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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021SubstrateBy similarity
Binding sitei104 – 1041SubstrateBy similarity
Binding sitei108 – 1081SubstrateBy similarity
Binding sitei118 – 1181SubstrateBy similarity
Binding sitei142 – 1421SubstrateBy similarity
Sitei149 – 1491Critical for catalysisBy similarity
Sitei219 – 2191Critical for catalysisBy similarity
Metal bindingi283 – 2831Magnesium or manganeseBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Synonyms:idh
Ordered Locus Names:SMU_672
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Isocitrate dehydrogenase [NADP]PRO_0000083568Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ59940.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi210007.SMU.672.

Structurei

3D structure databases

ProteinModelPortaliQ59940.
SMRiQ59940. Positions 2-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OMAiKGQNTAN.
OrthoDBiEOG6SNDTP.
PhylomeDBiQ59940.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKVSFEEG KLQVPDKPVI PYIEGDGVGQ DIWKNAQIVF DKAIAKVYGG
60 70 80 90 100
HKQVIWREVL AGKKAYNETG NWLPNETLEI IKTHLLAIKG PLETPVGGGI
110 120 130 140 150
RSLNVALRQE LDLFACVRPV RYFKGVPSPL KHPEKTAITI FRENTEDIYA
160 170 180 190 200
GIEWNAGTAE VQKVINFLQD DMQVKKIRFP KSSSIGIKPI SIEGSQRLIR
210 220 230 240 250
AAIEYALANN LTKVTLVHKG NIQKFTEGGF RKWGYELAKR EYAAELASGQ
260 270 280 290 300
LVVDDIIADN FLQQILLKPE RFDVVALTNL NGDYASDALA AQVGGIGISP
310 320 330 340 350
GANINYQTGH AIFEATHGTA PDIAGQDLAN PSSVLLSGCM LFDYIGWSKV
360 370 380 390
SDLIMKAVEK AIANGQVTID FAKELGVEAL TTRQFSEVLL TYL
Length:393
Mass (Da):43,141
Last modified:November 28, 2002 - v2
Checksum:i0F19F22A93D9DCD6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671N → K in AAC44826 (Ref. 1) Curated
Sequence conflicti383 – 3831R → C in AAC44826 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62799 Genomic DNA. Translation: AAC44826.1.
AE014133 Genomic DNA. Translation: AAN58406.1.
U48886 Genomic DNA. Translation: AAC44503.1.
RefSeqiNP_721100.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58406; AAN58406; SMU_672.
GeneIDi1028090.
KEGGismu:SMU_672.
PATRICi19663529. VBIStrMut61772_0597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62799 Genomic DNA. Translation: AAC44826.1.
AE014133 Genomic DNA. Translation: AAN58406.1.
U48886 Genomic DNA. Translation: AAC44503.1.
RefSeqiNP_721100.1. NC_004350.2.

3D structure databases

ProteinModelPortaliQ59940.
SMRiQ59940. Positions 2-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU.672.

Proteomic databases

PRIDEiQ59940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58406; AAN58406; SMU_672.
GeneIDi1028090.
KEGGismu:SMU_672.
PATRICi19663529. VBIStrMut61772_0597.

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OMAiKGQNTAN.
OrthoDBiEOG6SNDTP.
PhylomeDBiQ59940.

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-656-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cvitkovitch D.G., Gutierrez J.A., Bleiweis A.S.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JH1005.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.
  3. Gutierrez J.A., Crowley P.J., Brown D.P., Hillman J.D., Youngman P., Bleiweis A.S.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-224.
    Strain: JH1005.

Entry informationi

Entry nameiIDH_STRMU
AccessioniPrimary (citable) accession number: Q59940
Secondary accession number(s): Q59927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: January 7, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.