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Q59939

- CISY_STRMU

UniProt

Q59939 - CISY_STRMU

Protein

Citrate synthase

Gene

citZ

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (28 Nov 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei258 – 2581PROSITE-ProRule annotation
    Active sitei309 – 3091PROSITE-ProRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-655-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:citZ
    Ordered Locus Names:SMU_671
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Citrate synthasePRO_0000169973Add
    BLAST

    Proteomic databases

    PRIDEiQ59939.

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.671.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59939.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    KOiK01647.
    OMAiTNDEQIG.
    OrthoDBiEOG6P8TP4.
    PhylomeDBiQ59939.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR011278. 2-MeCitrate/Citrate_synth_II.
    IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01800. cit_synth_II. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59939-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETNGLKDM IACDTRISAI KDNKLSYAGY DIADLMDNKA RFEEVIYLLW    50
    NLHLPTAIEL KQFEEKLRKN YAISDAIEQC ILIQSRQHLH PMSVLRSTVS 100
    LLGVYNLKAE ERSVEATYDQ SIQLMAKIPT IIATFARLRQ GLSPIAPRKD 150
    LGFAANFLYM LNGRLPSELE ILAMNRALVL HAEHELNAST FAARVCASTL 200
    SDIYSCVTTA IGTLKGPLHG GANERVFDML REIREYGDVD SYLQEKLNSK 250
    EKIMGFGHRV YQTQDPREKY LREMARELTK GTEHDIWYQL SKKVEICMKQ 300
    KKNLIPNVDF YSATVYHVLG IDSSIFTLIF AMSRVSGWIA HIQEQQKNNK 350
    LIRPRSHYTG MRKLRYIPIE RR 372
    Length:372
    Mass (Da):42,711
    Last modified:November 28, 2002 - v2
    Checksum:iAC0EBA6DB6B847D3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401A → T in AAC44825. (PubMed:9006016)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62799 Genomic DNA. Translation: AAC44825.1.
    AE014133 Genomic DNA. Translation: AAN58405.1.
    RefSeqiNP_721099.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN58405; AAN58405; SMU_671.
    GeneIDi1029598.
    KEGGismu:SMU_671.
    PATRICi19663527. VBIStrMut61772_0596.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62799 Genomic DNA. Translation: AAC44825.1 .
    AE014133 Genomic DNA. Translation: AAN58405.1 .
    RefSeqi NP_721099.1. NC_004350.2.

    3D structure databases

    ProteinModelPortali Q59939.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.671.

    Proteomic databases

    PRIDEi Q59939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN58405 ; AAN58405 ; SMU_671 .
    GeneIDi 1029598.
    KEGGi smu:SMU_671.
    PATRICi 19663527. VBIStrMut61772_0596.

    Phylogenomic databases

    eggNOGi COG0372.
    KOi K01647.
    OMAi TNDEQIG.
    OrthoDBi EOG6P8TP4.
    PhylomeDBi Q59939.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci SMUT210007:GC7Z-655-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR011278. 2-MeCitrate/Citrate_synth_II.
    IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01800. cit_synth_II. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans."
      Cvitkovitch D.G., Gutierrez J.A., Bleiweis A.S.
      J. Bacteriol. 179:650-655(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: JH1005.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.

    Entry informationi

    Entry nameiCISY_STRMU
    AccessioniPrimary (citable) accession number: Q59939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 28, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3