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Q59925

- FTHS_STRMU

UniProt

Q59925 - FTHS_STRMU

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, fthS, SMU_1073
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1021-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Synonyms:fthS
Ordered Locus Names:SMU_1073
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199386Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.1073.

Structurei

3D structure databases

ProteinModelPortaliQ59925.
SMRiQ59925. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiNTIVQRI.
OrthoDBiEOG6PCPSP.
PhylomeDBiQ59925.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59925-1 [UniParc]FASTAAdd to Basket

« Hide

MKTDIEIAQS VDLRPITNVV KKLGFDFDDL ELYGKYKAKL TFDKIKAVEE    50
NAPGKLVLVT AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP 100
VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ 150
GNELGIDQRR IIWKRVVDLN DRALRHVTVG LGSPINGIPR EDGFDITVAS 200
EIMAILCLAT NVEDLKERLA NIVIGYRFDR SPVYVRDLEV QGALALILKE 250
AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTITEAG 300
FGADLGAEKF LDIKAPNLPT SPDAVVIVAT IRALKMNGGV AKDALNQENV 350
EAVKAGFANL ARHVENMRKY GVPVVVAINE FITDTNDEIA VLRNLCAAID 400
VPVELASVWA NGADGGVDLA NTLINTIENN PSHYKRLYDN NLSVEEKVTE 450
IAKEIYRADK VIFEKKAKTQ IAQIVKNGWD NLPICMAKTQ YSFSDDPKLL 500
GAPTGFDITI RELVPKLGAG FIVALTGDVM TMPGLPKKPA ALNMDVAADG 550
TALGLF 556
Length:556
Mass (Da):59,734
Last modified:November 28, 2002 - v2
Checksum:iE86BE44B307C099D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251F → I in AAB49329. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39612 Genomic DNA. Translation: AAB49329.1.
AE014133 Genomic DNA. Translation: AAN58771.1.
U48882 Genomic DNA. Translation: AAC44499.1.
RefSeqiNP_721465.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58771; AAN58771; SMU_1073.
GeneIDi1028388.
KEGGismu:SMU_1073.
PATRICi19664255. VBIStrMut61772_0960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39612 Genomic DNA. Translation: AAB49329.1 .
AE014133 Genomic DNA. Translation: AAN58771.1 .
U48882 Genomic DNA. Translation: AAC44499.1 .
RefSeqi NP_721465.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q59925.
SMRi Q59925. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1073.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58771 ; AAN58771 ; SMU_1073 .
GeneIDi 1028388.
KEGGi smu:SMU_1073.
PATRICi 19664255. VBIStrMut61772_0960.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi NTIVQRI.
OrthoDBi EOG6PCPSP.
PhylomeDBi Q59925.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SMUT210007:GC7Z-1021-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic and physiologic analysis of a formyl-tetrahydrofolate synthetase mutant of Streptococcus mutans."
    Crowley P.J., Gutierrez J.A., Hillman J.D., Bleiweis A.S.
    J. Bacteriol. 179:1563-1572(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: JH1005.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.
  3. "Insertional mutagenesis and recovery of interrupted genes of Streptococcus mutans by using transposon Tn917: preliminary characterization of mutants displaying acid sensitivity and nutritional requirements."
    Gutierrez J.A., Crowley P.J., Brown D.P., Hillman J.D., Youngman P., Bleiweis A.S.
    J. Bacteriol. 178:4166-4175(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 139-296.
    Strain: NG8.

Entry informationi

Entry nameiFTHS_STRMU
AccessioniPrimary (citable) accession number: Q59925
Secondary accession number(s): Q59926
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 28, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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