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Q59662 (SDHB_PARDE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase iron-sulfur subunit

EC=1.3.5.1
Gene names
Name:sdhB
OrganismParacoccus denitrificans
Taxonomic identifier266 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Succinate dehydrogenase iron-sulfur subunit
PRO_0000158689

Regions

Domain28 – 119922Fe-2S ferredoxin-type
Domain160 – 190314Fe-4S ferredoxin-type

Sites

Metal binding801Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding851Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1001Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1701Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1731Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1761Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1801Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2271Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2331Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2371Iron-sulfur 2 (4Fe-4S) By similarity
Binding site1851Ubiquinone; shared with SdhD subunit By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59662 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F70C21BBA8205B4F

FASTA25929,551
        10         20         30         40         50         60 
MVQLTLPKNS RMRVGKTWPK PEGATNVRRF NIYRWDPDTG ENPRIDTYFV DMDKCGPMVL 

        70         80         90        100        110        120 
DALIKIKNEI DPTLTFRRSC REGICGSCAM NIDGGNHLAC IYGMDEIKGD VNIYPLPHMP 

       130        140        150        160        170        180 
VVKDLVPDLT HFYAQHASVQ PYLITETPTP DKEWRQSIED RKKLDGLYEC VMCASCSTAC 

       190        200        210        220        230        240 
PSYWWNGDRY LGPAALLHAY RWIIDSRDEA TGERLDSLED PFKLYRCHTI MNCTNTCPKG 

       250 
LNPAKAIASI KHMMVDRIV 

« Hide

References

[1]"Cloning, sequencing, and expression of the succinate-ubiquinone oxidoreductase (SdhCDAB) operon from Paracoccus denitrificans."
Dickins M.A., Dhawan T., Gunsalus R.P., Schroeder I., Cecchini G.
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 13543 / NRRL B-3784 / NRC 449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31902 Genomic DNA. Translation: AAA75178.1.
PIRT46881.

3D structure databases

ProteinModelPortalQ59662.
SMRQ59662. Positions 23-254.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_PARDE
AccessionPrimary (citable) accession number: Q59662
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways