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Q59776

- CISY_RICS1

UniProt

Q59776 - CISY_RICS1

Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia slovaca (strain 13-B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei311 – 3111PROSITE-ProRule annotation
    Active sitei370 – 3701PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciRSLO941638:GJCO-1258-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    Ordered Locus Names:Rsl_1491
    OrganismiRickettsia slovaca (strain 13-B)
    Taxonomic identifieri941638 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000005443: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Citrate synthasePRO_0000169970Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ59776.
    SMRiQ59776. Positions 12-430.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    KOiK01647.
    OMAiKETCDEV.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59776-1 [UniParc]FASTAAdd to Basket

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    MTNENNNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SAEADCFTYD    50
    PGFMSTASCQ STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE 100
    LPSGEQYNNF TKQVAHHSLV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA 150
    FYPDLLNFKE ADYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT 200
    ENFLHMMFAT PCTKYTVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS 250
    GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSEYI PKYIAKAKDK 300
    NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLDN NPLLQIAIEL 350
    EAIALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM 400
    AQWKEMHEDP EQKISRPRQL YTGYVHREYK GIRER 435
    Length:435
    Mass (Da):49,176
    Last modified:April 18, 2012 - v2
    Checksum:iAB5682B38B0A27F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002428 Genomic DNA. Translation: AEV92756.1.
    U59725 Genomic DNA. Translation: AAB02969.1.
    RefSeqiYP_005066324.1. NC_016639.1.

    Genome annotation databases

    EnsemblBacteriaiAEV92756; AEV92756; Rsl_1491.
    GeneIDi11582813.
    KEGGirsv:Rsl_1491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002428 Genomic DNA. Translation: AEV92756.1 .
    U59725 Genomic DNA. Translation: AAB02969.1 .
    RefSeqi YP_005066324.1. NC_016639.1.

    3D structure databases

    ProteinModelPortali Q59776.
    SMRi Q59776. Positions 12-430.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEV92756 ; AEV92756 ; Rsl_1491 .
    GeneIDi 11582813.
    KEGGi rsv:Rsl_1491.

    Phylogenomic databases

    KOi K01647.
    OMAi KETCDEV.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci RSLO941638:GJCO-1258-MONOMER.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rickettsia slovaca, the agent of tick-borne lymphadenitis."
      Fournier P.E., El Karkouri K., Robert C., Medigue C., Raoult D.
      J. Bacteriol. 194:1612-1612(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 13-B.
    2. "Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
      Roux V., Rydkina E., Eremeeva M., Raoult D.
      Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418.
      Strain: 13-B.

    Entry informationi

    Entry nameiCISY_RICS1
    AccessioniPrimary (citable) accession number: Q59776
    Secondary accession number(s): G8LC39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3