 Genomic DNA. Translation: CKE01452.1.
CMQD01000051 Genomic DNA. Translation: CKF18426.1.
CMQE01000040 Genomic DNA. Translation: CKF18879.1.
CQYS01000007 Genomic DNA. Translation: COB86610.1.
CQYP01000020 Genomic DNA. Translation: COC09339.1.
CQZC01000021 Genomic DNA. Translation: COC42686.1.
CRCG01000041 Genomic DNA. Translation: COE69370.1.
CROR01000011 Genomic DNA. Translation: COM90068.1.
CRQU01000014 Genomic DNA. Translation: COO62894.1.
CHXG02000064 Genomic DNA. Translation: CTH56993.1.
FCTV01000016 Genomic DNA. Translation: CVM88084.1.
FCWP01000013 Genomic DNA. Translation: CVO96498.1.
FCXK01000020 Genomic DNA. Translation: CVP43346.1.
FDGM01000007 Genomic DNA. Translation: CVU02021.1.
FEFC01000020 Genomic DNA. Translation: CWH24395.1.
FEIL01000001 Genomic DNA. Translation: CWI35097.1.
FENL01000015 Genomic DNA. Translation: CWL70329.1.
FIXX01000002 Genomic DNA. Translation: CZD66863.1.
FIYI01000011 Genomic DNA. Translation: CZD98934.1.
RefSeqiWP_000134047.1. NZ_LSSU01000154.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr0715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCEO68596; CEO68596; ERS019717_00238.
CEO69111; CEO69111; ERS019716_01612.
CRE62560; CRE62560; ERS019239_01536.
CRF36021; CRF36021; ERS020326_01905.
CRG74156; CRG74156; ERS069013_00976.
CTF72710; CTF72710; ERS044044_02664.
CTF75703; CTF75703; ERS044089_02421.
CTF78983; CTF78983; ERS069987_02476.
CTF79284; CTF79284; ERS044084_02423.
CTF79933; CTF79933; ERS044142_02337.
CTF89019; CTF89019; ERS070095_02345.
CTF90817; CTF90817; ERS070047_02436.
CTF93832; CTF93832; ERS044073_02182.
CTF95439; CTF95439; ERS043971_02580.
CTF96442; CTF96442; ERS070209_02307.
CTF97931; CTF97931; ERS043910_01960.
CTF99209; CTF99209; ERS043901_02162.
CTF99508; CTF99508; ERS043951_02297.
CTF99627; CTF99627; ERS070139_02380.
CTG00245; CTG00245; ERS043838_02387.
CTG04910; CTG04910; ERS043833_01939.
CTG08504; CTG08504; ERS070198_02199.
CTG09965; CTG09965; ERS070151_02412.
CTG10634; CTG10634; ERS043992_02314.
CTG21476; CTG21476; ERS043909_02482.
CTG22573; CTG22573; ERS043994_01873.
CTG37039; CTG37039; ERS070177_00708.
CTG40056; CTG40056; ERS070185_00708.
CTG40892; CTG40892; ERS070048_02617.
CTG41624; CTG41624; ERS070008_02492.
CTG42989; CTG42989; ERS069933_02298.
CTG43672; CTG43672; ERS070210_00700.
CTG46885; CTG46885; ERS043867_02121.
CTG47550; CTG47550; ERS043937_02608.
CTG48768; CTG48768; ERS070179_00689.
CTG55038; CTG55038; ERS070126_02603.
CTG56295; CTG56295; ERS070199_02612.
CTG59644; CTG59644; ERS070104_02469.
CTG63093; CTG63093; ERS069934_02004.
CTG63368; CTG63368; ERS043944_00804.
CTG68773; CTG68773; ERS070067_02614.
CTG91185; CTG91185; ERS070188_00680.
CTG91526; CTG91526; ERS070118_02592.
CTG91822; CTG91822; ERS044104_00715.
