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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102SubstrateBy similarity1
Binding sitei104SubstrateBy similarity1
Binding sitei108SubstrateBy similarity1
Binding sitei118SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Sitei149Critical for catalysisBy similarity1
Sitei219Critical for catalysisBy similarity1
Metal bindingi283Magnesium or manganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Synonyms:idh
Ordered Locus Names:SMU_672
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835681 – 393Isocitrate dehydrogenase [NADP]Add BLAST393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ59940.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi210007.SMU_672.

Structurei

3D structure databases

ProteinModelPortaliQ59940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
KOiK00031.
OMAiDMRVEGA.
PhylomeDBiQ59940.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 2 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKVSFEEG KLQVPDKPVI PYIEGDGVGQ DIWKNAQIVF DKAIAKVYGG
60 70 80 90 100
HKQVIWREVL AGKKAYNETG NWLPNETLEI IKTHLLAIKG PLETPVGGGI
110 120 130 140 150
RSLNVALRQE LDLFACVRPV RYFKGVPSPL KHPEKTAITI FRENTEDIYA
160 170 180 190 200
GIEWNAGTAE VQKVINFLQD DMQVKKIRFP KSSSIGIKPI SIEGSQRLIR
210 220 230 240 250
AAIEYALANN LTKVTLVHKG NIQKFTEGGF RKWGYELAKR EYAAELASGQ
260 270 280 290 300
LVVDDIIADN FLQQILLKPE RFDVVALTNL NGDYASDALA AQVGGIGISP
310 320 330 340 350
GANINYQTGH AIFEATHGTA PDIAGQDLAN PSSVLLSGCM LFDYIGWSKV
360 370 380 390
SDLIMKAVEK AIANGQVTID FAKELGVEAL TTRQFSEVLL TYL
Length:393
Mass (Da):43,141
Last modified:November 28, 2002 - v2
Checksum:i0F19F22A93D9DCD6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67N → K in AAC44826 (Ref. 1) Curated1
Sequence conflicti383R → C in AAC44826 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62799 Genomic DNA. Translation: AAC44826.1.
AE014133 Genomic DNA. Translation: AAN58406.1.
U48886 Genomic DNA. Translation: AAC44503.1.
RefSeqiNP_721100.1. NC_004350.2.
WP_002261869.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58406; AAN58406; SMU_672.
GeneIDi1028090.
KEGGismu:SMU_672.
PATRICi19663529. VBIStrMut61772_0597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62799 Genomic DNA. Translation: AAC44826.1.
AE014133 Genomic DNA. Translation: AAN58406.1.
U48886 Genomic DNA. Translation: AAC44503.1.
RefSeqiNP_721100.1. NC_004350.2.
WP_002261869.1. NC_004350.2.

3D structure databases

ProteinModelPortaliQ59940.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_672.

Proteomic databases

PRIDEiQ59940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58406; AAN58406; SMU_672.
GeneIDi1028090.
KEGGismu:SMU_672.
PATRICi19663529. VBIStrMut61772_0597.

Phylogenomic databases

eggNOGiENOG4108HMX. Bacteria.
COG0538. LUCA.
KOiK00031.
OMAiDMRVEGA.
PhylomeDBiQ59940.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 2 hits.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIDH_STRMU
AccessioniPrimary (citable) accession number: Q59940
Secondary accession number(s): Q59927
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.