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Q59758 (DNAA_RICPR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromosomal replication initiator protein DnaA
Gene names
Name:dnaA
Ordered Locus Names:RP601
OrganismRickettsia prowazekii (strain Madrid E) [Reference proteome] [HAMAP]
Taxonomic identifier272947 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP-Rule MF_00377

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00377.

Sequence similarities

Belongs to the DnaA family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentCytoplasm
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication initiation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

regulation of DNA replication

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA replication origin binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463Chromosomal replication initiator protein DnaA HAMAP-Rule MF_00377
PRO_0000114247

Regions

Nucleotide binding168 – 1758ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q59758 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F3CA5683DD3BB1A1

FASTA46353,005
        10         20         30         40         50         60 
MSTNQIPLTD QGDNYVNVWS YVAQDLYNHY GETLYNSWFS KVNFIESSLN TVILCAPTNF 

        70         80         90        100        110        120 
IRDWIKSKYA MVILQLFQHY NNAIKSIEII TKELPGTTQA VIESPTKTFA DIGNSALNSE 

       130        140        150        160        170        180 
NIVSTLDVRF TFDNFVVGVP NELAYAAARA VAESSGAVFE SNPLFLYGGV GLGKTHLMHA 

       190        200        210        220        230        240 
IGWYIKQNNP RRKVIYMSAE KFMYQFVKAL RNKEVILFKE KFRSVDVLMI DDIQFICGKD 

       250        260        270        280        290        300 
STQEEFFHTF NTLIDNNRQM VISCDRSPSD LDNIEDRIKS RLGWGLVADV HSTTYELRLG 

       310        320        330        340        350        360 
ILESKIEQMN VKIPKDVINF LASKIVSNVR ELEGALNKVI AHSNFTLKAI TLENTQNILR 

       370        380        390        400        410        420 
DLLRSNERII TVEDIQKKVA SRYNIKLSDM YSSRRLREVA RPRQIAMYLS KTLTPKSLAD 

       430        440        450        460 
IGKKFGKKDH TTVMHAIKKV EELLENDIEL REEINLLMKI LQN 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the dnaA gene of Rickettsia prowazekii."
Waite R.T., Shaw E.I., Winkler H.H., Wood D.O.
Acta Virol. 42:95-101(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Madrid E.
[2]"The genome sequence of Rickettsia prowazekii and the origin of mitochondria."
Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T., Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H., Kurland C.G.
Nature 396:133-140(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Madrid E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U55213 Genomic DNA. Translation: AAA99160.1.
AJ235272 Genomic DNA. Translation: CAA15045.1.
PIRC71665.
RefSeqNP_220969.1. NC_000963.1.

3D structure databases

ProteinModelPortalQ59758.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272947.RP601.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAA15045; CAA15045; CAA15045.
GeneID883515.
KEGGrpr:RP601.
PATRIC17902017. VBIRicPro72556_0619.

Phylogenomic databases

eggNOGCOG0593.
HOGENOMHOG000235660.
KOK02313.
OMANRTFTFD.
OrthoDBEOG689HR1.

Family and domain databases

Gene3D1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00377. DnaA_bact.
InterProIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSPR00051. DNAA.
SMARTSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00362. DnaA. 1 hit.
PROSITEPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAA_RICPR
AccessionPrimary (citable) accession number: Q59758
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Rickettsia prowazekii

Rickettsia prowazekii (strain Madrid E): entries and gene names