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Protein

Hyaluronate lyase

Gene

hysA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciSAUR93061:G1G5Y-2329-MONOMER

Protein family/group databases

CAZyiPL8 Polysaccharide Lyase Family 8

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronate lyase (EC:4.2.2.1)
Alternative name(s):
Hyaluronidase
Short name:
HYase
Gene namesi
Name:hysA
Ordered Locus Names:SAOUHSC_02463
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000008816 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 40Sequence analysisAdd BLAST40
ChainiPRO_000002493141 – 807Hyaluronate lyaseAdd BLAST767

Proteomic databases

PRIDEiQ59801

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02463

Structurei

3D structure databases

ProteinModelPortaliQ59801
SMRiQ59801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polysaccharide lyase 8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106AM8 Bacteria
ENOG410XTFC LUCA
HOGENOMiHOG000280193
KOiK01727
OMAiRYYQDET

Family and domain databases

Gene3Di1.50.10.100, 1 hit
2.60.220.10, 1 hit
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR008929 Chondroitin_lyas
IPR011013 Gal_mutarotase_sf_dom
IPR014718 GH-type_carb-bd
IPR038970 Lyase_8
IPR011071 Lyase_8-like_C
IPR012970 Lyase_8_alpha_N
IPR004103 Lyase_8_C
IPR003159 Lyase_8_central_dom
PANTHERiPTHR38481 PTHR38481, 1 hit
PfamiView protein in Pfam
PF02278 Lyase_8, 1 hit
PF02884 Lyase_8_C, 1 hit
PF08124 Lyase_8_N, 1 hit
SUPFAMiSSF48230 SSF48230, 1 hit
SSF49863 SSF49863, 1 hit
SSF74650 SSF74650, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYRIKKWQK LSTITLLMAG VITLNGGEFR SVDKHQIAVA DTNVQTPDYE
60 70 80 90 100
KLRNTWLDVN YGYDKYDENN PDMKKKFDAT EKEATNLLKE MKTESGRKYL
110 120 130 140 150
WSGAETLETN SSHMTRTYRN IEKIAEAMRN PKTTLNTDEN KKKVKDALEW
160 170 180 190 200
LHKNAYGKEP DKKVKELSEN FTKTTGKNTN LNWWDYEIGT PKSLTNTLIL
210 220 230 240 250
LNDQFSNEEK KKFTAPIKTF APDSDKILSS VGKAELAKGG NLVDISKVKL
260 270 280 290 300
LECIIEEDKD MMKKSIDSFN KVFTYVQDSA TGKERNGFYK DGSYIDHQDV
310 320 330 340 350
PYTGAYGVVL LEGISQMMPM IKETPFNDKT QNDTTLKSWI DDGFMPLIYK
360 370 380 390 400
GEMMDLSRGR AISRENETSH SASATVMKSL LRLSDAMDDS TKAKYKKIVK
410 420 430 440 450
SSVESDSSYK QNDYLNSYSD IDKMKSLMTD NSISKNGLTQ QLKIYNDMDR
460 470 480 490 500
VTYHNKDLDF AFGLSMTSKN VARYESINGE NLKGWHTGAG MSYLYNSDVK
510 520 530 540 550
HYHDNFWVTA DMKRLSGTTT LDNEILKDTD DKKSSKTFVG GTKVDDQHAS
560 570 580 590 600
IGMDFENQDK TLTAKKSYFI LNDKIVFLGT GIKSTDSSKN PVTTIENRKA
610 620 630 640 650
NGYTLYTDDK QTTNSDNQEN NSVFLESTDT KKNIGYHFLN KPKITVKKES
660 670 680 690 700
HTGKWKEINK SQKDTQKTDE YYEVTQKHSN SDNKYGYVLY PGLSKDVFKT
710 720 730 740 750
KKDEVTVVKQ EDDFHVVKDN ESVWAGVNYS NSTQTFDINN TKVEVKAKGM
760 770 780 790 800
FILKKKDDNT YECSFYNPES TNSASDIESK ISMTGYSITN KNTSTSNESG

VHFELTK
Length:807
Mass (Da):91,985
Last modified:November 1, 1996 - v1
Checksum:iFFE88EDC07418EB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21221 Genomic DNA Translation: AAA82984.1
CP000253 Genomic DNA Translation: ABD31483.1
RefSeqiWP_000222239.1, NC_007795.1
YP_500931.1, NC_007795.1

Genome annotation databases

EnsemblBacteriaiABD31483; ABD31483; SAOUHSC_02463
GeneIDi3919026
KEGGisao:SAOUHSC_02463
PATRICifig|93061.5.peg.2222

Similar proteinsi

Entry informationi

Entry nameiHYSA_STAA8
AccessioniPrimary (citable) accession number: Q59801
Secondary accession number(s): Q2FW54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health