Q59688 (Q59688_PROMI) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Heavy-metal transporting P-type ATPase EMBL AAB01764.1
Organism	Proteus mirabilis EMBL AAB01764.1
Taxonomic identifier	584 [NCBI]
Taxonomic lineage	Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length	829 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. RuleBase RU000653

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000653
Ligand	ATP-binding RuleBase RU000653 Nucleotide-binding
Molecular function	Hydrolase RuleBase RU000653
PTM	Phosphoprotein RuleBase RU000653
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: InterPro copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	829	1	EMBL AAB01764.1

Sequences

	Sequence		Length	Mass (Da)
	Q59688 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 836B929DD006E340	FASTA	829	87,860
	10 20 30 40 50 60 MNTPTTLSSA NRLSLPVEGM TCASCVGRVE RALKAVPEIK DAVVNLATER ADITFSSTPN 70 80 90 100 110 120 PVLAVSAIES SGYKVPEEIT ELAIEEMTCA SCVGRVEKAL AQIPGVLEAT VNLATERARV 130 140 150 160 170 180 RHLSGVVSIT DLEVAVVHAG YKPRRLSDNP ANTRDLSEER REKEARSLRR ALLIATIFTL 190 200 210 220 230 240 PVFVIEMGSH FIPGVHHWVT QTLGQQLNWY IQFVLATIVM FGPGLRFFKK GIPALLRGAP 250 260 270 280 290 300 DMNSLVSVGT VAAYGYSVVS TFIPQVLPAG TANIYFEAAV VIVTLILLGR NLEAKAKGNT 310 320 330 340 350 360 SQAIKRLVGL QAKTARVSRH GEILEIPLDQ VMMGDIVVVR PGEKIPVDGE VVEGHSYVDE 370 380 390 400 410 420 SMITGEPVPV AKEIGAEVVG GTINKTGTFS FKVTKVGANT ILAQIIRLVE EAQGSKLPIQ 430 440 450 460 470 480 ALVDKVTMWF VPAVMIGATI TFFIWLAFGP EPALTFALIN AVAVLIIACP CAMGLATPTS 490 500 510 520 530 540 IMVGTGRAAE LGILFRKGEA LQALRDVSVV ALDKTGTLTK GRPELTDLIP AEKFEYNEIL 550 560 570 580 590 600 SLVASIETYS EHPIAQSIVN AANEAKLTLA SVDNFEAIPG FGVSATVDGR SVSVGADRFM 610 620 630 640 650 660 KQLGLDVSQF ASSAQKLGEQ GKTPLYTAID GRLAAIIAVA DPIKETTPEA IKALHALGLK 670 680 690 700 710 720 VAMITGDNKA TAKAIAKQLG IDEIVAEVLP DGKVAALKQL SQKGDKVAFV GDGINDAPAL 730 740 750 760 770 780 AQADVGLAIG TGTDVAIEAA DVVLMSGDLR GVVDAIALSQ ATIRNIKQNL FWTFAYNALL 790 800 810 820 IPVAAGMLYP INGMLLSPIF AAAAMALSSV FVLGNALRLK RFQAPMKTH

References

[1]	"Nucleotide sequencing of the Proteus mirabilis calcium-independent hemolysin genes (hpmA and hpmB) reveals sequence similarity with the Serratia marcescens hemolysin genes (shlA and shlB)." Uphoff T.S., Welch R.A. J. Bacteriol. 172:1206-1216(1990) [PubMed: 2407716] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CDC PR 14 EMBL AAB01764.1.
[2]	"A novel heavy-metal transporting ATPase with homology to Wilson and Menkes disease proteins is associated with iron absorption in Proteus mirabilis." Petrukhin K., Efremov R., Lutsenko S., Kaplan J.H., Vergoten G., Gilliam T.C. Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CDC PR 14 EMBL AAB01764.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U42410 Genomic DNA. Translation: AAB01764.1.
3D structure databases
HSSP	HSSP built from PDB template 1P6T based on UniProtKB O32220.
ProteinModelPortal	Q59688.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. IPR023214. HAD-like_dom. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe-assoc_HMA. IPR006122. HMA_Cu_ion-bd. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 1 hit. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 2 hits. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00943. CUATPASE.
SUPFAM	SSF56784. HAD-like_dom. 1 hit. SSF55008. HeavyMe_transpt. 2 hits.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit. TIGR00003. TIGR00003. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 2 hits. PS50846. HMA_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59688_PROMI

Accession

Primary (citable) accession number: Q59688

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 31, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)