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Q59776 (CISY_RICS1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.16
Gene names
Name:gltA
Ordered Locus Names:Rsl_1491
OrganismRickettsia slovaca (strain 13-B) [Complete proteome] [HAMAP]
Taxonomic identifier941638 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Citrate synthase
PRO_0000169970

Sites

Active site3111 By similarity
Active site3701 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59776 [UniParc].

Last modified April 18, 2012. Version 2.
Checksum: AB5682B38B0A27F3

FASTA43549,176
        10         20         30         40         50         60 
MTNENNNDSE FAELKIRGKI FKLPILKASI GEDVIDISRV SAEADCFTYD PGFMSTASCQ 

        70         80         90        100        110        120 
STITYIDGDK GILRHRGYDI KDLAEKSDFL EVAYLLIYGE LPSGEQYNNF TKQVAHHSLV 

       130        140        150        160        170        180 
NERLHYLFQT FCSSSHPMAI MLAAVGSLSA FYPDLLNFKE ADYELTAIRM IAKIPTIAAM 

       190        200        210        220        230        240 
SYKYSIGQPF IYPDNSLDFT ENFLHMMFAT PCTKYTVNPI IKNALNKIFI LHADHEQNAS 

       250        260        270        280        290        300 
TSTVRIAGSS GANPFACIST GIASLWGPAH GGANEAVINM LKEIGSSEYI PKYIAKAKDK 

       310        320        330        340        350        360 
NDPFRLMGFG HRVYKNYDPR AAVLKETCKE VLKELGQLDN NPLLQIAIEL EAIALKDEYF 

       370        380        390        400        410        420 
IERKLYPNVD FYSGIIYKAM GIPSQMFTVL FAIARTVGWM AQWKEMHEDP EQKISRPRQL 

       430 
YTGYVHREYK GIRER 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of Rickettsia slovaca, the agent of tick-borne lymphadenitis."
Fournier P.E., El Karkouri K., Robert C., Medigue C., Raoult D.
J. Bacteriol. 194:1612-1612(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 13-B.
[2]"Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
Roux V., Rydkina E., Eremeeva M., Raoult D.
Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-418.
Strain: 13-B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002428 Genomic DNA. Translation: AEV92756.1.
U59725 Genomic DNA. Translation: AAB02969.1.
RefSeqYP_005066324.1. NC_016639.1.

3D structure databases

ProteinModelPortalQ59776.
SMRQ59776. Positions 12-430.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEV92756; AEV92756; Rsl_1491.
GeneID11582813.
KEGGrsv:Rsl_1491.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01647.
OMAKETCDEV.

Enzyme and pathway databases

BioCycRSLO941638:GJCO-1258-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_RICS1
AccessionPrimary (citable) accession number: Q59776
Secondary accession number(s): G8LC39
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: April 18, 2012
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways