Reviewed,
UniProtKB/Swiss-Prot Q59940 (IDH_STRMU)
Last modified
November 25, 2008.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Isocitrate dehydrogenase [NADP] Short name=IDH EC=1.1.1.42 Alternative name(s): Oxalosuccinate decarboxylase NADP(+)-specific ICDH IDP | ||||||
| Gene names |
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| Organism | Streptococcus mutans [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1309 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus |
Protein attributes
| Sequence length | 393 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH. Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH. |
| Cofactor | Binds 1 magnesium or manganese ion per subunit By similarity. |
| Subunit structure | Homodimer By similarity. |
| Sequence similarities | Belongs to the isocitrate and isopropylmalate dehydrogenases family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Glyoxylate bypass Tricarboxylic acid cycle |
| Ligand | Magnesium Manganese Metal-binding NADP |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycleInferred from electronic annotation. Source: InterPro |
| Molecular function | isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW manganese ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 393 | 393 | Isocitrate dehydrogenase [NADP] | PRO_0000083568 | |||||
Sites | |||||||||
| Metal binding | 283 | 1 | Magnesium or manganese By similarity | ||||||
| Binding site | 102 | 1 | Substrate By similarity | ||||||
| Binding site | 104 | 1 | Substrate By similarity | ||||||
| Binding site | 108 | 1 | Substrate By similarity | ||||||
| Binding site | 118 | 1 | Substrate By similarity | ||||||
| Binding site | 142 | 1 | Substrate By similarity | ||||||
| Site | 149 | 1 | Critical for catalysis By similarity | ||||||
| Site | 219 | 1 | Critical for catalysis By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 102 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 67 | 1 | N → K in AAC44826. Ref.1 | ||||||
| Sequence conflict | 383 | 1 | R → C in AAC44826. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Cvitkovitch D.G., Gutierrez J.A., Bleiweis A.S. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: JH1005. |
| [2] | "Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c. |
| [3] | Gutierrez J.A., Crowley P.J., Brown D.P., Hillman J.D., Youngman P., Bleiweis A.S. Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-224. Strain: JH1005. |
Cross-references
Sequence databases | |
|---|---|
| U62799 Genomic DNA. Translation: AAC44826.1. AE014133 Genomic DNA. Translation: AAN58406.1. U48886 Genomic DNA. Translation: AAC44503.1. | |
| RefSeq | NP_721100.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HQS based on UniProtKB P39126. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1028090. |
| GenomeReviews | Gene locus SMU_672 in contig AE014133_GR. |
| KEGG | smu:SMU.672. |
| NMPDR | fig|210007.1.peg.613. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q59940. |
Enzyme and pathway databases | |
| BioCyc | SMUT210007:SMU_672-MON. |
Family and domain databases | |
| InterPro | IPR004439. IsoCit_DHase_NADP_prok. IPR001804. IsoCit_IM_DHase. [Graphical view] |
| Gene3D | G3DSA:3.40.718.10. IDH_IMDH. 1 hit. |
| PANTHER | PTHR11835. IDH_IMDH_dimeric. 1 hit. PTHR11835:SF1. NADP_IDH_prok. 1 hit. |
| Pfam | PF00180. Iso_dh. 1 hit. [Graphical view] |
| PROSITE | PS00470. IDH_IMDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IDH_STRMU | ||||||||
| Accession | Primary (citable) accession number: Q59940 Secondary accession number(s): Q59927 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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