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Q59925

- FTHS_STRMU

UniProt

Q59925 - FTHS_STRMU

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (28 Nov 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-1021-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Synonyms:fthS
    Ordered Locus Names:SMU_1073
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000199386Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.1073.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59925.
    SMRiQ59925. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiNTIVQRI.
    OrthoDBiEOG6PCPSP.
    PhylomeDBiQ59925.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59925-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQS VDLRPITNVV KKLGFDFDDL ELYGKYKAKL TFDKIKAVEE    50
    NAPGKLVLVT AINPTPAGEG KSTITIGLAD ALNKIGKKTM IAIREPSLGP 100
    VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ 150
    GNELGIDQRR IIWKRVVDLN DRALRHVTVG LGSPINGIPR EDGFDITVAS 200
    EIMAILCLAT NVEDLKERLA NIVIGYRFDR SPVYVRDLEV QGALALILKE 250
    AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATSTALR LADYTITEAG 300
    FGADLGAEKF LDIKAPNLPT SPDAVVIVAT IRALKMNGGV AKDALNQENV 350
    EAVKAGFANL ARHVENMRKY GVPVVVAINE FITDTNDEIA VLRNLCAAID 400
    VPVELASVWA NGADGGVDLA NTLINTIENN PSHYKRLYDN NLSVEEKVTE 450
    IAKEIYRADK VIFEKKAKTQ IAQIVKNGWD NLPICMAKTQ YSFSDDPKLL 500
    GAPTGFDITI RELVPKLGAG FIVALTGDVM TMPGLPKKPA ALNMDVAADG 550
    TALGLF 556
    Length:556
    Mass (Da):59,734
    Last modified:November 28, 2002 - v2
    Checksum:iE86BE44B307C099D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251F → I in AAB49329. (PubMed:9045814)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39612 Genomic DNA. Translation: AAB49329.1.
    AE014133 Genomic DNA. Translation: AAN58771.1.
    U48882 Genomic DNA. Translation: AAC44499.1.
    RefSeqiNP_721465.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN58771; AAN58771; SMU_1073.
    GeneIDi1028388.
    KEGGismu:SMU_1073.
    PATRICi19664255. VBIStrMut61772_0960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39612 Genomic DNA. Translation: AAB49329.1 .
    AE014133 Genomic DNA. Translation: AAN58771.1 .
    U48882 Genomic DNA. Translation: AAC44499.1 .
    RefSeqi NP_721465.1. NC_004350.2.

    3D structure databases

    ProteinModelPortali Q59925.
    SMRi Q59925. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.1073.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN58771 ; AAN58771 ; SMU_1073 .
    GeneIDi 1028388.
    KEGGi smu:SMU_1073.
    PATRICi 19664255. VBIStrMut61772_0960.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi NTIVQRI.
    OrthoDBi EOG6PCPSP.
    PhylomeDBi Q59925.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SMUT210007:GC7Z-1021-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic and physiologic analysis of a formyl-tetrahydrofolate synthetase mutant of Streptococcus mutans."
      Crowley P.J., Gutierrez J.A., Hillman J.D., Bleiweis A.S.
      J. Bacteriol. 179:1563-1572(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: JH1005.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.
    3. "Insertional mutagenesis and recovery of interrupted genes of Streptococcus mutans by using transposon Tn917: preliminary characterization of mutants displaying acid sensitivity and nutritional requirements."
      Gutierrez J.A., Crowley P.J., Brown D.P., Hillman J.D., Youngman P., Bleiweis A.S.
      J. Bacteriol. 178:4166-4175(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 139-296.
      Strain: NG8.

    Entry informationi

    Entry nameiFTHS_STRMU
    AccessioniPrimary (citable) accession number: Q59925
    Secondary accession number(s): Q59926
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 28, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3