Q59646 (NORC_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nitric oxide reductase subunit C

Alternative name(s):
NOR small subunit
Nitric oxide reductase cytochrome c subunit

Gene names

Name:	norC
Ordered Locus Names:	PA0523

Organism

Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

Taxonomic identifier

208964 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the anaerobic respiratory chain that transforms nitrate to dinitrogen (denitrification).
Subunit structure	Heterodimer of cytochromes b (large subunit) and c (small subunit).
Subcellular location	Cell membrane; Single-pass membrane protein. Note: May be attached to the membrane by a signal-anchor.
Induction	By nitric oxide Probable.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Heme Iron Metal-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 146

145

Nitric oxide reductase subunit C

PRO_0000108424

Regions

Transmembrane

13 – 29

17

Helical; Signal-anchor; Potential

Sites

Metal binding

65

1

Iron (heme axial ligand) By similarity

Binding site

61

1

Heme (covalent) By similarity

Binding site

64

1

Heme (covalent) By similarity

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

146

Helix Strand Turn

Details...

Helix

10 – 14

5

Helix

19 – 33

15

Helix

36 – 39

4

Helix

42 – 44

3

Helix

47 – 50

4

Helix

54 – 59

6

Helix

92 – 101

10

Helix

122 – 132

11

Beta strand

141 – 143

3

Sequences

	Sequence		Length	Mass (Da)
	Q59646 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 1C0DB7E59431CC98	FASTA	146	16,344
	10 20 30 40 50 60 MSETFTKGMA RNIYFGGSVF FILLFLALTY HTEKTLPERT NEAAMSAAVV RGKLVWEQNN 70 80 90 100 110 120 CVGCHTLLGE GAYFAPELGN VVGRRGGEEG FNTFLQAWMN IQPLNVPGRR AMPQFHLSEG 130 140 QVDDLAEFLK WSSKIDTNQW PPNKEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The structural genes for nitric oxide reductase from Pseudomonas aeruginosa." Arai H., Igarashi Y., Kodama T. Biochim. Biophys. Acta 1261:279-284(1995) [PubMed: 7711073] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D38133 Genomic DNA. Translation: BAA07329.1.
AE004091 Genomic DNA. Translation: AAG03912.1.

PIR

S53712.

RefSeq

NP_249214.1. NC_002516.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3O0R	X-ray	2.70	C	1-146	[»]

ProteinModelPortal

Q59646.

ModBase

Search...

Proteomic databases

PRIDE

Q59646.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

882200.

GenomeReviews

Gene locus PA0523 in contig AE004091_GR.

KEGG

pae:PA0523.

NMPDR

fig|208964.1.peg.524.

PATRIC

19835304. VBIPseAer58763_0553.

Organism-specific databases

PseudoCAP

PA0523.

Phylogenomic databases

HOGENOM

HBG353826.

OMA

QMPQFNL.

ProtClustDB

CLSK865919.

Enzyme and pathway databases

BioCyc

PAER208964:PA0523-MONOMER.

Family and domain databases

InterPro

IPR009056. Cyt_c_dom.
IPR003088. Cyt_c_I.
[Graphical view]

Gene3D

G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.

KO

K02305.

Pfam

PF00034. Cytochrom_C. 1 hit.
[Graphical view]

SUPFAM

SSF46626. Cytochrome_c. 1 hit.

PROSITE

PS51007. CYTC. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

NORC_PSEAE

Accession

Primary (citable) accession number: Q59646

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 89 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program