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Q59838 (MDH_SALMU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
OrganismSalmonella muenchen
Taxonomic identifier596 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length283 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›283›283Malate dehydrogenase
PRO_0000113321

Regions

Nucleotide binding‹1 – 2›2NAD By similarity
Nucleotide binding106 – 1083NAD By similarity

Sites

Active site1661Proton acceptor By similarity
Binding site231NAD By similarity
Binding site701Substrate By similarity
Binding site761Substrate By similarity
Binding site831NAD By similarity
Binding site1081Substrate By similarity
Binding site1421Substrate By similarity
Binding site2161NAD By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2831

Sequences

Sequence LengthMass (Da)Tools
Q59838 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 2C2A4D3593671320

FASTA28329,503
        10         20         30         40         50         60 
IGQALALLLK NQLPSGSELS LYDIAPVTPG VAVDLSHIPT AVKIKGFSGE DVTPALEGAD 

        70         80         90        100        110        120 
VVLISAGVAR KPGMDRSDLF NVNAGIVKNL VQQIAKTCPK ACVGIITNPV NTTVAIAAEV 

       130        140        150        160        170        180 
LKKAGVYDKN KLFGVTTLDI IRSNTFVAEL KGKLPTEVEV PVIGGHSGVT ILPLLSQIPG 

       190        200        210        220        230        240 
VSFTEQEAAE LTKRIQNAGT EVVEAKAGGG SATLSMGQAA ARFGLSLVRA LQGEKDVVEC 

       250        260        270        280 
AYVEGDGQYA RFFSQPLLLG KNGVEERKSI GTLSAFEQHS LDA 

« Hide

References

[1]"Molecular genetic basis of allelic polymorphism in malate dehydrogenase (mdh) in natural populations of Escherichia coli and Salmonella enterica."
Boyd E.F., Nelson K., Wang F.-S., Whittam T.S., Selander R.K.
Proc. Natl. Acad. Sci. U.S.A. 91:1280-1284(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S4272.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U04762 Genomic DNA. Translation: AAC43750.1.

3D structure databases

ProteinModelPortalQ59838.
SMRQ59838. Positions 1-283.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ59838.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_SALMU
AccessionPrimary (citable) accession number: Q59838
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1996
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families