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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi168 – 175ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPRO272947:G1GT0-601-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaA
Gene namesi
Name:dnaA
Ordered Locus Names:RP601
OrganismiRickettsia prowazekii (strain Madrid E)
Taxonomic identifieri272947 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000002480 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001142471 – 463Chromosomal replication initiator protein DnaAAdd BLAST463

Interactioni

Protein-protein interaction databases

STRINGi272947.RP601

Structurei

3D structure databases

ProteinModelPortaliQ59758
SMRiQ59758
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.Curated

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
HOGENOMiHOG000235660
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q59758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTNQIPLTD QGDNYVNVWS YVAQDLYNHY GETLYNSWFS KVNFIESSLN
60 70 80 90 100
TVILCAPTNF IRDWIKSKYA MVILQLFQHY NNAIKSIEII TKELPGTTQA
110 120 130 140 150
VIESPTKTFA DIGNSALNSE NIVSTLDVRF TFDNFVVGVP NELAYAAARA
160 170 180 190 200
VAESSGAVFE SNPLFLYGGV GLGKTHLMHA IGWYIKQNNP RRKVIYMSAE
210 220 230 240 250
KFMYQFVKAL RNKEVILFKE KFRSVDVLMI DDIQFICGKD STQEEFFHTF
260 270 280 290 300
NTLIDNNRQM VISCDRSPSD LDNIEDRIKS RLGWGLVADV HSTTYELRLG
310 320 330 340 350
ILESKIEQMN VKIPKDVINF LASKIVSNVR ELEGALNKVI AHSNFTLKAI
360 370 380 390 400
TLENTQNILR DLLRSNERII TVEDIQKKVA SRYNIKLSDM YSSRRLREVA
410 420 430 440 450
RPRQIAMYLS KTLTPKSLAD IGKKFGKKDH TTVMHAIKKV EELLENDIEL
460
REEINLLMKI LQN
Length:463
Mass (Da):53,005
Last modified:November 1, 1996 - v1
Checksum:iF3CA5683DD3BB1A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55213 Genomic DNA Translation: AAA99160.1
AJ235272 Genomic DNA Translation: CAA15045.1
PIRiC71665
RefSeqiNP_220969.1, NC_000963.1
WP_004597944.1, NC_000963.1

Genome annotation databases

EnsemblBacteriaiCAA15045; CAA15045; CAA15045
GeneIDi883515
KEGGirpr:RP601
PATRICifig|272947.5.peg.619

Similar proteinsi

Entry informationi

Entry nameiDNAA_RICPR
AccessioniPrimary (citable) accession number: Q59758
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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