Q59918 (CYSK_STAHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine synthase
Short name=CSase
EC=2.5.1.47

Alternative name(s):
O-acetylserine (thiol)-lyase
Short name=OAS-TL
O-acetylserine sulfhydrylase

Gene names

Name:

cysK

Organism

Staphylococcus haemolyticus

Taxonomic identifier

1283 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	155 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	O(3)-acetyl-L-serine + H2S = L-cysteine + acetate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cysteine synthase/cystathionine beta-synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Gene Ontology (GO)
Molecular function	cysteine synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 155	›155	Cysteine synthase		PRO_0000167103
Regions
	Region	25 – 29	5	Pyridoxal phosphate binding By similarity
Sites
	Binding site	113	1	Pyridoxal phosphate By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q59918 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 609CF880E5826BBA	FASTA	155	16,121
	10 20 30 40 50 60 ELTTGPEIVE QFEGKQIDAF LAGVGTGGTL SGAGKVLKEK YPNIEIVAIE PEASPVLSGG 70 80 90 100 110 120 EPGPHKLQGL GAGFVPDTLN TDIYDSIIQV GNDIAMETSR RVAKEEGILA GISSGAAIHA 130 140 150 AIQKAKELGK GKTVLTVLPS NGERYLSTPL YSFDD

References

[1]	"Functional cloning of the dihydropteroate synthase gene of Staphylococcus haemolyticus." Kellam P., Dallas W.S., Ballantine S.P., Delves C.J. FEMS Microbiol. Lett. 134:165-169(1995) [PubMed: 8586264] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40768 Genomic DNA. Translation: AAC43582.1.
3D structure databases
ProteinModelPortal	Q59918.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001926. PyrdxlP-dep_enz_bsu. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
SUPFAM	SSF53686. PyrdxlP-dep_enz_bsu. 1 hit.
PROSITE	PS00901. CYS_SYNTHASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSK_STAHA

Accession

Primary (citable) accession number: Q59918

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	September 21, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program