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Protein

RNA polymerase sigma factor SigA

Gene

hrdB

Organism
Streptomyces griseus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.SAAS annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi471 – 49020H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Sigma factorUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Gene namesi
Name:hrdBImported
Synonyms:sigAUniRule annotation
OrganismiStreptomyces griseusImported
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ59913.
SMRiQ59913. Positions 259-344, 437-509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini301 – 31414RNA_pol_sigma70InterPro annotationAdd
BLAST
Domaini470 – 49627RNA_pol_sigma70InterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni277 – 34771Sigma-70 factor domain-2UniRule annotationAdd
BLAST
Regioni356 – 43277Sigma-70 factor domain-3UniRule annotationAdd
BLAST
Regioni445 – 49854Sigma-70 factor domain-4UniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi301 – 3044Interaction with polymerase core subunit RpoCUniRule annotation

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00963. Sigma70_RpoD_SigA. 1 hit.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR028630. Sigma70_RpoD.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02393. RpoD_Cterm. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59913-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASTSRTLP PEIAESQSVM ALIERGKADG QIAGDDVRRA FEADQIPATQ
60 70 80 90 100
WKNVLRSLNQ ILEEEGVTLM VSAAEPKRTR KSVAAKSPAK RTATTRTVAA
110 120 130 140 150
KAAPVKKSAP AAAPTDEESE APVKKAAAKK TTAKKTAKKA TAKKTAAKKT
160 170 180 190 200
AAKNVVDELL DDEAEEKPTT GKPGEEGAPE GTGGESQGFV LSDDDEDDAP
210 220 230 240 250
AQQVAAAGAT ADPVKDYLKQ IGKVPLLNAE QEVELAKRIE AGLFAEDKLA
260 270 280 290 300
NADKIAPKLK RELEIIAEDG RRAKNHLLEA NLRLVVSLAK RYTGRGMLFL
310 320 330 340 350
DLIQEGNLGL IRAVEKFDYT KGYKFSTYAT WWIRQAITRA MADQARTIRI
360 370 380 390 400
PVHMVEVINK LARVQRQMLQ DLGREPTPEE LAKELDMTPE KVIEVQKYGR
410 420 430 440 450
EPISLHTPLG EDGDSEFGDL IEDSEAVVPA DAVSFTLLQE QLHSVLDTLS
460 470 480 490 500
EREAGVVSMR FGLTDGQPKT LDEIGKVYGV TRERIRQIES KTMSKLRHPS
510
RSQVLRDYLD
Length:510
Mass (Da):55,795
Last modified:November 1, 1996 - v1
Checksum:i676630CE64BD7D45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75952 Genomic DNA. Translation: CAA53564.1.
PIRiS41307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75952 Genomic DNA. Translation: CAA53564.1.
PIRiS41307.

3D structure databases

ProteinModelPortaliQ59913.
SMRiQ59913. Positions 259-344, 437-509.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00963. Sigma70_RpoD_SigA. 1 hit.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR028630. Sigma70_RpoD.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02393. RpoD_Cterm. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ59913_STRGR
AccessioniPrimary (citable) accession number: Q59913
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.