Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q59801 (HYSA_STAA8) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronate lyase

EC=4.2.2.1
Alternative name(s):
Hyaluronidase
Short name=HYase
Gene names
Name:hysA
Ordered Locus Names:SAOUHSC_02463
OrganismStaphylococcus aureus (strain NCTC 8325) [Reference proteome] [HAMAP]
Taxonomic identifier93061 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length807 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

Subcellular location

Secreted.

Sequence similarities

Belongs to the polysaccharide lyase 8 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

hyaluronate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4040 Potential
Chain41 – 807767Hyaluronate lyase
PRO_0000024931

Sequences

Sequence LengthMass (Da)Tools
Q59801 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FFE88EDC07418EB4

FASTA80791,985
        10         20         30         40         50         60 
MTYRIKKWQK LSTITLLMAG VITLNGGEFR SVDKHQIAVA DTNVQTPDYE KLRNTWLDVN 

        70         80         90        100        110        120 
YGYDKYDENN PDMKKKFDAT EKEATNLLKE MKTESGRKYL WSGAETLETN SSHMTRTYRN 

       130        140        150        160        170        180 
IEKIAEAMRN PKTTLNTDEN KKKVKDALEW LHKNAYGKEP DKKVKELSEN FTKTTGKNTN 

       190        200        210        220        230        240 
LNWWDYEIGT PKSLTNTLIL LNDQFSNEEK KKFTAPIKTF APDSDKILSS VGKAELAKGG 

       250        260        270        280        290        300 
NLVDISKVKL LECIIEEDKD MMKKSIDSFN KVFTYVQDSA TGKERNGFYK DGSYIDHQDV 

       310        320        330        340        350        360 
PYTGAYGVVL LEGISQMMPM IKETPFNDKT QNDTTLKSWI DDGFMPLIYK GEMMDLSRGR 

       370        380        390        400        410        420 
AISRENETSH SASATVMKSL LRLSDAMDDS TKAKYKKIVK SSVESDSSYK QNDYLNSYSD 

       430        440        450        460        470        480 
IDKMKSLMTD NSISKNGLTQ QLKIYNDMDR VTYHNKDLDF AFGLSMTSKN VARYESINGE 

       490        500        510        520        530        540 
NLKGWHTGAG MSYLYNSDVK HYHDNFWVTA DMKRLSGTTT LDNEILKDTD DKKSSKTFVG 

       550        560        570        580        590        600 
GTKVDDQHAS IGMDFENQDK TLTAKKSYFI LNDKIVFLGT GIKSTDSSKN PVTTIENRKA 

       610        620        630        640        650        660 
NGYTLYTDDK QTTNSDNQEN NSVFLESTDT KKNIGYHFLN KPKITVKKES HTGKWKEINK 

       670        680        690        700        710        720 
SQKDTQKTDE YYEVTQKHSN SDNKYGYVLY PGLSKDVFKT KKDEVTVVKQ EDDFHVVKDN 

       730        740        750        760        770        780 
ESVWAGVNYS NSTQTFDINN TKVEVKAKGM FILKKKDDNT YECSFYNPES TNSASDIESK 

       790        800 
ISMTGYSITN KNTSTSNESG VHFELTK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, nucleotide sequence determination and expression of the Staphylococcus aureus hyaluronate lyase gene."
Farrell A.M., Taylor D., Holland K.T.
FEMS Microbiol. Lett. 130:81-85(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The Staphylococcus aureus NCTC8325 genome."
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCTC 8325.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U21221 Genomic DNA. Translation: AAA82984.1.
CP000253 Genomic DNA. Translation: ABD31483.1.
RefSeqYP_500931.1. NC_007795.1.

3D structure databases

ProteinModelPortalQ59801.
SMRQ59801. Positions 49-778.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING93061.SAOUHSC_02463.

Protein family/group databases

CAZyPL8. Polysaccharide Lyase Family 8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD31483; ABD31483; SAOUHSC_02463.
GeneID3919026.
KEGGsao:SAOUHSC_02463.
PATRIC19582232. VBIStaAur99865_2222.

Phylogenomic databases

eggNOGNOG04835.
HOGENOMHOG000280193.
KOK01727.
OMARYYQDET.
OrthoDBEOG6GBM67.
ProtClustDBCLSK885824.

Enzyme and pathway databases

BioCycSAUR93061:GIWJ-2399-MONOMER.

Family and domain databases

Gene3D1.50.10.100. 1 hit.
2.60.220.10. 1 hit.
2.70.98.10. 1 hit.
InterProIPR008929. Chondroitin_lyas.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR011071. Lyase_8-like_C.
IPR012970. Lyase_8_alpha_N.
IPR004103. Lyase_8_C.
IPR003159. Lyase_8_central_dom.
IPR012329. Lyase_8_N.
[Graphical view]
PfamPF02278. Lyase_8. 1 hit.
PF02884. Lyase_8_C. 1 hit.
PF08124. Lyase_8_N. 1 hit.
[Graphical view]
SUPFAMSSF48230. SSF48230. 1 hit.
SSF49863. SSF49863. 1 hit.
SSF74650. SSF74650. 1 hit.
ProtoNetSearch...

Other

PROQ59801.

Entry information

Entry nameHYSA_STAA8
AccessionPrimary (citable) accession number: Q59801
Secondary accession number(s): Q2FW54
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 13, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families