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Q59935

- MANA_STRMU

UniProt

Q59935 - MANA_STRMU

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Protein

Mannose-6-phosphate isomerase

Gene

pmi

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi95 – 951ZincBy similarity
Metal bindingi97 – 971ZincBy similarity
Metal bindingi114 – 1141ZincBy similarity
Metal bindingi171 – 1711ZincBy similarity
Active sitei191 – 1911By similarity

GO - Molecular functioni

  1. mannose-6-phosphate isomerase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1741-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:pmi
Synonyms:manA
Ordered Locus Names:SMU_1839
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Mannose-6-phosphate isomerasePRO_0000194229Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.1839.

Structurei

3D structure databases

ProteinModelPortaliQ59935.
SMRiQ59935. Positions 2-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1482.
KOiK01809.
OMAiPKAKEFP.
OrthoDBiEOG66MQQS.
PhylomeDBiQ59935.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR001250. Man6P_Isoase-1.
IPR014628. Man6P_isomerase_Firm_short.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF01238. PMI_typeI. 1 hit.
[Graphical view]
PIRSFiPIRSF036894. PMI_Firm_short. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59935-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEPLFLQSQ MHKKIWGGNR LRKEFGYDIP SETTGEYWAI SAHPNGVSVV
60 70 80 90 100
KNGVYKGVPL DELYAEHREL FGNSKSSVFP LLTKILDAND WLSVQVHPDN
110 120 130 140 150
AYALEHEGEL GKTECWYVIS ADEGAEIIYG HEAKSKEELR QMIAAGDWDH
160 170 180 190 200
LLTKIPVKAG DFFYVPSGTM HAIGKGIMIL ETQQSSDTTY RVYDFDRKDD
210 220 230 240 250
QGRKRALHIE QSIDVLTIGK PANATPAWLS LQGLETTVLV SSPFFTVYKW
260 270 280 290 300
QISGSVKMQQ TAPYLLVSVL AGQGRITVGL EQYALRKGDH LILPNTIKSW
310
QFDGDLEIIA SHSNEC
Length:316
Mass (Da):35,374
Last modified:November 28, 2002 - v2
Checksum:i1DBF0411DA6CCF33
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32AE → EG in BAA04021. (PubMed:8293960)Curated
Sequence conflicti175 – 1751K → R in BAA04021. (PubMed:8293960)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16594 Genomic DNA. Translation: BAA04021.1.
AE014133 Genomic DNA. Translation: AAN59462.1.
RefSeqiNP_722156.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59462; AAN59462; SMU_1839.
GeneIDi1029052.
KEGGismu:SMU_1839.
PATRICi19665675. VBIStrMut61772_1642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D16594 Genomic DNA. Translation: BAA04021.1 .
AE014133 Genomic DNA. Translation: AAN59462.1 .
RefSeqi NP_722156.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q59935.
SMRi Q59935. Positions 2-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1839.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN59462 ; AAN59462 ; SMU_1839 .
GeneIDi 1029052.
KEGGi smu:SMU_1839.
PATRICi 19665675. VBIStrMut61772_1642.

Phylogenomic databases

eggNOGi COG1482.
KOi K01809.
OMAi PKAKEFP.
OrthoDBi EOG66MQQS.
PhylomeDBi Q59935.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-1741-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
InterProi IPR001250. Man6P_Isoase-1.
IPR014628. Man6P_isomerase_Firm_short.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF01238. PMI_typeI. 1 hit.
[Graphical view ]
PIRSFi PIRSF036894. PMI_Firm_short. 1 hit.
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR00218. manA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence analysis of the pmi gene encoding phosphomannose isomerase of Streptococcus mutans."
    Sato Y., Yamamoto Y., Kizaki H., Kuramitsu H.K.
    FEMS Microbiol. Lett. 114:61-66(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GS-5.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiMANA_STRMU
AccessioniPrimary (citable) accession number: Q59935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: October 1, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3