Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q59758

- DNAA_RICPR

UniProt

Q59758 - DNAA_RICPR

Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Rickettsia prowazekii (strain Madrid E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi168 – 1758ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA replication origin binding Source: UniProtKB-HAMAP
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. DNA replication initiation Source: UniProtKB-HAMAP
    2. regulation of DNA replication Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromosomal replication initiator protein DnaA
    Gene namesi
    Name:dnaA
    Ordered Locus Names:RP601
    OrganismiRickettsia prowazekii (strain Madrid E)
    Taxonomic identifieri272947 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000002480: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 463463Chromosomal replication initiator protein DnaAPRO_0000114247Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272947.RP601.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59758.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DnaA family.Curated

    Phylogenomic databases

    eggNOGiCOG0593.
    HOGENOMiHOG000235660.
    KOiK02313.
    OMAiNRTFTFD.
    OrthoDBiEOG689HR1.

    Family and domain databases

    Gene3Di1.10.1750.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00377. DnaA_bact.
    InterProiIPR003593. AAA+_ATPase.
    IPR001957. Chromosome_initiator_DnaA.
    IPR020591. Chromosome_initiator_DnaA-like.
    IPR018312. Chromosome_initiator_DnaA_CS.
    IPR013159. DnaA_C.
    IPR013317. DnaA_Hda.
    IPR024633. DnaA_N_dom.
    IPR027417. P-loop_NTPase.
    IPR010921. Trp_repressor/repl_initiator.
    [Graphical view]
    PfamiPF00308. Bac_DnaA. 1 hit.
    PF08299. Bac_DnaA_C. 1 hit.
    PF11638. DnaA_N. 1 hit.
    [Graphical view]
    PRINTSiPR00051. DNAA.
    SMARTiSM00382. AAA. 1 hit.
    SM00760. Bac_DnaA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48295. SSF48295. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00362. DnaA. 1 hit.
    PROSITEiPS01008. DNAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59758-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTNQIPLTD QGDNYVNVWS YVAQDLYNHY GETLYNSWFS KVNFIESSLN    50
    TVILCAPTNF IRDWIKSKYA MVILQLFQHY NNAIKSIEII TKELPGTTQA 100
    VIESPTKTFA DIGNSALNSE NIVSTLDVRF TFDNFVVGVP NELAYAAARA 150
    VAESSGAVFE SNPLFLYGGV GLGKTHLMHA IGWYIKQNNP RRKVIYMSAE 200
    KFMYQFVKAL RNKEVILFKE KFRSVDVLMI DDIQFICGKD STQEEFFHTF 250
    NTLIDNNRQM VISCDRSPSD LDNIEDRIKS RLGWGLVADV HSTTYELRLG 300
    ILESKIEQMN VKIPKDVINF LASKIVSNVR ELEGALNKVI AHSNFTLKAI 350
    TLENTQNILR DLLRSNERII TVEDIQKKVA SRYNIKLSDM YSSRRLREVA 400
    RPRQIAMYLS KTLTPKSLAD IGKKFGKKDH TTVMHAIKKV EELLENDIEL 450
    REEINLLMKI LQN 463
    Length:463
    Mass (Da):53,005
    Last modified:November 1, 1996 - v1
    Checksum:iF3CA5683DD3BB1A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55213 Genomic DNA. Translation: AAA99160.1.
    AJ235272 Genomic DNA. Translation: CAA15045.1.
    PIRiC71665.
    RefSeqiNP_220969.1. NC_000963.1.

    Genome annotation databases

    EnsemblBacteriaiCAA15045; CAA15045; CAA15045.
    GeneIDi883515.
    KEGGirpr:RP601.
    PATRICi17902017. VBIRicPro72556_0619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55213 Genomic DNA. Translation: AAA99160.1 .
    AJ235272 Genomic DNA. Translation: CAA15045.1 .
    PIRi C71665.
    RefSeqi NP_220969.1. NC_000963.1.

    3D structure databases

    ProteinModelPortali Q59758.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272947.RP601.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAA15045 ; CAA15045 ; CAA15045 .
    GeneIDi 883515.
    KEGGi rpr:RP601.
    PATRICi 17902017. VBIRicPro72556_0619.

    Phylogenomic databases

    eggNOGi COG0593.
    HOGENOMi HOG000235660.
    KOi K02313.
    OMAi NRTFTFD.
    OrthoDBi EOG689HR1.

    Family and domain databases

    Gene3Di 1.10.1750.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00377. DnaA_bact.
    InterProi IPR003593. AAA+_ATPase.
    IPR001957. Chromosome_initiator_DnaA.
    IPR020591. Chromosome_initiator_DnaA-like.
    IPR018312. Chromosome_initiator_DnaA_CS.
    IPR013159. DnaA_C.
    IPR013317. DnaA_Hda.
    IPR024633. DnaA_N_dom.
    IPR027417. P-loop_NTPase.
    IPR010921. Trp_repressor/repl_initiator.
    [Graphical view ]
    Pfami PF00308. Bac_DnaA. 1 hit.
    PF08299. Bac_DnaA_C. 1 hit.
    PF11638. DnaA_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00051. DNAA.
    SMARTi SM00382. AAA. 1 hit.
    SM00760. Bac_DnaA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48295. SSF48295. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00362. DnaA. 1 hit.
    PROSITEi PS01008. DNAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the dnaA gene of Rickettsia prowazekii."
      Waite R.T., Shaw E.I., Winkler H.H., Wood D.O.
      Acta Virol. 42:95-101(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Madrid E.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Madrid E.

    Entry informationi

    Entry nameiDNAA_RICPR
    AccessioniPrimary (citable) accession number: Q59758
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Rickettsia prowazekii
      Rickettsia prowazekii (strain Madrid E): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3