Reviewed, UniProtKB/Swiss-Prot Q59918 (CYSK_STAHA)

Names and origin

Protein names

Recommended name:
    Cysteine synthase
      Short name=CSase
    EC=2.5.1.47
Alternative name(s):
    O-acetylserine sulfhydrylase
    O-acetylserine (thiol)-lyase
      Short name=OAS-TL

Gene names

Name:

cysK

Organism

Staphylococcus haemolyticus

Taxonomic identifier

1283 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	155 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	O(3)-acetyl-L-serine + H2S = L-cysteine + acetate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cysteine synthase/cystathionine beta-synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Cysteine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Gene Ontology (GO)
Biological process	cysteine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cysteine synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 155	›155	Cysteine synthase		PRO_0000167103
Regions
	Region	25 – 29	5	Pyridoxal phosphate binding By similarity
Sites
	Binding site	113	1	Pyridoxal phosphate By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q59918-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 609CF880E5826BBA	FASTA	155	16,121
	10 20 30 40 50 60 ELTTGPEIVE QFEGKQIDAF LAGVGTGGTL SGAGKVLKEK YPNIEIVAIE PEASPVLSGG 70 80 90 100 110 120 EPGPHKLQGL GAGFVPDTLN TDIYDSIIQV GNDIAMETSR RVAKEEGILA GISSGAAIHA 130 140 150 AIQKAKELGK GKTVLTVLPS NGERYLSTPL YSFDD

References

[1]	"Functional cloning of the dihydropteroate synthase gene of Staphylococcus haemolyticus." Kellam P., Dallas W.S., Ballantine S.P., Delves C.J. FEMS Microbiol. Lett. 134:165-169(1995) [PubMed: 8586264] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U40768 Genomic DNA. Translation: AAC43582.1.
3D structure databases
HSSP	HSSP built from PDB template 1J6N based on UniProtKB Q9WZD3.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.47. 1190.
Family and domain databases
InterPro	IPR001216. Cys_synth_BS. IPR001926. PyrdxlP-dep_enz_bsu. [Graphical view]
Pfam	PF00291. PALP. 1 hit. [Graphical view]
PROSITE	PS00901. CYS_SYNTHASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYSK_STAHA

Accession

Primary (citable) accession number: Q59918

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 5, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)