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Protein

Mannose-6-phosphate isomerase

Gene

pmi

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi95ZincBy similarity1
Metal bindingi97ZincBy similarity1
Metal bindingi114ZincBy similarity1
Metal bindingi171ZincBy similarity1
Active sitei191By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
Name:pmi
Synonyms:manA
Ordered Locus Names:SMU_1839
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942291 – 316Mannose-6-phosphate isomeraseAdd BLAST316

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_1839.

Structurei

3D structure databases

ProteinModelPortaliQ59935.
SMRiQ59935.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105DG6. Bacteria.
COG1482. LUCA.
KOiK01809.
OMAiFRPKIWG.
PhylomeDBiQ59935.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiView protein in InterPro
IPR001250. Man6P_Isoase-1.
IPR014628. Man6P_isomerase_Firm_short.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin_sf.
PfamiView protein in Pfam
PF01238. PMI_typeI. 1 hit.
PIRSFiPIRSF036894. PMI_Firm_short. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR00218. manA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEPLFLQSQ MHKKIWGGNR LRKEFGYDIP SETTGEYWAI SAHPNGVSVV
60 70 80 90 100
KNGVYKGVPL DELYAEHREL FGNSKSSVFP LLTKILDAND WLSVQVHPDN
110 120 130 140 150
AYALEHEGEL GKTECWYVIS ADEGAEIIYG HEAKSKEELR QMIAAGDWDH
160 170 180 190 200
LLTKIPVKAG DFFYVPSGTM HAIGKGIMIL ETQQSSDTTY RVYDFDRKDD
210 220 230 240 250
QGRKRALHIE QSIDVLTIGK PANATPAWLS LQGLETTVLV SSPFFTVYKW
260 270 280 290 300
QISGSVKMQQ TAPYLLVSVL AGQGRITVGL EQYALRKGDH LILPNTIKSW
310
QFDGDLEIIA SHSNEC
Length:316
Mass (Da):35,374
Last modified:November 28, 2002 - v2
Checksum:i1DBF0411DA6CCF33
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3AE → EG in BAA04021 (PubMed:8293960).Curated2
Sequence conflicti175K → R in BAA04021 (PubMed:8293960).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16594 Genomic DNA. Translation: BAA04021.1.
AE014133 Genomic DNA. Translation: AAN59462.1.
RefSeqiNP_722156.1. NC_004350.2.
WP_002262655.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59462; AAN59462; SMU_1839.
GeneIDi1029052.
KEGGismu:SMU_1839.
PATRICifig|210007.7.peg.1642.

Similar proteinsi

Entry informationi

Entry nameiMANA_STRMU
AccessioniPrimary (citable) accession number: Q59935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: November 22, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families