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Q59637

- ODP1_PSEAE

UniProt

Q59637 - ODP1_PSEAE

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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
Short name:
PDH E1 component
Gene namesi
Name:aceE
Synonyms:aceA
Ordered Locus Names:PA5015
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA5015.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 882882Pyruvate dehydrogenase E1 componentPRO_0000162247Add
BLAST

Proteomic databases

PRIDEiQ59637.

Interactioni

Subunit structurei

Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

Protein-protein interaction databases

STRINGi208964.PA5015.

Structurei

3D structure databases

ProteinModelPortaliQ59637.
SMRiQ59637. Positions 54-879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
HOGENOMiHOG000115215.
InParanoidiQ59637.
KOiK00163.
OMAiKGIYKLD.
OrthoDBiEOG6BW4TW.
PhylomeDBiQ59637.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 2 hits.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59637-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDLDPVETQ EWLDALESVL DREGEDRAHY LMTRMGELAS RSGTQLPYAI
60 70 80 90 100
TTPYRNTIPV THEARMPGDL FMERRIRSLV RWNALAMVMR ANKHDPDLGG
110 120 130 140 150
HISTFASSAT LYDIGFNYFF QAPTDEHGGD LVFFQGHASP GVYARAFLEG
160 170 180 190 200
RISEEQLENF RQEVDGNGLS SYPHPWLMPD FWQFPTVSMG LGPIQAIYQA
210 220 230 240 250
RFMKYLESRG FIPAGKQKVW CFMGDGECDE PESLGAISLA GREKLDNLIF
260 270 280 290 300
VINCNLQRLD GPVRGNAKII QELEGVFRGA EWNVNKVIWG RFWDPLFAKD
310 320 330 340 350
TAGLLQQRMD EVIDGEYQNY KAKDGAYVRE HFFGARPELL EMVKDLSDEE
360 370 380 390 400
IWKLNRGGHD PYKVYAAYHQ AVNHKGQPTV ILAKTIKGYG TGSGEAKNIA
410 420 430 440 450
HNVKKVDVDS LRAFRDKFDI PVKDADLEKL PFYKPEEGSA EAKYLAERRA
460 470 480 490 500
ALGGFMPVRR QKSMSVPVPP LETLKAMLDG SGDREISTTM AFVRIISQLV
510 520 530 540 550
KDKELGPRIV PIVPDEARTF GMEGMFRQLG IYSSVGQLYE PVDKDQVMFY
560 570 580 590 600
REDKKGQILE EGINEAGAMS SWIAAGTSYS THNQPMLPFY IFYSMFGFQR
610 620 630 640 650
IGDLAWAAGD SRAHGFLIGG TAGRTTLNGE GLQHEDGHSH LLASTIPNCR
660 670 680 690 700
TYDPTYAYEL AVIIREGSRQ MIEEQQDIFY YITVMNENYV QPAMPKGAEE
710 720 730 740 750
GIIKGMYLLE EDKKEAAHHV QLLGSGTILR EVEEAAKLLR NDFGIGADVW
760 770 780 790 800
SVPSFNELRR DGLAVERWNR LHPGQKPKQS YVEECLGGRR GPVIASTDYM
810 820 830 840 850
KLYAEQIRQW VPSKEYKVLG TDGFGRSDSR KKLRNFFEVD RHWVVLAALE
860 870 880
ALADRGDIEP KVVAEAIAKY GIDPEKRNPL DC
Length:882
Mass (Da):99,564
Last modified:January 11, 2001 - v2
Checksum:i5FD387B8332E24D9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 783IRS → DPLP in AAC45353. (PubMed:9171401)Curated
Sequence conflicti149 – 1568EGRISEEQ → GRPHQRRNK in AAC45353. (PubMed:9171401)Curated
Sequence conflicti167 – 1748NGLSSYPH → TACPPIRT in AAC45353. (PubMed:9171401)Curated
Sequence conflicti377 – 3771Q → H in AAC45353. (PubMed:9171401)Curated
Sequence conflicti388 – 3881G → V in AAC45353. (PubMed:9171401)Curated
Sequence conflicti392 – 3921G → A in AAC45353. (PubMed:9171401)Curated
Sequence conflicti408 – 4092Missing in AAC45353. (PubMed:9171401)Curated
Sequence conflicti517 – 5171A → G in AAC45353. (PubMed:9171401)Curated
Sequence conflicti671 – 6711Missing in AAC45353. (PubMed:9171401)Curated
Sequence conflicti740 – 7401R → H in AAC45353. (PubMed:9171401)Curated
Sequence conflicti744 – 7463GIG → DIV in AAC45353. (PubMed:9171401)Curated
Sequence conflicti760 – 7656RDGLAV → HDDLTL in AAC45353. (PubMed:9171401)Curated
Sequence conflicti788 – 7914GRRG → APSR in AAC45353. (PubMed:9171401)Curated
Sequence conflicti821 – 8211Missing in AAC45353. (PubMed:9171401)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47920 Genomic DNA. Translation: AAC45353.1.
AE004091 Genomic DNA. Translation: AAG08400.1.
PIRiG83018.
RefSeqiNP_253702.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08400; AAG08400; PA5015.
GeneIDi881326.
KEGGipae:PA5015.
PATRICi19844853. VBIPseAer58763_5255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47920 Genomic DNA. Translation: AAC45353.1 .
AE004091 Genomic DNA. Translation: AAG08400.1 .
PIRi G83018.
RefSeqi NP_253702.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q59637.
SMRi Q59637. Positions 54-879.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA5015.

Proteomic databases

PRIDEi Q59637.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08400 ; AAG08400 ; PA5015 .
GeneIDi 881326.
KEGGi pae:PA5015.
PATRICi 19844853. VBIPseAer58763_5255.

Organism-specific databases

PseudoCAPi PA5015.

Phylogenomic databases

eggNOGi COG2609.
HOGENOMi HOG000115215.
InParanoidi Q59637.
KOi K00163.
OMAi KGIYKLD.
OrthoDBi EOG6BW4TW.
PhylomeDBi Q59637.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF00456. Transketolase_N. 2 hits.
[Graphical view ]
PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00759. aceE. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and expression of pyruvate dehydrogenase genes from Pseudomonas aeruginosa."
    Rae J.L., Cutfield J.F., Lamont I.L.
    J. Bacteriol. 179:3561-3571(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PAO.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiODP1_PSEAE
AccessioniPrimary (citable) accession number: Q59637
Secondary accession number(s): Q9HUF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: November 26, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3