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Q59801

- HYSA_STAA8

UniProt

Q59801 - HYSA_STAA8

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Protein

Hyaluronate lyase

Gene

hysA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. hyaluronate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciSAUR93061:GIWJ-2399-MONOMER.

Protein family/group databases

CAZyiPL8. Polysaccharide Lyase Family 8.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronate lyase (EC:4.2.2.1)
Alternative name(s):
Hyaluronidase
Short name:
HYase
Gene namesi
Name:hysA
Ordered Locus Names:SAOUHSC_02463
OrganismiStaphylococcus aureus (strain NCTC 8325)
Taxonomic identifieri93061 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000008816: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4040Sequence AnalysisAdd
BLAST
Chaini41 – 807767Hyaluronate lyasePRO_0000024931Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi93061.SAOUHSC_02463.

Structurei

3D structure databases

ProteinModelPortaliQ59801.
SMRiQ59801. Positions 49-778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polysaccharide lyase 8 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG04835.
HOGENOMiHOG000280193.
KOiK01727.
OMAiRYYQDET.
OrthoDBiEOG6GBM67.

Family and domain databases

Gene3Di1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProiIPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
[Graphical view]
PfamiPF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view]
SUPFAMiSSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59801 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTYRIKKWQK LSTITLLMAG VITLNGGEFR SVDKHQIAVA DTNVQTPDYE
60 70 80 90 100
KLRNTWLDVN YGYDKYDENN PDMKKKFDAT EKEATNLLKE MKTESGRKYL
110 120 130 140 150
WSGAETLETN SSHMTRTYRN IEKIAEAMRN PKTTLNTDEN KKKVKDALEW
160 170 180 190 200
LHKNAYGKEP DKKVKELSEN FTKTTGKNTN LNWWDYEIGT PKSLTNTLIL
210 220 230 240 250
LNDQFSNEEK KKFTAPIKTF APDSDKILSS VGKAELAKGG NLVDISKVKL
260 270 280 290 300
LECIIEEDKD MMKKSIDSFN KVFTYVQDSA TGKERNGFYK DGSYIDHQDV
310 320 330 340 350
PYTGAYGVVL LEGISQMMPM IKETPFNDKT QNDTTLKSWI DDGFMPLIYK
360 370 380 390 400
GEMMDLSRGR AISRENETSH SASATVMKSL LRLSDAMDDS TKAKYKKIVK
410 420 430 440 450
SSVESDSSYK QNDYLNSYSD IDKMKSLMTD NSISKNGLTQ QLKIYNDMDR
460 470 480 490 500
VTYHNKDLDF AFGLSMTSKN VARYESINGE NLKGWHTGAG MSYLYNSDVK
510 520 530 540 550
HYHDNFWVTA DMKRLSGTTT LDNEILKDTD DKKSSKTFVG GTKVDDQHAS
560 570 580 590 600
IGMDFENQDK TLTAKKSYFI LNDKIVFLGT GIKSTDSSKN PVTTIENRKA
610 620 630 640 650
NGYTLYTDDK QTTNSDNQEN NSVFLESTDT KKNIGYHFLN KPKITVKKES
660 670 680 690 700
HTGKWKEINK SQKDTQKTDE YYEVTQKHSN SDNKYGYVLY PGLSKDVFKT
710 720 730 740 750
KKDEVTVVKQ EDDFHVVKDN ESVWAGVNYS NSTQTFDINN TKVEVKAKGM
760 770 780 790 800
FILKKKDDNT YECSFYNPES TNSASDIESK ISMTGYSITN KNTSTSNESG

VHFELTK
Length:807
Mass (Da):91,985
Last modified:November 1, 1996 - v1
Checksum:iFFE88EDC07418EB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U21221 Genomic DNA. Translation: AAA82984.1.
CP000253 Genomic DNA. Translation: ABD31483.1.
RefSeqiWP_000222239.1. NC_007795.1.
YP_500931.1. NC_007795.1.

Genome annotation databases

EnsemblBacteriaiABD31483; ABD31483; SAOUHSC_02463.
GeneIDi3919026.
KEGGisao:SAOUHSC_02463.
PATRICi19582232. VBIStaAur99865_2222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U21221 Genomic DNA. Translation: AAA82984.1 .
CP000253 Genomic DNA. Translation: ABD31483.1 .
RefSeqi WP_000222239.1. NC_007795.1.
YP_500931.1. NC_007795.1.

3D structure databases

ProteinModelPortali Q59801.
SMRi Q59801. Positions 49-778.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 93061.SAOUHSC_02463.

Protein family/group databases

CAZyi PL8. Polysaccharide Lyase Family 8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD31483 ; ABD31483 ; SAOUHSC_02463 .
GeneIDi 3919026.
KEGGi sao:SAOUHSC_02463.
PATRICi 19582232. VBIStaAur99865_2222.

Phylogenomic databases

eggNOGi NOG04835.
HOGENOMi HOG000280193.
KOi K01727.
OMAi RYYQDET.
OrthoDBi EOG6GBM67.

Enzyme and pathway databases

BioCyci SAUR93061:GIWJ-2399-MONOMER.

Miscellaneous databases

PROi Q59801.

Family and domain databases

Gene3Di 1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProi IPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
[Graphical view ]
Pfami PF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view ]
SUPFAMi SSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, nucleotide sequence determination and expression of the Staphylococcus aureus hyaluronate lyase gene."
    Farrell A.M., Taylor D., Holland K.T.
    FEMS Microbiol. Lett. 130:81-85(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The Staphylococcus aureus NCTC 8325 genome."
    Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
    (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCTC 8325.

Entry informationi

Entry nameiHYSA_STAA8
AccessioniPrimary (citable) accession number: Q59801
Secondary accession number(s): Q2FW54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3