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Protein

Cytochrome P450 105A3

Gene

cyp105A3

Organism
Streptomyces carbophilus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydroxylation of sodium ML-236B carboxylate to pravastatin.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi359Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 105A3 (EC:1.14.-.-)
Alternative name(s):
Cytochrome P450 sca-2
Short name:
CYT P-450sca-2
Gene namesi
Name:cyp105A3
OrganismiStreptomyces carbophilus
Taxonomic identifieri44059 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000522142 – 410Cytochrome P450 105A3Add BLAST409

Expressioni

Inductioni

By sodium ML-236B carboxylate.1 Publication

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliQ59831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEMTEKATT FLTSQEAPAF PADRTCPYQL PTAYSRLRDE PDALRPVTLY
60 70 80 90 100
DGRRAWVVTK HEAARRLLAD PRLSSDRLHA DFPATSPRFK AFRQGSPAFI
110 120 130 140 150
GMDPPEHGTR RRMTISEFTV KRIKGMRPDV ERIVHGFIDD MLAAGPTADL
160 170 180 190 200
VSQFALPVPS MVICHMLGVP YADHEFFQDA SKRLVQAVDA DSAVAARDDF
210 220 230 240 250
ERYLDGLITK LESEPGTGLL GKLVTHQLAD GEIDRAELIS TALLLLVAGH
260 270 280 290 300
ETTASMTSLS VITLLEHPDQ HAALRADPSL VPGAVEELLR VLAIADIAGG
310 320 330 340 350
RIATADIEID GQLIRAGEGV IVTNSIANRD SSVFENPDRL DVHRSARHHL
360 370 380 390 400
SFGYGVHQCL GQNLARLELE VILTVLFDRI PTLRLAVPVE QLTLRPGTTI
410
QGVNELPVTW
Length:410
Mass (Da):45,049
Last modified:January 23, 2007 - v3
Checksum:i23E8735606942264
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30815 Genomic DNA. Translation: BAA06492.1.
PIRiJC4287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30815 Genomic DNA. Translation: BAA06492.1.
PIRiJC4287.

3D structure databases

ProteinModelPortaliQ59831.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPS2_STRCC
AccessioniPrimary (citable) accession number: Q59831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 23, 2007
Last modified: October 5, 2016
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.