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Q59833

- GLGB1_STRCO

UniProt

Q59833 - GLGB1_STRCO

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Protein

1,4-alpha-glucan branching enzyme GlgB 1

Gene

glgB1

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.By similarity

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei457 – 4571NucleophileBy similarity
Active sitei510 – 5101Proton donorBy similarity

GO - Molecular functioni

  1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-HAMAP
  2. cation binding Source: InterPro
  3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

Enzyme and pathway databases

UniPathwayiUPA00164.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-alpha-glucan branching enzyme GlgB 1 (EC:2.4.1.18)
Alternative name(s):
1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase 1
Alpha-(1->4)-glucan branching enzyme 1
Glycogen branching enzyme 1
Short name:
BE 1
Gene namesi
Name:glgB1
Synonyms:glgBI
Ordered Locus Names:SCO5440
ORF Names:SC6A11.16c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7747741,4-alpha-glucan branching enzyme GlgB 1PRO_0000188749Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi100226.SCO5440.

Structurei

3D structure databases

ProteinModelPortaliQ59833.
SMRiQ59833. Positions 173-764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0296.
HOGENOMiHOG000283037.
InParanoidiQ59833.
KOiK00700.
OMAiISEGRHE.
OrthoDBiEOG6JX7GT.
PhylomeDBiQ59833.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_00685. GlgB.
InterProiIPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view]
PIRSFiPIRSF000463. GlgB. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR01515. branching_enzym. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59833-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPRPSSSGP DPRKTTGKKP AGKTPTGKKP AKAAKKKAPR RTTASANASA
60 70 80 90 100
TTSVSGAEVA VSPAPDAADR ERLLAGTHHD PHAVLGAHRV PGGVAFRVFR
110 120 130 140 150
PYALAVTVLS GELRVGLHDD GDGFFSGLVP LKDVPAHRLL VAYEGTEQEV
160 170 180 190 200
EDPYRFLPTL GELDLHLLGE GRHEQLWRAL GAHPTTHEGV AGTRFAVWAP
210 220 230 240 250
NARGVRVAGG FNFWDGTGHP MRSLGSTGVW ELFLPGVGAG ELYKFEITRP
260 270 280 290 300
DGSRTFRADP LARRTEVPPA TSSVVHASDY TWGDEEWLAH RADAPAHEAP
310 320 330 340 350
MSVYEVHLPS WRPGLTYRQL AEQLPAYVAD LGFTHVELMP VAEHPFGGSW
360 370 380 390 400
GYQVTGFYAP TARLGDPDDF KYLVDRLHRA GIGVLMDWVP AHFPRDDWAL
410 420 430 440 450
AEFDGRPLYE HSDPLRAAHP DWGTLEFDFG RREVRNFLVA NAVYWCEEFH
460 470 480 490 500
IDGLRVDAVA SMLYLDYSRE PGEWEPNEHG GRENLDAVAF LQEMNATLYR
510 520 530 540 550
RVPGVVTVAE ESTAWDGVTR ATHHEGPSGF GGLGFGLKWN MGWMHDSLDY
560 570 580 590 600
MSHEPVHRKH HHGEMTFSMV YAYSENYVLP ISHDEVVHGK RSLVSKMPGD
610 620 630 640 650
WWQQRANERA YLGFMWAHPG KQLLFMGQEF AQGAEWSEAH GPDWWLLDPE
660 670 680 690 700
YGASADHRGV RDLVRDLNTV YRATPALWRR DTHPSGFSWV VGDAAEDNVL
710 720 730 740 750
AFLRLDADGT PLLAVSNFAP VVRSGYRLGV PDEVPAWHEV LNTDAARYGG
760 770
GDVVNPDPVK PEPQGGTAAR RASG
Length:774
Mass (Da):85,451
Last modified:August 15, 2003 - v2
Checksum:i1D55555330F249BF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1461T → R in CAA58314. (PubMed:8596463)Curated
Sequence conflicti146 – 1461T → R in CAA04603. (PubMed:8596463)Curated
Sequence conflicti766 – 7749GTAARRASG → WHGRPASIRLTLPPLATVWL RPA in CAA58314. (PubMed:8596463)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83397 Genomic DNA. Translation: CAA58314.1.
AL939123 Genomic DNA. Translation: CAB72416.1.
AJ001205 Genomic DNA. Translation: CAA04603.1.
PIRiS70079.
RefSeqiNP_629578.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB72416; CAB72416; CAB72416.
GeneIDi1100880.
KEGGisco:SCO5440.
PATRICi23740730. VBIStrCoe124346_5521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83397 Genomic DNA. Translation: CAA58314.1 .
AL939123 Genomic DNA. Translation: CAB72416.1 .
AJ001205 Genomic DNA. Translation: CAA04603.1 .
PIRi S70079.
RefSeqi NP_629578.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q59833.
SMRi Q59833. Positions 173-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO5440.

Protein family/group databases

CAZyi CBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB72416 ; CAB72416 ; CAB72416 .
GeneIDi 1100880.
KEGGi sco:SCO5440.
PATRICi 23740730. VBIStrCoe124346_5521.

Phylogenomic databases

eggNOGi COG0296.
HOGENOMi HOG000283037.
InParanoidi Q59833.
KOi K00700.
OMAi ISEGRHE.
OrthoDBi EOG6JX7GT.
PhylomeDBi Q59833.

Enzyme and pathway databases

UniPathwayi UPA00164 .

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_00685. GlgB.
InterProi IPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view ]
PIRSFi PIRSF000463. GlgB. 1 hit.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsi TIGR01515. branching_enzym. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific glycogen branching isoenzymes in a multicellular prokaryote, Streptomyces coelicolor A3(2)."
    Bruton C.J., Plaskitt K.A., Chater K.F.
    Mol. Microbiol. 18:89-99(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.
  3. "Duplicated gene clusters reveal a possible 'carbon relay' during aerial mycelium development in Streptomyces coelicolor A3(2)."
    Schneider D., Bruton C.J., Chater K.F.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-217.
    Strain: A3(2) / NRRL B-16638.

Entry informationi

Entry nameiGLGB1_STRCO
AccessioniPrimary (citable) accession number: Q59833
Secondary accession number(s): Q9L1K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: August 15, 2003
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3