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Q59832

- GLGB2_STRCO

UniProt

Q59832 - GLGB2_STRCO

Protein

1,4-alpha-glucan branching enzyme GlgB 2

Gene

glgB2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (15 Aug 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.By similarity

    Catalytic activityi

    Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei421 – 4211NucleophileBy similarity
    Active sitei474 – 4741Proton donorBy similarity

    GO - Molecular functioni

    1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-HAMAP
    2. cation binding Source: InterPro
    3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. glycogen biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiCBM48. Carbohydrate-Binding Module Family 48.
    GH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1,4-alpha-glucan branching enzyme GlgB 2 (EC:2.4.1.18)
    Alternative name(s):
    1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase 2
    Alpha-(1->4)-glucan branching enzyme 2
    Glycogen branching enzyme 2
    Short name:
    BE 2
    Gene namesi
    Name:glgB2
    Synonyms:glgBII
    Ordered Locus Names:SCO7332
    ORF Names:SC4G10.11c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7417411,4-alpha-glucan branching enzyme GlgB 2PRO_0000188750Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi100226.SCO7332.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59832.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0296.
    HOGENOMiHOG000283037.
    KOiK00700.
    OMAiHENIENP.
    OrthoDBiEOG6JX7GT.
    PhylomeDBiQ59832.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPiMF_00685. GlgB.
    InterProiIPR006048. A-amylase_b_C.
    IPR006407. GlgB.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR004193. Glyco_hydro_13_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    PF02806. Alpha-amylase_C. 1 hit.
    PF02922. CBM_48. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000463. GlgB. 1 hit.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF81296. SSF81296. 1 hit.
    TIGRFAMsiTIGR01515. branching_enzym. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59832-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRDTSIPE PSGPVPPAPG ACATAPPLDP TDRGRLLAGA HHDPHSLLGA    50
    HPVPGGIAFR VLRPFAREVG VVVDGERHTL ASEEDGLFSG VLPLAGIPSY 100
    TLVVAYEQGE TQETHDPYRF LPALGELDLH LIGEGRHEQL WQALGAEPMT 150
    HEGVTGTRFT VWAPNAQGVR VATDFTHWDG TAFPMRSLGS SGVWELFLPG 200
    VGEGTRYKFE IHSRYGHRFL KADPMARAAE EPPNTASVVT ASRYEWGDAQ 250
    WMRTRADTPV HEAPFSVYEV HLPSWRPGLT YRELAEELPA YVKDLGFTHV 300
    ELMPVAEHPY GPSWGYQVTG FYAPTARLGS PDDFRFLVDA LHRAGIGVIM 350
    DWVPAHFPKD DWALGRFDGD PLYEPGDSRR AEHPDWGTYT FDFARTEVRN 400
    FLVANAVYWC EEFHIDGLRV DAVASMLYLD YSRDSGQWEP NQYGGREDLA 450
    AMAFLQEMNA TVYRRCPGVV TIAEESTAWG GVTRPTDTGG LGFGLKWNMG 500
    WMHDSLEYVA HEPVHRRYHH HEMTFSMVYA YSENYVLPIS HDEVVHGKQA 550
    LVSKMPGDWW QRRANVRAYL GFMWAHPGKQ LLFMGQEFAQ GAEWSEKQGP 600
    EWWLLDEGYH SAGDHRGVQD LVRELNTRYT RTPALWQRDT DPAGFRWVSV 650
    DAAEDNVFAF LRYGTDGTPL LAVSNFSPVV RHEYGLAVGD EAVAWQEVLN 700
    TDAEEYGGGG VGNPDPVKPE DGSIRITLPP LATVWLMPYA L 741
    Length:741
    Mass (Da):82,776
    Last modified:August 15, 2003 - v2
    Checksum:i5FB7A44120677759
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti561 – 5611Q → H in CAA52109. (PubMed:8596463)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73903 Genomic DNA. Translation: CAA52109.1.
    AL939131 Genomic DNA. Translation: CAB92878.1.
    PIRiS70078. S34218.
    RefSeqiNP_631386.1. NC_003888.3.
    WP_011031592.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB92878; CAB92878; CAB92878.
    GeneIDi1102770.
    KEGGisco:SCO7332.
    PATRICi23744587. VBIStrCoe124346_7436.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X73903 Genomic DNA. Translation: CAA52109.1 .
    AL939131 Genomic DNA. Translation: CAB92878.1 .
    PIRi S70078. S34218.
    RefSeqi NP_631386.1. NC_003888.3.
    WP_011031592.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q59832.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO7332.

    Protein family/group databases

    CAZyi CBM48. Carbohydrate-Binding Module Family 48.
    GH13. Glycoside Hydrolase Family 13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB92878 ; CAB92878 ; CAB92878 .
    GeneIDi 1102770.
    KEGGi sco:SCO7332.
    PATRICi 23744587. VBIStrCoe124346_7436.

    Phylogenomic databases

    eggNOGi COG0296.
    HOGENOMi HOG000283037.
    KOi K00700.
    OMAi HENIENP.
    OrthoDBi EOG6JX7GT.
    PhylomeDBi Q59832.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPi MF_00685. GlgB.
    InterProi IPR006048. A-amylase_b_C.
    IPR006407. GlgB.
    IPR015902. Glyco_hydro_13.
    IPR013780. Glyco_hydro_13_b.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR004193. Glyco_hydro_13_N.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    PF02806. Alpha-amylase_C. 1 hit.
    PF02922. CBM_48. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000463. GlgB. 1 hit.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF81296. SSF81296. 1 hit.
    TIGRFAMsi TIGR01515. branching_enzym. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Tissue-specific glycogen branching isoenzymes in a multicellular prokaryote, Streptomyces coelicolor A3(2)."
      Bruton C.J., Plaskitt K.A., Chater K.F.
      Mol. Microbiol. 18:89-99(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A3(2) / NRRL B-16638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiGLGB2_STRCO
    AccessioniPrimary (citable) accession number: Q59832
    Secondary accession number(s): Q9KY06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: August 15, 2003
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3