Reviewed, UniProtKB/Swiss-Prot Q59940 (IDH_STRMU)

Names and origin

Protein names

Recommended name:
    Isocitrate dehydrogenase [NADP]
      Short name=IDH
    EC=1.1.1.42
Alternative name(s):
    Oxalosuccinate decarboxylase
    NADP(+)-specific ICDH
    IDP

Gene names

Name:	icd
Synonyms:	idh
Ordered Locus Names:	SMU_672

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH. Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Ontologies

Keywords
Biological process	Glyoxylate bypass Tricarboxylic acid cycle
Ligand	Magnesium Manganese Metal-binding NADP
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Isocitrate dehydrogenase [NADP]		PRO_0000083568
Sites
	Metal binding	283	1	Magnesium or manganese By similarity
	Binding site	102	1	Substrate By similarity
	Binding site	104	1	Substrate By similarity
	Binding site	108	1	Substrate By similarity
	Binding site	118	1	Substrate By similarity
	Binding site	142	1	Substrate By similarity
	Site	149	1	Critical for catalysis By similarity
	Site	219	1	Critical for catalysis By similarity
Amino acid modifications
	Modified residue	102	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	67	1	N → K in AAC44826. Ref.1
	Sequence conflict	383	1	R → C in AAC44826. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q59940-1 [UniParc]. Last modified November 28, 2002. Version 2. Checksum: 0F19F22A93D9DCD6	FASTA	393	43,141
	10 20 30 40 50 60 MAEKVSFEEG KLQVPDKPVI PYIEGDGVGQ DIWKNAQIVF DKAIAKVYGG HKQVIWREVL 70 80 90 100 110 120 AGKKAYNETG NWLPNETLEI IKTHLLAIKG PLETPVGGGI RSLNVALRQE LDLFACVRPV 130 140 150 160 170 180 RYFKGVPSPL KHPEKTAITI FRENTEDIYA GIEWNAGTAE VQKVINFLQD DMQVKKIRFP 190 200 210 220 230 240 KSSSIGIKPI SIEGSQRLIR AAIEYALANN LTKVTLVHKG NIQKFTEGGF RKWGYELAKR 250 260 270 280 290 300 EYAAELASGQ LVVDDIIADN FLQQILLKPE RFDVVALTNL NGDYASDALA AQVGGIGISP 310 320 330 340 350 360 GANINYQTGH AIFEATHGTA PDIAGQDLAN PSSVLLSGCM LFDYIGWSKV SDLIMKAVEK 370 380 390 AIANGQVTID FAKELGVEAL TTRQFSEVLL TYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Cvitkovitch D.G., Gutierrez J.A., Bleiweis A.S. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: JH1005.
[2]	"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.
[3]	Gutierrez J.A., Crowley P.J., Brown D.P., Hillman J.D., Youngman P., Bleiweis A.S. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-224. Strain: JH1005.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U62799 Genomic DNA. Translation: AAC44826.1. AE014133 Genomic DNA. Translation: AAN58406.1. U48886 Genomic DNA. Translation: AAC44503.1.
RefSeq	NP_721100.1.
3D structure databases
HSSP	HSSP built from PDB template 1HQS based on UniProtKB P39126.
ModBase	Search...
Genome annotation databases
GeneID	1028090.
GenomeReviews	Gene locus SMU_672 in contig AE014133_GR.
KEGG	smu:SMU.672.
NMPDR	fig|210007.1.peg.613.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q59940.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_672-MON.
Family and domain databases
InterPro	IPR004439. IsoCit_DHase_NADP_prok. IPR001804. IsoCit_IM_DHase. [Graphical view]
Gene3D	G3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHER	PTHR11835. IDH_IMDH_dimeric. 1 hit. PTHR11835:SF1. NADP_IDH_prok. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IDH_STRMU

Accession

Primary (citable) accession number: Q59940
Secondary accession number(s): Q59927

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 28, 2002
Last modified:	November 25, 2008
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)