Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q59748 (CISY_RICMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
OrganismRickettsia massiliae
Taxonomic identifier35791 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length411 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›411›411Citrate synthase
PRO_0000169965

Sites

Active site3041 By similarity
Active site3631 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue4111

Sequences

Sequence LengthMass (Da)Tools
Q59748 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 50271726F554B8B5

FASTA41146,277
        10         20         30         40         50         60 
DSEFAELKIR GKIFKLPILK ASIGEDVIDI SRVSAEADCF TYDPGFMSTA SCQSTITYID 

        70         80         90        100        110        120 
GDKGILRHRG YDIKDLAEKS DFLEVAYLLI YGELPSGEQY NNFTKQVAHH SLVNERLHYL 

       130        140        150        160        170        180 
FQTFCSSSHP MAIMLAAVGS LSAFYPDLLN FKEADYELTA IRMIAKIPTI AAMSYKYSIG 

       190        200        210        220        230        240 
QPFIYPDNSL DFTENFLHMM FATPCTKYKV NPIIKNALNK IFILHADHEQ NASTSTVRIA 

       250        260        270        280        290        300 
GSSGANPFAC ISTGIASLWG PAHGGANEVV INMLKEIGSS EYIPKYIAKA KDKNDPFRLM 

       310        320        330        340        350        360 
GFGHRIYKNY DPRAAVLKET CKEVLKELGQ LDNNPLLQIA IELEAIALKD EYFIERKLYP 

       370        380        390        400        410 
NVDFYSGIIY KAMGIPSQMF TVLFAIARTV GWMAQWKEMH EDPEQKISRP R 

« Hide

References

[1]"Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
Roux V., Rydkina E., Eremeeva M., Raoult D.
Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Mtu1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59719 Genomic DNA. Translation: AAB02961.1.

3D structure databases

ProteinModelPortalQ59748.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_RICMA
AccessionPrimary (citable) accession number: Q59748
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways