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Q59661

- SDHA_PARDE

UniProt

Q59661 - SDHA_PARDE

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Protein

Succinate dehydrogenase flavoprotein subunit

Gene
sdhA
Organism
Paracoccus denitrificans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241FAD By similarity
Binding sitei245 – 2451Substrate By similarity
Binding sitei257 – 2571Substrate By similarity
Active sitei289 – 2891Proton acceptor By similarity
Binding sitei356 – 3561Substrate By similarity
Binding sitei390 – 3901FAD By similarity
Binding sitei401 – 4011Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 226FAD By similarity
Nucleotide bindingi40 – 5516FAD By similarityAdd
BLAST
Nucleotide bindingi406 – 4072FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01005.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
Gene namesi
Name:sdhA
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Succinate dehydrogenase flavoprotein subunitPRO_0000158655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481Tele-8alpha-FAD histidine By similarity

Proteomic databases

PRIDEiQ59661.

Interactioni

Subunit structurei

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Structurei

3D structure databases

ProteinModelPortaliQ59661.
SMRiQ59661. Positions 4-584.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59661-1 [UniParc]FASTAAdd to Basket

« Hide

MAAYKYETHE YDVVVVGAGG AGLRATLGMA EQGLRTACVT KVFPTRSHTV    50
AAQGGIAASL SNMGPDNWQW HMYDTVKGSD WLGDTDAMEY LAREAPKAVY 100
ELEHYGVPFS RTEEGKIYQR PFGGHTTEFG EGPPVQRTCA AADRTGHAIL 150
HTLYGQSLKE KAEFFIEYFA LDLIITDGAC TGVVCWKLDD GTIHVFNAKM 200
VVLATGGYGR AYFSATSAHT CTGDGGGMVA RAGLPLQDME FVQFHPTGIY 250
GSGCLITEGA RGEGGYLTNS EGERFMERYA PTYKDLASRD VVSRCITIEI 300
REGRGVGPHK DHMHLNLMHL PPESLAERLP GISESAKIFA GVDVTREPIP 350
ILPTVHYNMG GIPTNYWGEV LNPTQDNPDQ VFPGLMAVGE AGCASVHGAN 400
RLGSNSLIDL VVFGRAAAIR AGQVIDREAQ IPTTNKEQVD KALDRFDRIR 450
NADGSVSTAD LRLEMQRTMQ ADAAVFRTDK TLAEGVDKMR VIAGKLSDLK 500
VTDRSLIWNS DLMETLELTN LMPNALATIV AAEARKESRG AHAHEDYPER 550
DDANWRKHSL AWIEGNDVKL AYRPVHLEPL TRQDEGGIDL KKIAPKARVY 600
Length:600
Mass (Da):65,616
Last modified:November 1, 1996 - v1
Checksum:iE8446E4FB6D8F829
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31902 Genomic DNA. Translation: AAA75177.1.
PIRiT46880.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31902 Genomic DNA. Translation: AAA75177.1 .
PIRi T46880.

3D structure databases

ProteinModelPortali Q59661.
SMRi Q59661. Positions 4-584.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q59661.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01005 .

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing, and expression of the succinate-ubiquinone oxidoreductase (SdhCDAB) operon from Paracoccus denitrificans."
    Dickins M.A., Dhawan T., Gunsalus R.P., Schroeder I., Cecchini G.
    Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13543 / NRRL B-3784 / NRC 449.

Entry informationi

Entry nameiSDHA_PARDE
AccessioniPrimary (citable) accession number: Q59661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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