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Q59776

- CISY_RICS1

UniProt

Q59776 - CISY_RICS1

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Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia slovaca (strain 13-B)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei311 – 3111PROSITE-ProRule annotation
Active sitei370 – 3701PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciRSLO941638:GJCO-1258-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:Rsl_1491
OrganismiRickettsia slovaca (strain 13-B)
Taxonomic identifieri941638 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000005443: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Citrate synthasePRO_0000169970Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ59776.
SMRiQ59776. Positions 12-430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

KOiK01647.
OMAiKETCDEV.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59776-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNENNNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SAEADCFTYD
60 70 80 90 100
PGFMSTASCQ STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE
110 120 130 140 150
LPSGEQYNNF TKQVAHHSLV NERLHYLFQT FCSSSHPMAI MLAAVGSLSA
160 170 180 190 200
FYPDLLNFKE ADYELTAIRM IAKIPTIAAM SYKYSIGQPF IYPDNSLDFT
210 220 230 240 250
ENFLHMMFAT PCTKYTVNPI IKNALNKIFI LHADHEQNAS TSTVRIAGSS
260 270 280 290 300
GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSEYI PKYIAKAKDK
310 320 330 340 350
NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLDN NPLLQIAIEL
360 370 380 390 400
EAIALKDEYF IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM
410 420 430
AQWKEMHEDP EQKISRPRQL YTGYVHREYK GIRER
Length:435
Mass (Da):49,176
Last modified:April 18, 2012 - v2
Checksum:iAB5682B38B0A27F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002428 Genomic DNA. Translation: AEV92756.1.
U59725 Genomic DNA. Translation: AAB02969.1.
RefSeqiYP_005066324.1. NC_016639.1.

Genome annotation databases

EnsemblBacteriaiAEV92756; AEV92756; Rsl_1491.
GeneIDi11582813.
KEGGirsv:Rsl_1491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002428 Genomic DNA. Translation: AEV92756.1 .
U59725 Genomic DNA. Translation: AAB02969.1 .
RefSeqi YP_005066324.1. NC_016639.1.

3D structure databases

ProteinModelPortali Q59776.
SMRi Q59776. Positions 12-430.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEV92756 ; AEV92756 ; Rsl_1491 .
GeneIDi 11582813.
KEGGi rsv:Rsl_1491.

Phylogenomic databases

KOi K01647.
OMAi KETCDEV.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci RSLO941638:GJCO-1258-MONOMER.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of Rickettsia slovaca, the agent of tick-borne lymphadenitis."
    Fournier P.E., El Karkouri K., Robert C., Medigue C., Raoult D.
    J. Bacteriol. 194:1612-1612(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 13-B.
  2. "Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
    Roux V., Rydkina E., Eremeeva M., Raoult D.
    Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418.
    Strain: 13-B.

Entry informationi

Entry nameiCISY_RICS1
AccessioniPrimary (citable) accession number: Q59776
Secondary accession number(s): G8LC39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 18, 2012
Last modified: October 1, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3