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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:G1FZX-1021-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Synonyms:fthS
Ordered Locus Names:SMU_1073
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001993861 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Proteomic databases

PRIDEiQ59925

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_1073

Structurei

3D structure databases

ProteinModelPortaliQ59925
SMRiQ59925
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
KOiK01938
OMAiCGEIMTM
PhylomeDBiQ59925

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q59925-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDIEIAQS VDLRPITNVV KKLGFDFDDL ELYGKYKAKL TFDKIKAVEE
60 70 80 90 100
NAPGKLVLVT AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP
110 120 130 140 150
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ
160 170 180 190 200
GNELGIDQRR IIWKRVVDLN DRALRHVTVG LGSPINGIPR EDGFDITVAS
210 220 230 240 250
EIMAILCLAT NVEDLKERLA NIVIGYRFDR SPVYVRDLEV QGALALILKE
260 270 280 290 300
AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTITEAG
310 320 330 340 350
FGADLGAEKF LDIKAPNLPT SPDAVVIVAT IRALKMNGGV AKDALNQENV
360 370 380 390 400
EAVKAGFANL ARHVENMRKY GVPVVVAINE FITDTNDEIA VLRNLCAAID
410 420 430 440 450
VPVELASVWA NGADGGVDLA NTLINTIENN PSHYKRLYDN NLSVEEKVTE
460 470 480 490 500
IAKEIYRADK VIFEKKAKTQ IAQIVKNGWD NLPICMAKTQ YSFSDDPKLL
510 520 530 540 550
GAPTGFDITI RELVPKLGAG FIVALTGDVM TMPGLPKKPA ALNMDVAADG

TALGLF
Length:556
Mass (Da):59,734
Last modified:November 28, 2002 - v2
Checksum:iE86BE44B307C099D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25F → I in AAB49329 (PubMed:9045814).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39612 Genomic DNA Translation: AAB49329.1
AE014133 Genomic DNA Translation: AAN58771.1
U48882 Genomic DNA Translation: AAC44499.1
RefSeqiNP_721465.1, NC_004350.2
WP_002262267.1, NC_004350.2

Genome annotation databases

EnsemblBacteriaiAAN58771; AAN58771; SMU_1073
GeneIDi1028388
KEGGismu:SMU_1073
PATRICifig|210007.7.peg.960

Similar proteinsi

Entry informationi

Entry nameiFTHS_STRMU
AccessioniPrimary (citable) accession number: Q59925
Secondary accession number(s): Q59926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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