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Q59734 (CISY_RICBE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
OrganismRickettsia bellii
Taxonomic identifier33990 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiabelli group

Protein attributes

Sequence length412 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›412›412Citrate synthase
PRO_0000169959

Sites

Active site3051 By similarity
Active site3641 By similarity

Experimental info

Non-terminal residue11
Non-terminal residue4121

Sequences

Sequence LengthMass (Da)Tools
Q59734 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 0516370DF8D3FC3D

FASTA41246,577
        10         20         30         40         50         60 
NTEFAELKIR DKIFKLPILK ASIGQDVIDI SKVYSEADCF TYDPGFMSTA SCRSTITYID 

        70         80         90        100        110        120 
GDQGILRHRG YDIKDLAEKS DFLEVAYLLI YGELPNNKQY NDFTKKVAHH ALVNERLHYL 

       130        140        150        160        170        180 
FQTFCSSSHP MAIMLAAVGS LSAFYPDLLN FFKEADYELT AIRMIAKIPT IAAMSYKYSI 

       190        200        210        220        230        240 
GQPFVYPDNS LDFTENFLHM MFATPCEKYK VNPVIKNALN KIFILHADHE QNASTSTVRI 

       250        260        270        280        290        300 
AGSSGANPFA CVSTGIASLW GPAHGGANEA VINMLKEIGS VENIPKYIAK AKDKNDNFRL 

       310        320        330        340        350        360 
MGFGHRVYKN YDPRAAVLKE TCKEVLKELG QLDNNPLLQI AIELEAIALK DEYFIERKLY 

       370        380        390        400        410 
PNVDFYSGII YKAMGIPPQM FTVLFATART VGWMAQWKEM HEDPEQKISR PR 

« Hide

References

[1]"Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
Roux V., Rydkina E., Eremeeva M., Raoult D.
Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 369L42-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U59716 Genomic DNA. Translation: AAB02956.1.

3D structure databases

ProteinModelPortalQ59734.
SMRQ59734. Positions 11-412.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ59734.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_RICBE
AccessionPrimary (citable) accession number: Q59734
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways