Q59935 (MANA_STRMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-6-phosphate isomerase
EC=5.3.1.8

Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name=PMI

Gene names

Name:	pmi
Synonyms:	manA
Ordered Locus Names:	SMU_1839

Organism

Streptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]

Taxonomic identifier

210007 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus mutans

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannose 6-phosphate = D-fructose 6-phosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the mannose-6-phosphate isomerase type 1 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	mannose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Mannose-6-phosphate isomerase		PRO_0000194229
Sites
	Active site	191	1	By similarity
	Metal binding	95	1	Zinc By similarity
	Metal binding	97	1	Zinc By similarity
	Metal binding	114	1	Zinc By similarity
	Metal binding	171	1	Zinc By similarity
Experimental info
	Sequence conflict	2 – 3	2	AE → EG in BAA04021. Ref.1
	Sequence conflict	175	1	K → R in BAA04021. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q59935 [UniParc]. Last modified November 28, 2002. Version 2. Checksum: 1DBF0411DA6CCF33	FASTA	316	35,374
	10 20 30 40 50 60 MAEPLFLQSQ MHKKIWGGNR LRKEFGYDIP SETTGEYWAI SAHPNGVSVV KNGVYKGVPL 70 80 90 100 110 120 DELYAEHREL FGNSKSSVFP LLTKILDAND WLSVQVHPDN AYALEHEGEL GKTECWYVIS 130 140 150 160 170 180 ADEGAEIIYG HEAKSKEELR QMIAAGDWDH LLTKIPVKAG DFFYVPSGTM HAIGKGIMIL 190 200 210 220 230 240 ETQQSSDTTY RVYDFDRKDD QGRKRALHIE QSIDVLTIGK PANATPAWLS LQGLETTVLV 250 260 270 280 290 300 SSPFFTVYKW QISGSVKMQQ TAPYLLVSVL AGQGRITVGL EQYALRKGDH LILPNTIKSW 310 QFDGDLEIIA SHSNEC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequence analysis of the pmi gene encoding phosphomannose isomerase of Streptococcus mutans." Sato Y., Yamamoto Y., Kizaki H., Kuramitsu H.K. FEMS Microbiol. Lett. 114:61-66(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: GS-5.
[2]	"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D16594 Genomic DNA. Translation: BAA04021.1. AE014133 Genomic DNA. Translation: AAN59462.1.
RefSeq	NP_722156.1. NC_004350.2.
3D structure databases
ProteinModelPortal	Q59935.
SMR	Q59935. Positions 2-312.
ModBase	Search...
Protein-protein interaction databases
STRING	210007.SMU.1839.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN59462; AAN59462; SMU_1839.
GeneID	1029052.
KEGG	smu:SMU_1839.
PATRIC	19665675. VBIStrMut61772_1642.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1482.
KO	K01809.
OMA	VIETQQS.
ProtClustDB	CLSK698862.
Enzyme and pathway databases
BioCyc	SMUT210007:GC7Z-1741-MONOMER.
Family and domain databases
Gene3D	2.60.120.10. 2 hits.
InterPro	IPR001250. Man6P_Isoase-1. IPR014628. Man6P_isomerase_Firm_short. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
PANTHER	PTHR18964:SF1. PTHR18964:SF1. 1 hit.
Pfam	PF01238. PMI_typeI. 1 hit. [Graphical view]
PIRSF	PIRSF036894. PMI_Firm_short. 1 hit.
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR00218. manA. 1 hit.
PROSITE	PS00965. PMI_I_1. False negative. PS00966. PMI_I_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MANA_STRMU

Accession

Primary (citable) accession number: Q59935

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 28, 2002
Last modified:	May 29, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program