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Q59661 (SDHA_PARDE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase flavoprotein subunit

EC=1.3.5.1
Gene names
Name:sdhA
OrganismParacoccus denitrificans
Taxonomic identifier266 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

FAD.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.

Subunit structure

Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

Subcellular location

Cell inner membrane; Peripheral membrane protein; Cytoplasmic side.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Succinate dehydrogenase flavoprotein subunit
PRO_0000158655

Regions

Nucleotide binding17 – 226FAD By similarity
Nucleotide binding40 – 5516FAD By similarity
Nucleotide binding406 – 4072FAD By similarity

Sites

Active site2891Proton acceptor By similarity
Binding site2241FAD By similarity
Binding site2451Substrate By similarity
Binding site2571Substrate By similarity
Binding site3561Substrate By similarity
Binding site3901FAD By similarity
Binding site4011Substrate By similarity

Amino acid modifications

Modified residue481Tele-8alpha-FAD histidine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59661 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E8446E4FB6D8F829

FASTA60065,616
        10         20         30         40         50         60 
MAAYKYETHE YDVVVVGAGG AGLRATLGMA EQGLRTACVT KVFPTRSHTV AAQGGIAASL 

        70         80         90        100        110        120 
SNMGPDNWQW HMYDTVKGSD WLGDTDAMEY LAREAPKAVY ELEHYGVPFS RTEEGKIYQR 

       130        140        150        160        170        180 
PFGGHTTEFG EGPPVQRTCA AADRTGHAIL HTLYGQSLKE KAEFFIEYFA LDLIITDGAC 

       190        200        210        220        230        240 
TGVVCWKLDD GTIHVFNAKM VVLATGGYGR AYFSATSAHT CTGDGGGMVA RAGLPLQDME 

       250        260        270        280        290        300 
FVQFHPTGIY GSGCLITEGA RGEGGYLTNS EGERFMERYA PTYKDLASRD VVSRCITIEI 

       310        320        330        340        350        360 
REGRGVGPHK DHMHLNLMHL PPESLAERLP GISESAKIFA GVDVTREPIP ILPTVHYNMG 

       370        380        390        400        410        420 
GIPTNYWGEV LNPTQDNPDQ VFPGLMAVGE AGCASVHGAN RLGSNSLIDL VVFGRAAAIR 

       430        440        450        460        470        480 
AGQVIDREAQ IPTTNKEQVD KALDRFDRIR NADGSVSTAD LRLEMQRTMQ ADAAVFRTDK 

       490        500        510        520        530        540 
TLAEGVDKMR VIAGKLSDLK VTDRSLIWNS DLMETLELTN LMPNALATIV AAEARKESRG 

       550        560        570        580        590        600 
AHAHEDYPER DDANWRKHSL AWIEGNDVKL AYRPVHLEPL TRQDEGGIDL KKIAPKARVY 

« Hide

References

[1]"Cloning, sequencing, and expression of the succinate-ubiquinone oxidoreductase (SdhCDAB) operon from Paracoccus denitrificans."
Dickins M.A., Dhawan T., Gunsalus R.P., Schroeder I., Cecchini G.
Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 13543 / NRRL B-3784 / NRC 449.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31902 Genomic DNA. Translation: AAA75177.1.
PIRT46880.

3D structure databases

ProteinModelPortalQ59661.
SMRQ59661. Positions 4-584.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ59661.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00223; UER01005.

Family and domain databases

Gene3D1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHA_PARDE
AccessionPrimary (citable) accession number: Q59661
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways