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Q59838

- MDH_SALMU

UniProt

Q59838 - MDH_SALMU

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Salmonella muenchen
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 231NADBy similarity
Binding sitei70 – 701SubstratePROSITE-ProRule annotation
Binding sitei76 – 761SubstratePROSITE-ProRule annotation
Binding sitei83 – 831NADBy similarity
Binding sitei108 – 1081SubstratePROSITE-ProRule annotation
Binding sitei142 – 1421SubstratePROSITE-ProRule annotation
Active sitei166 – 1661Proton acceptorBy similarity
Binding sitei216 – 2161NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi‹1 – 2›2NADBy similarity
Nucleotide bindingi106 – 1083NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiSalmonella muenchen
Taxonomic identifieri596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›283›283Malate dehydrogenasePRO_0000113321Add
BLAST

Proteomic databases

PRIDEiQ59838.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59838.
SMRiQ59838. Positions 1-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59838-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IGQALALLLK NQLPSGSELS LYDIAPVTPG VAVDLSHIPT AVKIKGFSGE
60 70 80 90 100
DVTPALEGAD VVLISAGVAR KPGMDRSDLF NVNAGIVKNL VQQIAKTCPK
110 120 130 140 150
ACVGIITNPV NTTVAIAAEV LKKAGVYDKN KLFGVTTLDI IRSNTFVAEL
160 170 180 190 200
KGKLPTEVEV PVIGGHSGVT ILPLLSQIPG VSFTEQEAAE LTKRIQNAGT
210 220 230 240 250
EVVEAKAGGG SATLSMGQAA ARFGLSLVRA LQGEKDVVEC AYVEGDGQYA
260 270 280
RFFSQPLLLG KNGVEERKSI GTLSAFEQHS LDA
Length:283
Mass (Da):29,503
Last modified:November 1, 1996 - v1
Checksum:i2C2A4D3593671320
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei283 – 2831

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04762 Genomic DNA. Translation: AAC43750.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04762 Genomic DNA. Translation: AAC43750.1 .

3D structure databases

ProteinModelPortali Q59838.
SMRi Q59838. Positions 1-283.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q59838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica."
    Boyd E.F., Nelson K., Wang F.-S., Whittam T.S., Selander R.K.
    Proc. Natl. Acad. Sci. U.S.A. 91:1280-1284(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S4272.

Entry informationi

Entry nameiMDH_SALMU
AccessioniPrimary (citable) accession number: Q59838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3