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Q59730

- CISY_RICAK

UniProt

Q59730 - CISY_RICAK

Protein

Citrate synthase

Gene

gltA

Organism
Rickettsia akari
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei304 – 3041PROSITE-ProRule annotation
    Active sitei363 – 3631PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase (EC:2.3.3.16)
    Gene namesi
    Name:gltA
    OrganismiRickettsia akari
    Taxonomic identifieri786 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›411›411Citrate synthasePRO_0000169957Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ59730.
    SMRiQ59730. Positions 5-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59730-1 [UniParc]FASTAAdd to Basket

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    DSEFAELKIR GKIFQLPILK ASIGEDVIDI SRVSAEVNCF TYDPGFMSTA    50
    SCKSTITYID GDKGILRHRG YNIKDLAEKS DFLEVAYLLI YGELPSIEQY 100
    NNFTKQVAHH SLVNERLHYL FQTFCSSSHP MAIMLAAIGS LSAFYPDLLN 150
    FKEADYELTA IRMIAKIPTI AAMSYKYSIG QPFVYPDNSL DFTENFLHMM 200
    FATPCTKYKV NPIIKNALNK IFILHADHEQ NASTSTVRIA GSSGANAFAC 250
    ISTGIASLWG PAHGGANEAV INMLKEIGSS ENIPKYIAKA KDKSDPFRLM 300
    GFGHRVYKNY DPRASVLKET CKEVLKELGQ LENNPLLQIA IELEAIALKD 350
    EYFIERKLYP NVDFYSGIIY KAMGIPSQMF TVLFAIARTV GWMAQWKEMH 400
    EDPGQKISRP R 411
    Length:411
    Mass (Da):46,173
    Last modified:November 1, 1997 - v1
    Checksum:i8FEBC66C3CB5FB11
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei411 – 4111

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59717 Genomic DNA. Translation: AAB02953.1.
    U41752 Genomic DNA. Translation: AAB49577.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59717 Genomic DNA. Translation: AAB02953.1 .
    U41752 Genomic DNA. Translation: AAB49577.1 .

    3D structure databases

    ProteinModelPortali Q59730.
    SMRi Q59730. Positions 5-411.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    IPR010953. Citrate_synthase_typ-I.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Citrate synthase gene comparison, a new tool for phylogenetic analysis, and its application for the rickettsiae."
      Roux V., Rydkina E., Eremeeva M., Raoult D.
      Int. J. Syst. Bacteriol. 47:252-261(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: MK / Kaplan.
    2. Azad A.F., Higgins J.A., Radulovic S., Schriefer M.E.
      Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-385.
      Strain: MK / Kaplan.

    Entry informationi

    Entry nameiCISY_RICAK
    AccessioniPrimary (citable) accession number: Q59730
    Secondary accession number(s): Q59729
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3