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Q59640

- CDSA_PSEAE

UniProt

Q59640 - CDSA_PSEAE

Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (08 Dec 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    Short name:
    CDS
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CTP:phosphatidate cytidylyltransferase
    Gene namesi
    Name:cdsA
    Synonyms:cds
    Ordered Locus Names:PA3651
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA3651.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Phosphatidate cytidylyltransferasePRO_0000090744Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA3651.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59640.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    HOGENOMiHOG000006168.
    KOiK00981.
    OMAiHYSGALW.
    OrthoDBiEOG6TBHJT.
    PhylomeDBiQ59640.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59640-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKQRIITAL VLLPIALGGF FLLEGAFFAL FIGAVVSLGA WEWARLAGYE    50
    QQFGRVAYAA TVAVLMVALY HLPQLAGAVL LLALVWWTLA TVLVLTYPES 100
    VGYWGGRWRR LGMGLLILLP AWQGLVLLKQ WPLANGLIIA VMVLVWGADI 150
    GAYFSGKAFG KRKLAPRVSP GKSWEGVYGG LAASLAITLA VGLYRGWSLG 200
    ALLLALLGAA LVVFVSIVGD LTESMFKRQS GIKDSSNLLP GHGGVLDRID 250
    SLTAAIPVFA ALLWAAGWGA P 271
    Length:271
    Mass (Da):28,856
    Last modified:December 8, 2000 - v2
    Checksum:i5025059C3F1A64C7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti131 – 1333WPL → VAA in BAA09437. (PubMed:8654980)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50811 Genomic DNA. Translation: BAA09437.1.
    AE004091 Genomic DNA. Translation: AAG07039.1.
    PIRiF83188.
    JC4832.
    RefSeqiNP_252341.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG07039; AAG07039; PA3651.
    GeneIDi880465.
    KEGGipae:PA3651.
    PATRICi19841925. VBIPseAer58763_3820.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50811 Genomic DNA. Translation: BAA09437.1 .
    AE004091 Genomic DNA. Translation: AAG07039.1 .
    PIRi F83188.
    JC4832.
    RefSeqi NP_252341.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q59640.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA3651.

    Protocols and materials databases

    DNASUi 880465.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG07039 ; AAG07039 ; PA3651 .
    GeneIDi 880465.
    KEGGi pae:PA3651.
    PATRICi 19841925. VBIPseAer58763_3820.

    Organism-specific databases

    PseudoCAPi PA3651.

    Phylogenomic databases

    eggNOGi COG0575.
    HOGENOMi HOG000006168.
    KOi K00981.
    OMAi HYSGALW.
    OrthoDBi EOG6TBHJT.
    PhylomeDBi Q59640.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .

    Family and domain databases

    InterProi IPR000374. PC_trans.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the Pseudomonas aeruginosa gene encoding CDP-diglyceride synthetase."
      Taguchi K., Fukutomi H., Kuroda A., Kato J., Ohtake H.
      Gene 172:165-166(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiCDSA_PSEAE
    AccessioniPrimary (citable) accession number: Q59640
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 8, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3