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Protein

RNA polymerase sigma factor SigA

Gene

hrdC

Organism
Kitasatospora aureofaciens (Streptomyces aureofaciens)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi489 – 508H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, Sigma factorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Gene namesi
Name:hrdCImported
Synonyms:sigAUniRule annotation
OrganismiKitasatospora aureofaciens (Streptomyces aureofaciens)Imported
Taxonomic identifieri1894 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeKitasatospora

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ59814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini319 – 332RNA_pol_sigma70InterPro annotationAdd BLAST14
Domaini488 – 514RNA_pol_sigma70InterPro annotationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni295 – 365Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni374 – 450Sigma-70 factor domain-3UniRule annotationAdd BLAST77
Regioni463 – 516Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi319 – 322Interaction with polymerase core subunit RpoCUniRule annotation4

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00963. Sigma70_RpoD_SigA. 1 hit.
InterProiView protein in InterPro
IPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR028630. Sigma70_RpoD.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02393. RpoD_Cterm. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiView protein in PROSITE
PS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSPSRTFP PEIAESEALV ALVERGREQG HINGDDVRQA FEAGRIPVDQ
60 70 80 90 100
WKRVLRSLNQ VLDEEGVALH VSAAPATKAA AKKPRKAAAA PARTVTKKAA
110 120 130 140 150
APPRPIGARK TSAAAPAAAA AISAPSAAAT GDEATAEAAA EPKKRTVKKT
160 170 180 190 200
AAKKATATKK TAATKKAGAK DGDDAENPAV EGEDWAVEDL ADEAEEETPK
210 220 230 240 250
AGGTQGFVLS DDDEDDAPAQ TVMVAGATAD PVKDYLKLIG KVPLLNAEQE
260 270 280 290 300
VELAKRIEAG LFSEYKLEEE EDHKPAFKRE LEILVEDGRR AKNHLLEANL
310 320 330 340 350
RLVVSLAKRY TGRGMLFLDL IQEGNVGLIR AVEKFDYTKG FKFSTYATWW
360 370 380 390 400
IRQAITRAMA DQSRTIRIPV HMVEIINKLA RVQRQMLQDL GREPTPEELG
410 420 430 440 450
KELDMTPEKV IEVQKYGREP ISLHTPLGEE GDSEFGDLIE DSEAVVPADA
460 470 480 490 500
VSFTFLQEQL QSILGTLSER EAGVVSMRYG LNDGQPKTLD EIGRVYGVTR
510 520
ERIRQIESKT MSKLRHPSRS QVLRGYLD
Length:528
Mass (Da):57,598
Last modified:November 1, 1996 - v1
Checksum:iA22B76FFE5C065D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90412 Genomic DNA. Translation: AAA26764.1.
PIRiJN0445.

Similar proteinsi

Entry informationi

Entry nameiQ59814_KITAU
AccessioniPrimary (citable) accession number: Q59814
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)