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Q59734

- CISY_RICBE

UniProt

Q59734 - CISY_RICBE

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Protein
Citrate synthase
Gene
gltA
Organism
Rickettsia bellii
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei305 – 3051 By similarity
Active sitei364 – 3641 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
OrganismiRickettsia bellii
Taxonomic identifieri33990 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›412›412Citrate synthase
PRO_0000169959Add
BLAST

Proteomic databases

PRIDEiQ59734.

Structurei

3D structure databases

ProteinModelPortaliQ59734.
SMRiQ59734. Positions 11-412.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59734-1 [UniParc]FASTAAdd to Basket

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NTEFAELKIR DKIFKLPILK ASIGQDVIDI SKVYSEADCF TYDPGFMSTA    50
SCRSTITYID GDQGILRHRG YDIKDLAEKS DFLEVAYLLI YGELPNNKQY 100
NDFTKKVAHH ALVNERLHYL FQTFCSSSHP MAIMLAAVGS LSAFYPDLLN 150
FFKEADYELT AIRMIAKIPT IAAMSYKYSI GQPFVYPDNS LDFTENFLHM 200
MFATPCEKYK VNPVIKNALN KIFILHADHE QNASTSTVRI AGSSGANPFA 250
CVSTGIASLW GPAHGGANEA VINMLKEIGS VENIPKYIAK AKDKNDNFRL 300
MGFGHRVYKN YDPRAAVLKE TCKEVLKELG QLDNNPLLQI AIELEAIALK 350
DEYFIERKLY PNVDFYSGII YKAMGIPPQM FTVLFATART VGWMAQWKEM 400
HEDPEQKISR PR 412
Length:412
Mass (Da):46,577
Last modified:November 1, 1997 - v1
Checksum:i0516370DF8D3FC3D
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei412 – 4121

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59716 Genomic DNA. Translation: AAB02956.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U59716 Genomic DNA. Translation: AAB02956.1 .

3D structure databases

ProteinModelPortali Q59734.
SMRi Q59734. Positions 11-412.
ModBasei Search...

Proteomic databases

PRIDEi Q59734.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
    Roux V., Rydkina E., Eremeeva M., Raoult D.
    Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 369L42-1.

Entry informationi

Entry nameiCISY_RICBE
AccessioniPrimary (citable) accession number: Q59734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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