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Reviewed, UniProtKB/Swiss-Prot Q59642 (LDHD_PEDAC)

Last modified June 16, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    D-lactate dehydrogenase
      Short name=D-LDH
    EC=1.1.1.28
Alternative name(s):
    D-specific D-2-hydroxyacid dehydrogenase
Gene names
Name: ldhD
OrganismPediococcus acidilactici
Taxonomic identifier1254 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLactobacillaceaePediococcus

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Has both D-lactate and D-glycerate dehydrogenase activities. Equally active on pyruvate and hydroxypyruvate.

Catalytic activity

(R)-lactate + NAD+ = pyruvate + NADH.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionD-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

NAD or NADH binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331D-lactate dehydrogenase
PRO_0000075958

Sites

Active site2341 By similarity
Active site2631 By similarity
Active site2951Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59642-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C2E6653EC661AEB8

FASTA33137,210
        10         20         30         40         50         60 
MKIIAYGIRD DEKPYLDEWV TKNHIEVKAV PDLLDSSNID LAKDYDGVVA YQQKPYTADL 

        70         80         90        100        110        120 
FDKMHEFGIH AFSLRNVGLD NVPADALKKN DIKISNVPAY SPRAIAELSV TQLLALLRKI 

       130        140        150        160        170        180 
PEFEYKMAHG DYRWEPDIGL ELNQMTVGVI GTGRIGRAAI DIFKPFGAKV IAYDVFRNPA 

       190        200        210        220        230        240 
LEKEGMYVDT LEELYQQANV ITLHVPALKD NYHMLDEKAF GQMQDGTFIL NFARGTLVDT 

       250        260        270        280        290        300 
PALLKALDSG KVAGAALDTY ENEVGIFDVD HGDQPIDDPV FNDLMSRRNV MITPHAAFYT 

       310        320        330 
RPAVKNMVQI ALDNNRDLIE KNSSKNEVKF E 

« Hide

References

[1]"Pediococcus acidilactici ldhD gene: cloning, nucleotide sequence, and transcriptional analysis."
Garmyn D., Ferain T., Bernard N., Hols P., Delplace B., Delcour J.
J. Bacteriol. 177:3427-3437(1995) [PubMed: 7539419] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DG302.

Cross-references

Sequence databases

X70925 Genomic DNA. Translation: CAA50275.1.

3D structure databases

HSSPHSSP built from PDB template 2DLD based on UniProtKB P30901.
ModBaseSearch...

Enzyme and pathway databases

BRENDA1.1.1.28. 1193.

Family and domain databases

InterProIPR006139. D-isomer_2_OHA_DH.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00065. D_2_HYDROXYACID_DH_1. 1 hit.
PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDHD_PEDAC
AccessionPrimary (citable) accession number: Q59642
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents