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Q59838

- MDH_SALMU

UniProt

Q59838 - MDH_SALMU

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Protein
Malate dehydrogenase
Gene
mdh
Organism
Salmonella muenchen
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 231NAD By similarity
Binding sitei70 – 701Substrate By similarity
Binding sitei76 – 761Substrate By similarity
Binding sitei83 – 831NAD By similarity
Binding sitei108 – 1081Substrate By similarity
Binding sitei142 – 1421Substrate By similarity
Active sitei166 – 1661Proton acceptor By similarity
Binding sitei216 – 2161NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi‹1 – 2›2NAD By similarity
Nucleotide bindingi106 – 1083NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiSalmonella muenchen
Taxonomic identifieri596 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›283›283Malate dehydrogenase
PRO_0000113321Add
BLAST

Proteomic databases

PRIDEiQ59838.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ59838.
SMRiQ59838. Positions 1-283.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59838-1 [UniParc]FASTAAdd to Basket

« Hide

IGQALALLLK NQLPSGSELS LYDIAPVTPG VAVDLSHIPT AVKIKGFSGE    50
DVTPALEGAD VVLISAGVAR KPGMDRSDLF NVNAGIVKNL VQQIAKTCPK 100
ACVGIITNPV NTTVAIAAEV LKKAGVYDKN KLFGVTTLDI IRSNTFVAEL 150
KGKLPTEVEV PVIGGHSGVT ILPLLSQIPG VSFTEQEAAE LTKRIQNAGT 200
EVVEAKAGGG SATLSMGQAA ARFGLSLVRA LQGEKDVVEC AYVEGDGQYA 250
RFFSQPLLLG KNGVEERKSI GTLSAFEQHS LDA 283
Length:283
Mass (Da):29,503
Last modified:November 1, 1996 - v1
Checksum:i2C2A4D3593671320
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei283 – 2831

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04762 Genomic DNA. Translation: AAC43750.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04762 Genomic DNA. Translation: AAC43750.1 .

3D structure databases

ProteinModelPortali Q59838.
SMRi Q59838. Positions 1-283.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q59838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica."
    Boyd E.F., Nelson K., Wang F.-S., Whittam T.S., Selander R.K.
    Proc. Natl. Acad. Sci. U.S.A. 91:1280-1284(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S4272.

Entry informationi

Entry nameiMDH_SALMU
AccessioniPrimary (citable) accession number: Q59838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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