ID   TRPF_PSEAE              Reviewed;         211 AA.
AC   Q59649;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 129.
DE   RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
GN   Name=trpF; OrderedLocusNames=PA3113;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1;
RX   PubMed=8867605; DOI=10.1111/j.1348-0421.1996.tb03324.x;
RA   Murata T.;
RT   "The trpF nucleotide sequence and its promoter analysis in Pseudomonas
RT   aeruginosa.";
RL   Microbiol. Immunol. 40:107-114(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
CC   -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000305}.
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DR   EMBL; D83654; BAA12028.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG06501.1; -; Genomic_DNA.
DR   PIR; D83257; D83257.
DR   RefSeq; NP_251803.1; NC_002516.2.
DR   RefSeq; WP_003104200.1; NZ_QZGE01000023.1.
DR   AlphaFoldDB; Q59649; -.
DR   SMR; Q59649; -.
DR   STRING; 208964.PA3113; -.
DR   PaxDb; 208964-PA3113; -.
DR   GeneID; 877681; -.
DR   KEGG; pae:PA3113; -.
DR   PATRIC; fig|208964.12.peg.3265; -.
DR   PseudoCAP; PA3113; -.
DR   HOGENOM; CLU_076364_2_0_6; -.
DR   InParanoid; Q59649; -.
DR   OrthoDB; 9796196at2; -.
DR   PhylomeDB; Q59649; -.
DR   BioCyc; PAER208964:G1FZ6-3169-MONOMER; -.
DR   UniPathway; UPA00035; UER00042.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IBA:GO_Central.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IBA:GO_Central.
DR   CDD; cd00405; PRAI; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   HAMAP; MF_00135; PRAI; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001240; PRAI_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   InterPro; IPR044643; TrpF_fam.
DR   PANTHER; PTHR42894; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR   PANTHER; PTHR42894:SF1; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR   Pfam; PF00697; PRAI; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Isomerase;
KW   Reference proteome; Tryptophan biosynthesis.
FT   CHAIN           1..211
FT                   /note="N-(5'-phosphoribosyl)anthranilate isomerase"
FT                   /id="PRO_0000154369"
SQ   SEQUENCE   211 AA;  22299 MW;  CD88FDAF865D421B CRC64;
     MPAVRIKICG ITRVEDALAA AAAGADAIGL VFYAKSPRAV DIHRAREIVR ALPPFVTSVG
     LFVNASRCEL GEILDAVPLD LLQFHGDERA EDCEGHRRPY LKALRMKPGD DIVGRAAAYP
     GAAGILLDTY VEGVPGGTGA AFDWSLVPTD LGKPLVLAGG LTPDNVGRAV EQVKPYAVDV
     SGGVEASKGI KDAARVRAFV DAVRSRRRDE T
//