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Q59661

- SDHA_PARDE

UniProt

Q59661 - SDHA_PARDE

Protein

Succinate dehydrogenase flavoprotein subunit

Gene

sdhA

Organism
Paracoccus denitrificans
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei224 – 2241FADBy similarity
    Binding sitei245 – 2451SubstrateBy similarity
    Binding sitei257 – 2571SubstrateBy similarity
    Active sitei289 – 2891Proton acceptorBy similarity
    Binding sitei356 – 3561SubstrateBy similarity
    Binding sitei390 – 3901FADBy similarity
    Binding sitei401 – 4011SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 226FADBy similarity
    Nucleotide bindingi40 – 5516FADBy similarityAdd
    BLAST
    Nucleotide bindingi406 – 4072FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase flavoprotein subunit (EC:1.3.5.1)
    Gene namesi
    Name:sdhA
    OrganismiParacoccus denitrificans
    Taxonomic identifieri266 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Succinate dehydrogenase flavoprotein subunitPRO_0000158655Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei48 – 481Tele-8alpha-FAD histidineBy similarity

    Proteomic databases

    PRIDEiQ59661.

    Interactioni

    Subunit structurei

    Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur, cytochrome b-556, and a hydrophobic anchor protein.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59661.
    SMRiQ59661. Positions 4-584.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59661-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAYKYETHE YDVVVVGAGG AGLRATLGMA EQGLRTACVT KVFPTRSHTV    50
    AAQGGIAASL SNMGPDNWQW HMYDTVKGSD WLGDTDAMEY LAREAPKAVY 100
    ELEHYGVPFS RTEEGKIYQR PFGGHTTEFG EGPPVQRTCA AADRTGHAIL 150
    HTLYGQSLKE KAEFFIEYFA LDLIITDGAC TGVVCWKLDD GTIHVFNAKM 200
    VVLATGGYGR AYFSATSAHT CTGDGGGMVA RAGLPLQDME FVQFHPTGIY 250
    GSGCLITEGA RGEGGYLTNS EGERFMERYA PTYKDLASRD VVSRCITIEI 300
    REGRGVGPHK DHMHLNLMHL PPESLAERLP GISESAKIFA GVDVTREPIP 350
    ILPTVHYNMG GIPTNYWGEV LNPTQDNPDQ VFPGLMAVGE AGCASVHGAN 400
    RLGSNSLIDL VVFGRAAAIR AGQVIDREAQ IPTTNKEQVD KALDRFDRIR 450
    NADGSVSTAD LRLEMQRTMQ ADAAVFRTDK TLAEGVDKMR VIAGKLSDLK 500
    VTDRSLIWNS DLMETLELTN LMPNALATIV AAEARKESRG AHAHEDYPER 550
    DDANWRKHSL AWIEGNDVKL AYRPVHLEPL TRQDEGGIDL KKIAPKARVY 600
    Length:600
    Mass (Da):65,616
    Last modified:November 1, 1996 - v1
    Checksum:iE8446E4FB6D8F829
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31902 Genomic DNA. Translation: AAA75177.1.
    PIRiT46880.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31902 Genomic DNA. Translation: AAA75177.1 .
    PIRi T46880.

    3D structure databases

    ProteinModelPortali Q59661.
    SMRi Q59661. Positions 4-584.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q59661.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01005 .

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing, and expression of the succinate-ubiquinone oxidoreductase (SdhCDAB) operon from Paracoccus denitrificans."
      Dickins M.A., Dhawan T., Gunsalus R.P., Schroeder I., Cecchini G.
      Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13543 / NRRL B-3784 / NRC 449.

    Entry informationi

    Entry nameiSDHA_PARDE
    AccessioniPrimary (citable) accession number: Q59661
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3