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Q59685 (CYAA_PROMI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenylate cyclase
EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene names
Name:cya
OrganismProteus mirabilis
Taxonomic identifier584 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length865 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the adenylyl cyclase class-1 family.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLyase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 865865Adenylate cyclase
PRO_0000195678

Regions

Region1 – 540540Catalytic Potential
Region546 – 865320Regulatory Potential

Sequences

Sequence LengthMass (Da)Tools
Q59685 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 99D4B1DD51FCB7D7

FASTA86599,450
        10         20         30         40         50         60 
MYLYIETLKQ RLDAINQLRL ERAFASMSDV FKQVYGLIPV LLHYHHPQLP GYIQGNVPHG 

        70         80         90        100        110        120 
TCFFEPDDVQ RQWVNKLTNA SCDEPMNGYT SGELPITGIY SMGSTSSIGQ SHCSDIDIWV 

       130        140        150        160        170        180 
CHQSWLDQDE RARLQRKCLL IEQWAGELGI DVTFFLIDEN RFRHHASGSL GGEDCGSTQH 

       190        200        210        220        230        240 
ILLLDEFYRT AVRLAGKRLL WTMVPVEEEY HYDEYVNSLY AQGVLTPNEW LDLGGLGELS 

       250        260        270        280        290        300 
AEEYFGASLW QLYKSVDSPY KAVLKSILLE AYSADYPNGK LLALEMKQHL HRGEIVNYGL 

       310        320        330        340        350        360 
DAYCMMLERV TRYLVSINDL TRLDLIRRCF YLKVCEKLSN EKNENEPAGW RRQVLSQLVT 

       370        380        390        400        410        420 
QWQWDHERLA ILDNRDSWKI ERVRNAHNEL LDTMMQSYRN LIRFARRNNL SVSASPQDIG 

       430        440        450        460        470        480 
VLTRKLYAAF EALPGKVTLV NPQISPDLSE PHLTFIYVPP GRANRSGWYL YNRAPDFAHI 

       490        500        510        520        530        540 
VGHQPLEYNR YLNKLVAWSY FNGLLTKDSQ VYIHQGDSSC DEIKLHELVR DISSHFPIRL 

       550        560        570        580        590        600 
PAPTPKALYS PCEIRHLAII VNLEVDPTER FSDQVVHFDF RKLDVFSFGE EEQCLIGSID 

       610        620        630        640        650        660 
LLYRNSWNEV RTLHFNGTQS MLESLKTILG KMHQDAAPPA SVEVFCYSQH LRGLIRTRVQ 

       670        680        690        700        710        720 
QLVSECIELR LSTNRLEPGR FKALRIAGQT WGLFFERLNV SVQKLENAIE FYGAISYNKL 

       730        740        750        760        770        780 
HGLPVKLGKD ARYLPAVIDG FACEGIIQFF FETTEDNNVF NIYILDEANR VEIYSHCEGS 

       790        800        810        820        830        840 
KEELVKDVSR FYSSSHDRFT YGSSFINFNL PQFYQIVKVD GATQVLPFAG GSFGKLSDLG 

       850        860 
KTAPKEEMST KPIQGFNDYQ AVHHH

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References

[1]"Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes."
Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A.
Biochimie 78:277-287(1996) [PubMed: 8874804] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U22969 Genomic DNA. Translation: AAC44330.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000274. Adenylate_cyclase_1.
IPR024686. Adenylate_cyclase_1_CS.
IPR024685. Adenylate_cyclase_1_N.
[Graphical view]
PfamPF12633. Adenyl_cycl_N. 1 hit.
PF01295. Adenylate_cycl. 1 hit.
[Graphical view]
PIRSFPIRSF001444. Adenylate_cycl. 1 hit.
PROSITEPS01092. ADENYLATE_CYCLASE_1_1. 1 hit.
PS01093. ADENYLATE_CYCLASE_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCYAA_PROMI
AccessionPrimary (citable) accession number: Q59685
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 19, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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