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Q59919

- DHPS_STAHA

UniProt

Q59919 - DHPS_STAHA

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Protein

Dihydropteroate synthase

Gene
folP
Organism
Staphylococcus haemolyticus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide.

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111Magnesium By similarity
Binding sitei19 – 191Substrate By similarity
Binding sitei84 – 841Substrate By similarity
Binding sitei103 – 1031Substrate By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei203 – 2031Substrate By similarity
Binding sitei239 – 2391Substrate By similarity
Binding sitei241 – 2411Substrate By similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:folP
OrganismiStaphylococcus haemolyticus
Taxonomic identifieri1283 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Dihydropteroate synthasePRO_0000168229Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ59919.
SMRiQ59919. Positions 2-265.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 251251Pterin-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 522Substrate binding By similarity

Sequence similaritiesi

Belongs to the DHPS family.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59919-1 [UniParc]FASTAAdd to Basket

« Hide

MTKTKIIGIL NVTPDSFSDG GKYNSVDKAI ARAKEMIDEG VDIIDVGGVS    50
TRPGHTEVSL EEEMERVVPV VEQLVKLDVQ ISVDTYRSEV AEACLKLGAT 100
MINDQWAGLY DPKIFDVVSD YNAEIVLMHN GDGQREQPVV EEMLLSLLTQ 150
ANKAEMAGIE KGNIWLDPGI GFAKSRSEEK EVMARLDELV ATEYPVLLAT 200
SRKRFIKEMI GKETTPAERD EATAATTVYG IMKGIQAVRV HNVDLNVKLA 250
QSIDFLKENE HERHHLS 267
Length:267
Mass (Da):29,613
Last modified:November 1, 1996 - v1
Checksum:i87807DFB3FBA8CBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40768 Genomic DNA. Translation: AAC43583.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U40768 Genomic DNA. Translation: AAC43583.1 .

3D structure databases

ProteinModelPortali Q59919.
SMRi Q59919. Positions 2-265.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional cloning of the dihydropteroate synthase gene of Staphylococcus haemolyticus."
    Kellam P., Dallas W.S., Ballantine S.P., Delves C.J.
    FEMS Microbiol. Lett. 134:165-169(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHPS_STAHA
AccessioniPrimary (citable) accession number: Q59919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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