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Q59939 (CISY_STRMU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:citZ
Ordered Locus Names:SMU_671
OrganismStreptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]
Taxonomic identifier210007 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Citrate synthase
PRO_0000169973

Sites

Active site2581 By similarity
Active site3091 By similarity

Experimental info

Sequence conflict401A → T in AAC44825. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q59939 [UniParc].

Last modified November 28, 2002. Version 2.
Checksum: AC0EBA6DB6B847D3

FASTA37242,711
        10         20         30         40         50         60 
MAETNGLKDM IACDTRISAI KDNKLSYAGY DIADLMDNKA RFEEVIYLLW NLHLPTAIEL 

        70         80         90        100        110        120 
KQFEEKLRKN YAISDAIEQC ILIQSRQHLH PMSVLRSTVS LLGVYNLKAE ERSVEATYDQ 

       130        140        150        160        170        180 
SIQLMAKIPT IIATFARLRQ GLSPIAPRKD LGFAANFLYM LNGRLPSELE ILAMNRALVL 

       190        200        210        220        230        240 
HAEHELNAST FAARVCASTL SDIYSCVTTA IGTLKGPLHG GANERVFDML REIREYGDVD 

       250        260        270        280        290        300 
SYLQEKLNSK EKIMGFGHRV YQTQDPREKY LREMARELTK GTEHDIWYQL SKKVEICMKQ 

       310        320        330        340        350        360 
KKNLIPNVDF YSATVYHVLG IDSSIFTLIF AMSRVSGWIA HIQEQQKNNK LIRPRSHYTG 

       370 
MRKLRYIPIE RR 

« Hide

References

« Hide 'large scale' references
[1]"Role of the citrate pathway in glutamate biosynthesis by Streptococcus mutans."
Cvitkovitch D.G., Gutierrez J.A., Bleiweis A.S.
J. Bacteriol. 179:650-655(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: JH1005.
[2]"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen."
Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.
Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700610 / UA159.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U62799 Genomic DNA. Translation: AAC44825.1.
AE014133 Genomic DNA. Translation: AAN58405.1.
RefSeqNP_721099.1. NC_004350.2.

3D structure databases

ProteinModelPortalQ59939.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING210007.SMU.671.

Proteomic databases

PRIDEQ59939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN58405; AAN58405; SMU_671.
GeneID1029598.
KEGGsmu:SMU_671.
PATRIC19663527. VBIStrMut61772_0596.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0372.
KOK01647.
OMAVYHSLGI.
OrthoDBEOG6P8TP4.
ProtClustDBPRK14035.

Enzyme and pathway databases

BioCycSMUT210007:GC7Z-655-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR011278. 2-MeCitrate/Citrate_synth_I.
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01800. cit_synth_II. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_STRMU
AccessionPrimary (citable) accession number: Q59939
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: November 13, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways