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Q59801

- HYSA_STAA8

UniProt

Q59801 - HYSA_STAA8

Protein

Hyaluronate lyase

Gene

hysA

Organism
Staphylococcus aureus (strain NCTC 8325)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cleaves hyaluronate chains at a beta-D-GalNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. hyaluronate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Enzyme and pathway databases

    BioCyciSAUR93061:GIWJ-2399-MONOMER.

    Protein family/group databases

    CAZyiPL8. Polysaccharide Lyase Family 8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronate lyase (EC:4.2.2.1)
    Alternative name(s):
    Hyaluronidase
    Short name:
    HYase
    Gene namesi
    Name:hysA
    Ordered Locus Names:SAOUHSC_02463
    OrganismiStaphylococcus aureus (strain NCTC 8325)
    Taxonomic identifieri93061 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000008816: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4040Sequence AnalysisAdd
    BLAST
    Chaini41 – 807767Hyaluronate lyasePRO_0000024931Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi93061.SAOUHSC_02463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59801.
    SMRiQ59801. Positions 49-778.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polysaccharide lyase 8 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG04835.
    HOGENOMiHOG000280193.
    KOiK01727.
    OMAiRYYQDET.
    OrthoDBiEOG6GBM67.

    Family and domain databases

    Gene3Di1.50.10.100. 1 hit.
    2.60.220.10. 1 hit.
    2.70.98.10. 1 hit.
    InterProiIPR008929. Chondroitin_lyas.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR011071. Lyase_8-like_C.
    IPR012970. Lyase_8_alpha_N.
    IPR004103. Lyase_8_C.
    IPR003159. Lyase_8_central_dom.
    IPR012329. Lyase_8_N.
    [Graphical view]
    PfamiPF02278. Lyase_8. 1 hit.
    PF02884. Lyase_8_C. 1 hit.
    PF08124. Lyase_8_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48230. SSF48230. 1 hit.
    SSF49863. SSF49863. 1 hit.
    SSF74650. SSF74650. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q59801-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTYRIKKWQK LSTITLLMAG VITLNGGEFR SVDKHQIAVA DTNVQTPDYE    50
    KLRNTWLDVN YGYDKYDENN PDMKKKFDAT EKEATNLLKE MKTESGRKYL 100
    WSGAETLETN SSHMTRTYRN IEKIAEAMRN PKTTLNTDEN KKKVKDALEW 150
    LHKNAYGKEP DKKVKELSEN FTKTTGKNTN LNWWDYEIGT PKSLTNTLIL 200
    LNDQFSNEEK KKFTAPIKTF APDSDKILSS VGKAELAKGG NLVDISKVKL 250
    LECIIEEDKD MMKKSIDSFN KVFTYVQDSA TGKERNGFYK DGSYIDHQDV 300
    PYTGAYGVVL LEGISQMMPM IKETPFNDKT QNDTTLKSWI DDGFMPLIYK 350
    GEMMDLSRGR AISRENETSH SASATVMKSL LRLSDAMDDS TKAKYKKIVK 400
    SSVESDSSYK QNDYLNSYSD IDKMKSLMTD NSISKNGLTQ QLKIYNDMDR 450
    VTYHNKDLDF AFGLSMTSKN VARYESINGE NLKGWHTGAG MSYLYNSDVK 500
    HYHDNFWVTA DMKRLSGTTT LDNEILKDTD DKKSSKTFVG GTKVDDQHAS 550
    IGMDFENQDK TLTAKKSYFI LNDKIVFLGT GIKSTDSSKN PVTTIENRKA 600
    NGYTLYTDDK QTTNSDNQEN NSVFLESTDT KKNIGYHFLN KPKITVKKES 650
    HTGKWKEINK SQKDTQKTDE YYEVTQKHSN SDNKYGYVLY PGLSKDVFKT 700
    KKDEVTVVKQ EDDFHVVKDN ESVWAGVNYS NSTQTFDINN TKVEVKAKGM 750
    FILKKKDDNT YECSFYNPES TNSASDIESK ISMTGYSITN KNTSTSNESG 800
    VHFELTK 807
    Length:807
    Mass (Da):91,985
    Last modified:November 1, 1996 - v1
    Checksum:iFFE88EDC07418EB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21221 Genomic DNA. Translation: AAA82984.1.
    CP000253 Genomic DNA. Translation: ABD31483.1.
    RefSeqiWP_000222239.1. NC_007795.1.
    YP_500931.1. NC_007795.1.

    Genome annotation databases

    EnsemblBacteriaiABD31483; ABD31483; SAOUHSC_02463.
    GeneIDi3919026.
    KEGGisao:SAOUHSC_02463.
    PATRICi19582232. VBIStaAur99865_2222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U21221 Genomic DNA. Translation: AAA82984.1 .
    CP000253 Genomic DNA. Translation: ABD31483.1 .
    RefSeqi WP_000222239.1. NC_007795.1.
    YP_500931.1. NC_007795.1.

    3D structure databases

    ProteinModelPortali Q59801.
    SMRi Q59801. Positions 49-778.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 93061.SAOUHSC_02463.

    Protein family/group databases

    CAZyi PL8. Polysaccharide Lyase Family 8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD31483 ; ABD31483 ; SAOUHSC_02463 .
    GeneIDi 3919026.
    KEGGi sao:SAOUHSC_02463.
    PATRICi 19582232. VBIStaAur99865_2222.

    Phylogenomic databases

    eggNOGi NOG04835.
    HOGENOMi HOG000280193.
    KOi K01727.
    OMAi RYYQDET.
    OrthoDBi EOG6GBM67.

    Enzyme and pathway databases

    BioCyci SAUR93061:GIWJ-2399-MONOMER.

    Miscellaneous databases

    PROi Q59801.

    Family and domain databases

    Gene3Di 1.50.10.100. 1 hit.
    2.60.220.10. 1 hit.
    2.70.98.10. 1 hit.
    InterProi IPR008929. Chondroitin_lyas.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR011071. Lyase_8-like_C.
    IPR012970. Lyase_8_alpha_N.
    IPR004103. Lyase_8_C.
    IPR003159. Lyase_8_central_dom.
    IPR012329. Lyase_8_N.
    [Graphical view ]
    Pfami PF02278. Lyase_8. 1 hit.
    PF02884. Lyase_8_C. 1 hit.
    PF08124. Lyase_8_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48230. SSF48230. 1 hit.
    SSF49863. SSF49863. 1 hit.
    SSF74650. SSF74650. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, nucleotide sequence determination and expression of the Staphylococcus aureus hyaluronate lyase gene."
      Farrell A.M., Taylor D., Holland K.T.
      FEMS Microbiol. Lett. 130:81-85(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The Staphylococcus aureus NCTC 8325 genome."
      Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.
      (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.); Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C. (2006)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCTC 8325.

    Entry informationi

    Entry nameiHYSA_STAA8
    AccessioniPrimary (citable) accession number: Q59801
    Secondary accession number(s): Q2FW54
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3