Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Paracoccus denitrificans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (bacterial route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase flavoprotein subunit (sdhA), Succinate dehydrogenase iron-sulfur subunit (sdhB)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (bacterial route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei224FADBy similarity1
Binding sitei245SubstrateBy similarity1
Binding sitei257SubstrateBy similarity1
Active sitei289Proton acceptorBy similarity1
Binding sitei356SubstrateBy similarity1
Binding sitei390FADBy similarity1
Binding sitei401SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 22FADBy similarity6
Nucleotide bindingi40 – 55FADBy similarityAdd BLAST16
Nucleotide bindingi406 – 407FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1By similarity)
Gene namesi
Name:sdhA
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

  • Cell inner membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586551 – 600Succinate dehydrogenase flavoprotein subunitAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PRIDEiQ59661

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ59661
SMRiQ59661
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C00 Bacteria
COG1053 LUCA

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q59661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAYKYETHE YDVVVVGAGG AGLRATLGMA EQGLRTACVT KVFPTRSHTV
60 70 80 90 100
AAQGGIAASL SNMGPDNWQW HMYDTVKGSD WLGDTDAMEY LAREAPKAVY
110 120 130 140 150
ELEHYGVPFS RTEEGKIYQR PFGGHTTEFG EGPPVQRTCA AADRTGHAIL
160 170 180 190 200
HTLYGQSLKE KAEFFIEYFA LDLIITDGAC TGVVCWKLDD GTIHVFNAKM
210 220 230 240 250
VVLATGGYGR AYFSATSAHT CTGDGGGMVA RAGLPLQDME FVQFHPTGIY
260 270 280 290 300
GSGCLITEGA RGEGGYLTNS EGERFMERYA PTYKDLASRD VVSRCITIEI
310 320 330 340 350
REGRGVGPHK DHMHLNLMHL PPESLAERLP GISESAKIFA GVDVTREPIP
360 370 380 390 400
ILPTVHYNMG GIPTNYWGEV LNPTQDNPDQ VFPGLMAVGE AGCASVHGAN
410 420 430 440 450
RLGSNSLIDL VVFGRAAAIR AGQVIDREAQ IPTTNKEQVD KALDRFDRIR
460 470 480 490 500
NADGSVSTAD LRLEMQRTMQ ADAAVFRTDK TLAEGVDKMR VIAGKLSDLK
510 520 530 540 550
VTDRSLIWNS DLMETLELTN LMPNALATIV AAEARKESRG AHAHEDYPER
560 570 580 590 600
DDANWRKHSL AWIEGNDVKL AYRPVHLEPL TRQDEGGIDL KKIAPKARVY
Length:600
Mass (Da):65,616
Last modified:November 1, 1996 - v1
Checksum:iE8446E4FB6D8F829
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31902 Genomic DNA Translation: AAA75177.1
PIRiT46880
RefSeqiWP_011746914.1, NZ_FOYK01000010.1

Similar proteinsi

Entry informationi

Entry nameiSDHA_PARDE
AccessioniPrimary (citable) accession number: Q59661
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health