Q59683 (HEM4_PROMI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen-III synthase
Short name=UROS
EC=4.2.1.75

Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase

Gene names

Name:

hemD

Organism

Proteus mirabilis

Taxonomic identifier

584 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.
Catalytic activity	Hydroxymethylbilane = uroporphyrinogen III + H2O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
Sequence similarities	Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological_process	protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	uroporphyrinogen-III synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Uroporphyrinogen-III synthase		PRO_0000135244

Sequences

	Sequence		Length	Mass (Da)
	Q59683 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 4CC1CC06C26D31BA	FASTA	199	22,799
	10 20 30 40 50 60 MSILITRPSP AGEQLTQRLI DAGKHAFHAP LIEIAAGKEL SILENKLNKL STGDYLFLLS 70 80 90 100 110 120 KNAVWYANWQ LNQLQQSWPD TLFYYGIGQS TAEEFQQLTA HSIRYPEFGE TSEDLLALSS 130 140 150 160 170 180 LQQIENKRVL LLRGNGGREL LATTLRQRGA IVDECECYQR LFIDYVSEEF ALKWKNAQVE 190 YLCGHQCEML QQLLSSRWI

References

[1]	"Comparative analysis of the cya locus in enterobacteria and related Gram-negative facultative anaerobes." Trotot P., Sismeiro O., Vivares C., Glaser P., Bresson-Roy A., Danchin A. Biochimie 78:277-287(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U22969 Genomic DNA. Translation: AAC44328.1.
3D structure databases
ProteinModelPortal	Q59683.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00251; UER00320.
Family and domain databases
InterPro	IPR003754. 4pyrrol_synth_uPrphyn_synth. [Graphical view]
Pfam	PF02602. HEM4. 1 hit. [Graphical view]
SUPFAM	SSF69618. HEM4_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HEM4_PROMI

Accession

Primary (citable) accession number: Q59683

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program