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Q59939

- CISY_STRMU

UniProt

Q59939 - CISY_STRMU

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Protein

Citrate synthase

Gene

citZ

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei258 – 2581PROSITE-ProRule annotation
Active sitei309 – 3091PROSITE-ProRule annotation

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-655-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:citZ
Ordered Locus Names:SMU_671
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Citrate synthasePRO_0000169973Add
BLAST

Proteomic databases

PRIDEiQ59939.

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.671.

Structurei

3D structure databases

ProteinModelPortaliQ59939.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0372.
KOiK01647.
OMAiTNDEQIG.
OrthoDBiEOG6P8TP4.
PhylomeDBiQ59939.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR011278. 2-MeCitrate/Citrate_synth_II.
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01800. cit_synth_II. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59939-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAETNGLKDM IACDTRISAI KDNKLSYAGY DIADLMDNKA RFEEVIYLLW
60 70 80 90 100
NLHLPTAIEL KQFEEKLRKN YAISDAIEQC ILIQSRQHLH PMSVLRSTVS
110 120 130 140 150
LLGVYNLKAE ERSVEATYDQ SIQLMAKIPT IIATFARLRQ GLSPIAPRKD
160 170 180 190 200
LGFAANFLYM LNGRLPSELE ILAMNRALVL HAEHELNAST FAARVCASTL
210 220 230 240 250
SDIYSCVTTA IGTLKGPLHG GANERVFDML REIREYGDVD SYLQEKLNSK
260 270 280 290 300
EKIMGFGHRV YQTQDPREKY LREMARELTK GTEHDIWYQL SKKVEICMKQ
310 320 330 340 350
KKNLIPNVDF YSATVYHVLG IDSSIFTLIF AMSRVSGWIA HIQEQQKNNK
360 370
LIRPRSHYTG MRKLRYIPIE RR
Length:372
Mass (Da):42,711
Last modified:November 28, 2002 - v2
Checksum:iAC0EBA6DB6B847D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401A → T in AAC44825. (PubMed:9006016)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62799 Genomic DNA. Translation: AAC44825.1.
AE014133 Genomic DNA. Translation: AAN58405.1.
RefSeqiNP_721099.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58405; AAN58405; SMU_671.
GeneIDi1029598.
KEGGismu:SMU_671.
PATRICi19663527. VBIStrMut61772_0596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62799 Genomic DNA. Translation: AAC44825.1 .
AE014133 Genomic DNA. Translation: AAN58405.1 .
RefSeqi NP_721099.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q59939.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.671.

Proteomic databases

PRIDEi Q59939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58405 ; AAN58405 ; SMU_671 .
GeneIDi 1029598.
KEGGi smu:SMU_671.
PATRICi 19663527. VBIStrMut61772_0596.

Phylogenomic databases

eggNOGi COG0372.
KOi K01647.
OMAi TNDEQIG.
OrthoDBi EOG6P8TP4.
PhylomeDBi Q59939.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci SMUT210007:GC7Z-655-MONOMER.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR011278. 2-MeCitrate/Citrate_synth_II.
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01800. cit_synth_II. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans."
    Cvitkovitch D.G., Gutierrez J.A., Bleiweis A.S.
    J. Bacteriol. 179:650-655(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JH1005.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiCISY_STRMU
AccessioniPrimary (citable) accession number: Q59939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: October 1, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3