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Q59838

- MDH_SALMU

UniProt

Q59838 - MDH_SALMU

Protein

Malate dehydrogenase

Gene

mdh

Organism
Salmonella muenchen
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei23 – 231NADBy similarity
    Binding sitei70 – 701SubstratePROSITE-ProRule annotation
    Binding sitei76 – 761SubstratePROSITE-ProRule annotation
    Binding sitei83 – 831NADBy similarity
    Binding sitei108 – 1081SubstratePROSITE-ProRule annotation
    Binding sitei142 – 1421SubstratePROSITE-ProRule annotation
    Active sitei166 – 1661Proton acceptorBy similarity
    Binding sitei216 – 2161NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi‹1 – 2›2NADBy similarity
    Nucleotide bindingi106 – 1083NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    OrganismiSalmonella muenchen
    Taxonomic identifieri596 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›283›283Malate dehydrogenasePRO_0000113321Add
    BLAST

    Proteomic databases

    PRIDEiQ59838.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ59838.
    SMRiQ59838. Positions 1-283.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59838-1 [UniParc]FASTAAdd to Basket

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    IGQALALLLK NQLPSGSELS LYDIAPVTPG VAVDLSHIPT AVKIKGFSGE    50
    DVTPALEGAD VVLISAGVAR KPGMDRSDLF NVNAGIVKNL VQQIAKTCPK 100
    ACVGIITNPV NTTVAIAAEV LKKAGVYDKN KLFGVTTLDI IRSNTFVAEL 150
    KGKLPTEVEV PVIGGHSGVT ILPLLSQIPG VSFTEQEAAE LTKRIQNAGT 200
    EVVEAKAGGG SATLSMGQAA ARFGLSLVRA LQGEKDVVEC AYVEGDGQYA 250
    RFFSQPLLLG KNGVEERKSI GTLSAFEQHS LDA 283
    Length:283
    Mass (Da):29,503
    Last modified:November 1, 1996 - v1
    Checksum:i2C2A4D3593671320
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei283 – 2831

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04762 Genomic DNA. Translation: AAC43750.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04762 Genomic DNA. Translation: AAC43750.1 .

    3D structure databases

    ProteinModelPortali Q59838.
    SMRi Q59838. Positions 1-283.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q59838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010097. Malate_DH_type1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica."
      Boyd E.F., Nelson K., Wang F.-S., Whittam T.S., Selander R.K.
      Proc. Natl. Acad. Sci. U.S.A. 91:1280-1284(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S4272.

    Entry informationi

    Entry nameiMDH_SALMU
    AccessioniPrimary (citable) accession number: Q59838
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3