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Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia bellii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA), Citrate synthase (gltA)
  2. no protein annotated in this organism
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei305PROSITE-ProRule annotation1
Active sitei364PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
OrganismiRickettsia bellii
Taxonomic identifieri33990 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000169959‹1 – ›412Citrate synthaseAdd BLAST›412

Proteomic databases

PRIDEiQ59734.

Structurei

3D structure databases

ProteinModelPortaliQ59734.
SMRiQ59734.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZN. Bacteria.
COG0372. LUCA.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiView protein in InterPro
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
PfamiView protein in Pfam
PF00285. Citrate_synt. 1 hit.
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiView protein in PROSITE
PS00480. CITRATE_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
NTEFAELKIR DKIFKLPILK ASIGQDVIDI SKVYSEADCF TYDPGFMSTA
60 70 80 90 100
SCRSTITYID GDQGILRHRG YDIKDLAEKS DFLEVAYLLI YGELPNNKQY
110 120 130 140 150
NDFTKKVAHH ALVNERLHYL FQTFCSSSHP MAIMLAAVGS LSAFYPDLLN
160 170 180 190 200
FFKEADYELT AIRMIAKIPT IAAMSYKYSI GQPFVYPDNS LDFTENFLHM
210 220 230 240 250
MFATPCEKYK VNPVIKNALN KIFILHADHE QNASTSTVRI AGSSGANPFA
260 270 280 290 300
CVSTGIASLW GPAHGGANEA VINMLKEIGS VENIPKYIAK AKDKNDNFRL
310 320 330 340 350
MGFGHRVYKN YDPRAAVLKE TCKEVLKELG QLDNNPLLQI AIELEAIALK
360 370 380 390 400
DEYFIERKLY PNVDFYSGII YKAMGIPPQM FTVLFATART VGWMAQWKEM
410
HEDPEQKISR PR
Length:412
Mass (Da):46,577
Last modified:November 1, 1997 - v1
Checksum:i0516370DF8D3FC3D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei4121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59716 Genomic DNA. Translation: AAB02956.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCISY_RICBE
AccessioniPrimary (citable) accession number: Q59734
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families