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Q59939

- CISY_STRMU

UniProt

Q59939 - CISY_STRMU

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Protein

Citrate synthase

Gene
citZ, SMU_671
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei258 – 2581 By similarity
Active sitei309 – 3091 By similarity

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-655-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:citZ
Ordered Locus Names:SMU_671
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Citrate synthasePRO_0000169973Add
BLAST

Proteomic databases

PRIDEiQ59939.

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.671.

Structurei

3D structure databases

ProteinModelPortaliQ59939.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Phylogenomic databases

eggNOGiCOG0372.
KOiK01647.
OMAiTNDEQIG.
OrthoDBiEOG6P8TP4.
PhylomeDBiQ59939.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR011278. 2-MeCitrate/Citrate_synth_II.
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01800. cit_synth_II. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59939-1 [UniParc]FASTAAdd to Basket

« Hide

MAETNGLKDM IACDTRISAI KDNKLSYAGY DIADLMDNKA RFEEVIYLLW    50
NLHLPTAIEL KQFEEKLRKN YAISDAIEQC ILIQSRQHLH PMSVLRSTVS 100
LLGVYNLKAE ERSVEATYDQ SIQLMAKIPT IIATFARLRQ GLSPIAPRKD 150
LGFAANFLYM LNGRLPSELE ILAMNRALVL HAEHELNAST FAARVCASTL 200
SDIYSCVTTA IGTLKGPLHG GANERVFDML REIREYGDVD SYLQEKLNSK 250
EKIMGFGHRV YQTQDPREKY LREMARELTK GTEHDIWYQL SKKVEICMKQ 300
KKNLIPNVDF YSATVYHVLG IDSSIFTLIF AMSRVSGWIA HIQEQQKNNK 350
LIRPRSHYTG MRKLRYIPIE RR 372
Length:372
Mass (Da):42,711
Last modified:November 28, 2002 - v2
Checksum:iAC0EBA6DB6B847D3
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401A → T in AAC44825. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62799 Genomic DNA. Translation: AAC44825.1.
AE014133 Genomic DNA. Translation: AAN58405.1.
RefSeqiNP_721099.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58405; AAN58405; SMU_671.
GeneIDi1029598.
KEGGismu:SMU_671.
PATRICi19663527. VBIStrMut61772_0596.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62799 Genomic DNA. Translation: AAC44825.1 .
AE014133 Genomic DNA. Translation: AAN58405.1 .
RefSeqi NP_721099.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q59939.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.671.

Proteomic databases

PRIDEi Q59939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58405 ; AAN58405 ; SMU_671 .
GeneIDi 1029598.
KEGGi smu:SMU_671.
PATRICi 19663527. VBIStrMut61772_0596.

Phylogenomic databases

eggNOGi COG0372.
KOi K01647.
OMAi TNDEQIG.
OrthoDBi EOG6P8TP4.
PhylomeDBi Q59939.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci SMUT210007:GC7Z-655-MONOMER.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR011278. 2-MeCitrate/Citrate_synth_II.
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01800. cit_synth_II. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans."
    Cvitkovitch D.G., Gutierrez J.A., Bleiweis A.S.
    J. Bacteriol. 179:650-655(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JH1005.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiCISY_STRMU
AccessioniPrimary (citable) accession number: Q59939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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