Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q59935

- MANA_STRMU

UniProt

Q59935 - MANA_STRMU

Protein

Mannose-6-phosphate isomerase

Gene

pmi

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (28 Nov 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    D-mannose 6-phosphate = D-fructose 6-phosphate.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi95 – 951ZincBy similarity
    Metal bindingi97 – 971ZincBy similarity
    Metal bindingi114 – 1141ZincBy similarity
    Metal bindingi171 – 1711ZincBy similarity
    Active sitei191 – 1911By similarity

    GO - Molecular functioni

    1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-1741-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-6-phosphate isomerase (EC:5.3.1.8)
    Alternative name(s):
    Phosphohexomutase
    Phosphomannose isomerase
    Short name:
    PMI
    Gene namesi
    Name:pmi
    Synonyms:manA
    Ordered Locus Names:SMU_1839
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Mannose-6-phosphate isomerasePRO_0000194229Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.1839.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59935.
    SMRiQ59935. Positions 2-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1482.
    KOiK01809.
    OMAiPKAKEFP.
    OrthoDBiEOG66MQQS.
    PhylomeDBiQ59935.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    InterProiIPR001250. Man6P_Isoase-1.
    IPR014628. Man6P_isomerase_Firm_short.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF01238. PMI_typeI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036894. PMI_Firm_short. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR00218. manA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59935-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEPLFLQSQ MHKKIWGGNR LRKEFGYDIP SETTGEYWAI SAHPNGVSVV    50
    KNGVYKGVPL DELYAEHREL FGNSKSSVFP LLTKILDAND WLSVQVHPDN 100
    AYALEHEGEL GKTECWYVIS ADEGAEIIYG HEAKSKEELR QMIAAGDWDH 150
    LLTKIPVKAG DFFYVPSGTM HAIGKGIMIL ETQQSSDTTY RVYDFDRKDD 200
    QGRKRALHIE QSIDVLTIGK PANATPAWLS LQGLETTVLV SSPFFTVYKW 250
    QISGSVKMQQ TAPYLLVSVL AGQGRITVGL EQYALRKGDH LILPNTIKSW 300
    QFDGDLEIIA SHSNEC 316
    Length:316
    Mass (Da):35,374
    Last modified:November 28, 2002 - v2
    Checksum:i1DBF0411DA6CCF33
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 32AE → EG in BAA04021. (PubMed:8293960)Curated
    Sequence conflicti175 – 1751K → R in BAA04021. (PubMed:8293960)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16594 Genomic DNA. Translation: BAA04021.1.
    AE014133 Genomic DNA. Translation: AAN59462.1.
    RefSeqiNP_722156.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN59462; AAN59462; SMU_1839.
    GeneIDi1029052.
    KEGGismu:SMU_1839.
    PATRICi19665675. VBIStrMut61772_1642.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16594 Genomic DNA. Translation: BAA04021.1 .
    AE014133 Genomic DNA. Translation: AAN59462.1 .
    RefSeqi NP_722156.1. NC_004350.2.

    3D structure databases

    ProteinModelPortali Q59935.
    SMRi Q59935. Positions 2-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.1839.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN59462 ; AAN59462 ; SMU_1839 .
    GeneIDi 1029052.
    KEGGi smu:SMU_1839.
    PATRICi 19665675. VBIStrMut61772_1642.

    Phylogenomic databases

    eggNOGi COG1482.
    KOi K01809.
    OMAi PKAKEFP.
    OrthoDBi EOG66MQQS.
    PhylomeDBi Q59935.

    Enzyme and pathway databases

    BioCyci SMUT210007:GC7Z-1741-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    InterProi IPR001250. Man6P_Isoase-1.
    IPR014628. Man6P_isomerase_Firm_short.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF01238. PMI_typeI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036894. PMI_Firm_short. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR00218. manA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence analysis of the pmi gene encoding phosphomannose isomerase of Streptococcus mutans."
      Sato Y., Yamamoto Y., Kizaki H., Kuramitsu H.K.
      FEMS Microbiol. Lett. 114:61-66(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: GS-5.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.

    Entry informationi

    Entry nameiMANA_STRMU
    AccessioniPrimary (citable) accession number: Q59935
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 28, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3