CTG92168; CTG92168; ERS044085_00676.
CTG92792; CTG92792; ERS070063_00668.
CTG96646; CTG96646; ERS044092_00686.
CTG97047; CTG97047; ERS043991_00710.
CTG98616; CTG98616; ERS044168_00703.
CTH02896; CTH02896; ERS043999_00708.
CTH10243; CTH10243; ERS044014_02218.
CTH15627; CTH15627; ERS044166_00741.
CTH17935; CTH17935; ERS070059_00811.
CTH33609; CTH33609; ERS044067_00961.
CTH35785; CTH35785; ERS044080_00989.
CTH38194; CTH38194; ERS044135_00960.
CTH40625; CTH40625; ERS044139_00424.
CTH45891; CTH45891; ERS069972_00833.
CTH48446; CTH48446; ERS044169_00916.
CTH50092; CTH50092; ERS070020_00984.
CTH50354; CTH50354; ERS069923_01019.
CTH54519; CTH54519; ERS070158_00945.
CTH56993; CTH56993; ERS070077_00914.
CTH59066; CTH59066; ERS070081_00858.
CTH61224; CTH61224; ERS069982_00922.
CTH61835; CTH61835; ERS043835_00990.
CTH62055; CTH62055; ERS069937_00943.
CTH62571; CTH62571; ERS070204_01005.
CTH62603; CTH62603; ERS070066_01029.
CTH62904; CTH62904; ERS070012_00936.
CTH69539; CTH69539; ERS044134_00863.
CTH70710; CTH70710; ERS043952_00993.
CTH72055; CTH72055; ERS070040_01018.
CTH72636; CTH72636; ERS043851_00993.
CTH75722; CTH75722; ERS070016_00938.
CTH84306; CTH84306; ERS044172_00895.
CTH85233; CTH85233; ERS069924_00905.
CTH87637; CTH87637; ERS043852_00902.
CTH89576; CTH89576; ERS043993_01039.
CTH91436; CTH91436; ERS044011_00742.
CTH94934; CTH94934; ERS043958_00921.
CTH97438; CTH97438; ERS044010_00981.
CTH99821; CTH99821; ERS070120_00487.
CTI00210; CTI00210; ERS043948_00926.
CTI02671; CTI02671; ERS043959_00907.
CTI04527; CTI04527; ERS043832_00993.
CTI05453; CTI05453; ERS043855_01012.
CTI07090; CTI07090; ERS070098_00625.
CTI07580; CTI07580; ERS043883_00985.
CTI08935; CTI08935; ERS043980_00916.
CTI11026; CTI11026; ERS070142_00911.
CTI14120; CTI14120; ERS070116_00907.
CTI15350; CTI15350; ERS070111_00815.
CTI24717; CTI24717; ERS069925_00900.
CTI35624; CTI35624; ERS070154_00895.
CTI44415; CTI44415; ERS043964_00868.
CTI70413; CTI70413; ERS070074_00823.
CTJ00735; CTJ00735; ERS043869_00931.
CTJ08896; CTJ08896; ERS070171_00898.
CTJ11382; CTJ11382; ERS043925_00916.
CTJ21268; CTJ21268; ERS070172_00877.
CTJ26595; CTJ26595; ERS043881_00867.
CTJ29978; CTJ29978; ERS069973_02257.
CTJ44280; CTJ44280; ERS044064_01533.
CTN21827; CTN21827; ERS070026_00938.
CTN22294; CTN22294; ERS069948_01003.
CTN25883; CTN25883; ERS070202_01000.
CTN29617; CTN29617; ERS043854_00857.
CTN64126; CTN64126; ERS044126_00904.
CTN65413; CTN65413; ERS070135_00779.
CTN87067; CTN87067; ERS070143_01714.
CTO26305; CTO26305; ERS069975_00882.
CTO27803; CTO27803; ERS043988_00873.
CTO51384; CTO51384; ERS070148_02328.
