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Q59833

- GLGB1_STRCO

UniProt

Q59833 - GLGB1_STRCO

Protein

1,4-alpha-glucan branching enzyme GlgB 1

Gene

glgB1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.By similarity

    Catalytic activityi

    Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei457 – 4571NucleophileBy similarity
    Active sitei510 – 5101Proton donorBy similarity

    GO - Molecular functioni

    1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-HAMAP
    2. cation binding Source: InterPro
    3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. glycogen biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiCBM48. Carbohydrate-Binding Module Family 48.
    GH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1,4-alpha-glucan branching enzyme GlgB 1 (EC:2.4.1.18)
    Alternative name(s):
    1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase 1
    Alpha-(1->4)-glucan branching enzyme 1
    Glycogen branching enzyme 1
    Short name:
    BE 1
    Gene namesi
    Name:glgB1
    Synonyms:glgBI
    Ordered Locus Names:SCO5440
    ORF Names:SC6A11.16c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7747741,4-alpha-glucan branching enzyme GlgB 1PRO_0000188749Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi100226.SCO5440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59833.
    SMRiQ59833. Positions 173-764.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0296.
    HOGENOMiHOG000283037.
    KOiK00700.
    OMAiISEGRHE.
    OrthoDBiEOG6JX7GT.
    PhylomeDBiQ59833.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPiMF_00685. GlgB.
    InterProiIPR006048. A-amylase_b_C.
    IPR006407. GlgB.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR004193. Glyco_hydro_13_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF02806. Alpha-amylase_C. 1 hit.
    PF02922. CBM_48. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000463. GlgB. 1 hit.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF81296. SSF81296. 1 hit.
    TIGRFAMsiTIGR01515. branching_enzym. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59833-1 [UniParc]FASTAAdd to Basket

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    MTPRPSSSGP DPRKTTGKKP AGKTPTGKKP AKAAKKKAPR RTTASANASA    50
    TTSVSGAEVA VSPAPDAADR ERLLAGTHHD PHAVLGAHRV PGGVAFRVFR 100
    PYALAVTVLS GELRVGLHDD GDGFFSGLVP LKDVPAHRLL VAYEGTEQEV 150
    EDPYRFLPTL GELDLHLLGE GRHEQLWRAL GAHPTTHEGV AGTRFAVWAP 200
    NARGVRVAGG FNFWDGTGHP MRSLGSTGVW ELFLPGVGAG ELYKFEITRP 250
    DGSRTFRADP LARRTEVPPA TSSVVHASDY TWGDEEWLAH RADAPAHEAP 300
    MSVYEVHLPS WRPGLTYRQL AEQLPAYVAD LGFTHVELMP VAEHPFGGSW 350
    GYQVTGFYAP TARLGDPDDF KYLVDRLHRA GIGVLMDWVP AHFPRDDWAL 400
    AEFDGRPLYE HSDPLRAAHP DWGTLEFDFG RREVRNFLVA NAVYWCEEFH 450
    IDGLRVDAVA SMLYLDYSRE PGEWEPNEHG GRENLDAVAF LQEMNATLYR 500
    RVPGVVTVAE ESTAWDGVTR ATHHEGPSGF GGLGFGLKWN MGWMHDSLDY 550
    MSHEPVHRKH HHGEMTFSMV YAYSENYVLP ISHDEVVHGK RSLVSKMPGD 600
    WWQQRANERA YLGFMWAHPG KQLLFMGQEF AQGAEWSEAH GPDWWLLDPE 650
    YGASADHRGV RDLVRDLNTV YRATPALWRR DTHPSGFSWV VGDAAEDNVL 700
    AFLRLDADGT PLLAVSNFAP VVRSGYRLGV PDEVPAWHEV LNTDAARYGG 750
    GDVVNPDPVK PEPQGGTAAR RASG 774
    Length:774
    Mass (Da):85,451
    Last modified:August 15, 2003 - v2
    Checksum:i1D55555330F249BF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461T → R in CAA58314. (PubMed:8596463)Curated
    Sequence conflicti146 – 1461T → R in CAA04603. (PubMed:8596463)Curated
    Sequence conflicti766 – 7749GTAARRASG → WHGRPASIRLTLPPLATVWL RPA in CAA58314. (PubMed:8596463)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83397 Genomic DNA. Translation: CAA58314.1.
    AL939123 Genomic DNA. Translation: CAB72416.1.
    AJ001205 Genomic DNA. Translation: CAA04603.1.
    PIRiS70079.
    RefSeqiNP_629578.1. NC_003888.3.
    WP_011030247.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB72416; CAB72416; CAB72416.
    GeneIDi1100880.
    KEGGisco:SCO5440.
    PATRICi23740730. VBIStrCoe124346_5521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83397 Genomic DNA. Translation: CAA58314.1 .
    AL939123 Genomic DNA. Translation: CAB72416.1 .
    AJ001205 Genomic DNA. Translation: CAA04603.1 .
    PIRi S70079.
    RefSeqi NP_629578.1. NC_003888.3.
    WP_011030247.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q59833.
    SMRi Q59833. Positions 173-764.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO5440.

    Protein family/group databases

    CAZyi CBM48. Carbohydrate-Binding Module Family 48.
    GH13. Glycoside Hydrolase Family 13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB72416 ; CAB72416 ; CAB72416 .
    GeneIDi 1100880.
    KEGGi sco:SCO5440.
    PATRICi 23740730. VBIStrCoe124346_5521.

    Phylogenomic databases

    eggNOGi COG0296.
    HOGENOMi HOG000283037.
    KOi K00700.
    OMAi ISEGRHE.
    OrthoDBi EOG6JX7GT.
    PhylomeDBi Q59833.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPi MF_00685. GlgB.
    InterProi IPR006048. A-amylase_b_C.
    IPR006407. GlgB.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR004193. Glyco_hydro_13_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    PF02806. Alpha-amylase_C. 1 hit.
    PF02922. CBM_48. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000463. GlgB. 1 hit.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF81296. SSF81296. 1 hit.
    TIGRFAMsi TIGR01515. branching_enzym. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Tissue-specific glycogen branching isoenzymes in a multicellular prokaryote, Streptomyces coelicolor A3(2)."
      Bruton C.J., Plaskitt K.A., Chater K.F.
      Mol. Microbiol. 18:89-99(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A3(2) / NRRL B-16638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.
    3. "Duplicated gene clusters reveal a possible 'carbon relay' during aerial mycelium development in Streptomyces coelicolor A3(2)."
      Schneider D., Bruton C.J., Chater K.F.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217.
      Strain: A3(2) / NRRL B-16638.

    Entry informationi

    Entry nameiGLGB1_STRCO
    AccessioniPrimary (citable) accession number: Q59833
    Secondary accession number(s): Q9L1K4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3