Q59758 (DNAA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	RP601

Organism

Rickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]

Taxonomic identifier

272947 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group › Rickettsia prowazekii

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP-Rule MF_00377
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Chromosomal replication initiator protein DnaA HAMAP-Rule MF_00377		PRO_0000114247
Regions
	Nucleotide binding	168 – 175	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q59758 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F3CA5683DD3BB1A1	FASTA	463	53,005
	10 20 30 40 50 60 MSTNQIPLTD QGDNYVNVWS YVAQDLYNHY GETLYNSWFS KVNFIESSLN TVILCAPTNF 70 80 90 100 110 120 IRDWIKSKYA MVILQLFQHY NNAIKSIEII TKELPGTTQA VIESPTKTFA DIGNSALNSE 130 140 150 160 170 180 NIVSTLDVRF TFDNFVVGVP NELAYAAARA VAESSGAVFE SNPLFLYGGV GLGKTHLMHA 190 200 210 220 230 240 IGWYIKQNNP RRKVIYMSAE KFMYQFVKAL RNKEVILFKE KFRSVDVLMI DDIQFICGKD 250 260 270 280 290 300 STQEEFFHTF NTLIDNNRQM VISCDRSPSD LDNIEDRIKS RLGWGLVADV HSTTYELRLG 310 320 330 340 350 360 ILESKIEQMN VKIPKDVINF LASKIVSNVR ELEGALNKVI AHSNFTLKAI TLENTQNILR 370 380 390 400 410 420 DLLRSNERII TVEDIQKKVA SRYNIKLSDM YSSRRLREVA RPRQIAMYLS KTLTPKSLAD 430 440 450 460 IGKKFGKKDH TTVMHAIKKV EELLENDIEL REEINLLMKI LQN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of the dnaA gene of Rickettsia prowazekii." Waite R.T., Shaw E.I., Winkler H.H., Wood D.O. Acta Virol. 42:95-101(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Madrid E.
[2]	"The genome sequence of Rickettsia prowazekii and the origin of mitochondria." Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G. Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Madrid E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U55213 Genomic DNA. Translation: AAA99160.1. AJ235272 Genomic DNA. Translation: CAA15045.1.
PIR	C71665.
RefSeq	NP_220969.1. NC_000963.1.
3D structure databases
ProteinModelPortal	Q59758.
ModBase	Search...
Protein-protein interaction databases
STRING	272947.RP601.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAA15045; CAA15045; CAA15045.
GeneID	883515.
KEGG	rpr:RP601.
PATRIC	17902017. VBIRicPro72556_0619.
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HOG000235660.
KO	K02313.
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Family and domain databases
Gene3D	1.10.1750.10. 1 hit.
HAMAP	MF_00377. DnaA_bact.
InterPro	IPR003593. AAA+_ATPase. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR024633. DnaA_N_dom. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. PF11638. DnaA_N. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_RICPR

Accession

Primary (citable) accession number: Q59758

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program