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Q59640

- CDSA_PSEAE

UniProt

Q59640 - CDSA_PSEAE

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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Synonyms:cds
Ordered Locus Names:PA3651
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA3651.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Phosphatidate cytidylyltransferasePRO_0000090744Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3651.

Structurei

3D structure databases

ProteinModelPortaliQ59640.
SMRiQ59640. Positions 2-258.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000006168.
InParanoidiQ59640.
KOiK00981.
OMAiHYSGALW.
OrthoDBiEOG6TBHJT.
PhylomeDBiQ59640.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59640-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKQRIITAL VLLPIALGGF FLLEGAFFAL FIGAVVSLGA WEWARLAGYE
60 70 80 90 100
QQFGRVAYAA TVAVLMVALY HLPQLAGAVL LLALVWWTLA TVLVLTYPES
110 120 130 140 150
VGYWGGRWRR LGMGLLILLP AWQGLVLLKQ WPLANGLIIA VMVLVWGADI
160 170 180 190 200
GAYFSGKAFG KRKLAPRVSP GKSWEGVYGG LAASLAITLA VGLYRGWSLG
210 220 230 240 250
ALLLALLGAA LVVFVSIVGD LTESMFKRQS GIKDSSNLLP GHGGVLDRID
260 270
SLTAAIPVFA ALLWAAGWGA P
Length:271
Mass (Da):28,856
Last modified:December 8, 2000 - v2
Checksum:i5025059C3F1A64C7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1333WPL → VAA in BAA09437. (PubMed:8654980)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50811 Genomic DNA. Translation: BAA09437.1.
AE004091 Genomic DNA. Translation: AAG07039.1.
PIRiF83188.
JC4832.
RefSeqiNP_252341.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG07039; AAG07039; PA3651.
GeneIDi880465.
KEGGipae:PA3651.
PATRICi19841925. VBIPseAer58763_3820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50811 Genomic DNA. Translation: BAA09437.1 .
AE004091 Genomic DNA. Translation: AAG07039.1 .
PIRi F83188.
JC4832.
RefSeqi NP_252341.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q59640.
SMRi Q59640. Positions 2-258.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA3651.

Protocols and materials databases

DNASUi 880465.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG07039 ; AAG07039 ; PA3651 .
GeneIDi 880465.
KEGGi pae:PA3651.
PATRICi 19841925. VBIPseAer58763_3820.

Organism-specific databases

PseudoCAPi PA3651.

Phylogenomic databases

eggNOGi COG0575.
HOGENOMi HOG000006168.
InParanoidi Q59640.
KOi K00981.
OMAi HYSGALW.
OrthoDBi EOG6TBHJT.
PhylomeDBi Q59640.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .

Family and domain databases

InterProi IPR000374. PC_trans.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the Pseudomonas aeruginosa gene encoding CDP-diglyceride synthetase."
    Taguchi K., Fukutomi H., Kuroda A., Kato J., Ohtake H.
    Gene 172:165-166(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiCDSA_PSEAE
AccessioniPrimary (citable) accession number: Q59640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 8, 2000
Last modified: October 29, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3