CTO56282; CTO56282; ERS069986_00839.
CTO56662; CTO56662; ERS043928_00959.
CTO58062; CTO58062; ERS069985_00929.
CTO58140; CTO58140; ERS070076_02018.
CTO61081; CTO61081; ERS043858_00911.
CTO70121; CTO70121; ERS070097_00934.
CTO73624; CTO73624; ERS044091_00910.
CTO85459; CTO85459; ERS044048_00972.
CTO95004; CTO95004; ERS043978_01741.
CTO98151; CTO98151; ERS044103_00914.
CTO98178; CTO98178; ERS044127_00917.
CTP05488; CTP05488; ERS044146_00944.
CTP29716; CTP29716; ERS070078_00828.
CTP31611; CTP31611; ERS043847_00913.
CTP37218; CTP37218; ERS070117_00804.
CTP37975; CTP37975; ERS070053_01030.
CTP38837; CTP38837; ERS044155_00930.
CTP46826; CTP46826; ERS044075_00721.
CTP62706; CTP62706; ERS069938_00861.

Phylogenomic databases

eggNOGiENOG4105C7D. Bacteria.
COG0187. LUCA.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
HAMAPiMF_01898. GyrB.
InterProiIPR002288. DNA_gyrase_B_C.
IPR011557. GyrB.
IPR003594. HATPase_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01059. gyrB. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Ser-127-to-Leu substitution in the DNA gyrase B subunit of Streptococcus pneumoniae is implicated in novobiocin resistance."
    Munoz R., Bustamante M., de la Campa A.G.
    J. Bacteriol. 177:4166-4170(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Clinical isolateImported.
  2. "Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance."
    Pan X., Fisher M.
    J. Bacteriol. 178:4060-4069(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Clinical isolateImported.
  3. "Molecular evolution perspectives on intraspecific lateral DNA transfer of topoisomerase and gyrase loci in Streptococcus pneumoniae, with implications for fluoroquinolone resistance development and spread."
    Stanhope M.J., Walsh S.L., Becker J.A., Italia M.J., Ingraham K.A., Gwynn M.N., Mathie T., Poupard J.A., Miller L.A., Brown J.R., Amrine-Madsen H.
    Antimicrob. Agents Chemother. 49:4315-4326(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 0.19IS99SImported, 0.74Oh94SImported, 292.1AT96SImported, 432.1JA00SImported, 544.1Tx99SImported, 581.1Ny99SImported, 582.1CH00SImported, 584.1Ca99SImported, 586.1CH99SImported, 588.1JA99SImported, 636.1Ca99SImported, 638.2CH99SImported, 638.3CH99SImported, 67.1FR92SImported, 672.1US00SImported, 68.1SW99SImported, 687.1CH99SImported, 700.1CH00SImported, 71.1SW99SImported, 720.1CH00SImported, 720.3CH00SImported, 720.4CH00SImported and 95.1In00SImported.
  4. Murphy D.
    Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 6AImported, 6BImported, SMRU1025Imported, SMRU1187Imported, SMRU1547Imported, SMRU1790Imported, SMRU1858Imported, SMRU1937Imported, SMRU2535Imported, SMRU258Imported, SMRU2689Imported, SMRU2722Imported, SMRU315Imported, SMRU437Imported, SMRU626Imported, SMRU630Imported, SMRU638Imported, SMRU647Imported, SMRU981Imported, Type strain: NImported and type strain: NImported.
  5. Informatics Pathogen
    Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MD5110Imported.
  6. Pathogen Informatics
    Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2842STDY5644190Imported, 2842STDY5644328Imported, 2842STDY5753086Imported, 2842STDY5753108Imported, 2842STDY5753322Imported, 2842STDY5753665Imported, 2842STDY5753798Imported, B15467Imported and D55377Imported.

Entry informationi

Entry nameiQ59957_STREE
AccessioniPrimary (citable) accession number: Q59957
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.