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Reviewed, UniProtKB/Swiss-Prot Q59918 (CYSK_STAHA)

Last modified May 5, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cysteine synthase
      Short name=CSase
    EC=2.5.1.47
Alternative name(s):
    O-acetylserine sulfhydrylase
    O-acetylserine (thiol)-lyase
      Short name=OAS-TL
Gene names
Name: cysK
OrganismStaphylococcus haemolyticus
Taxonomic identifier1283 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length155 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

O(3)-acetyl-L-serine + H2S = L-cysteine + acetate.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cysteine synthase/cystathionine beta-synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 155›155Cysteine synthase
PRO_0000167103

Regions

Region25 – 295Pyridoxal phosphate binding By similarity

Sites

Binding site1131Pyridoxal phosphate By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q59918-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 609CF880E5826BBA

FASTA15516,121
        10         20         30         40         50         60 
ELTTGPEIVE QFEGKQIDAF LAGVGTGGTL SGAGKVLKEK YPNIEIVAIE PEASPVLSGG 

        70         80         90        100        110        120 
EPGPHKLQGL GAGFVPDTLN TDIYDSIIQV GNDIAMETSR RVAKEEGILA GISSGAAIHA 

       130        140        150 
AIQKAKELGK GKTVLTVLPS NGERYLSTPL YSFDD 

« Hide

References

[1]"Functional cloning of the dihydropteroate synthase gene of Staphylococcus haemolyticus."
Kellam P., Dallas W.S., Ballantine S.P., Delves C.J.
FEMS Microbiol. Lett. 134:165-169(1995) [PubMed: 8586264] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

U40768 Genomic DNA. Translation: AAC43582.1.

3D structure databases

HSSPHSSP built from PDB template 1J6N based on UniProtKB Q9WZD3.
ModBaseSearch...

Enzyme and pathway databases

BRENDA2.5.1.47. 1190.

Family and domain databases

InterProIPR001216. Cys_synth_BS.
IPR001926. PyrdxlP-dep_enz_bsu.
[Graphical view]
PfamPF00291. PALP. 1 hit.
[Graphical view]
PROSITEPS00901. CYS_SYNTHASE. Partial match.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYSK_STAHA
AccessionPrimary (citable) accession number: Q59918
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 5, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents