Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q59637

- ODP1_PSEAE

UniProt

Q59637 - ODP1_PSEAE

Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component (EC:1.2.4.1)
    Short name:
    PDH E1 component
    Gene namesi
    Name:aceE
    Synonyms:aceA
    Ordered Locus Names:PA5015
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA5015.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 882882Pyruvate dehydrogenase E1 componentPRO_0000162247Add
    BLAST

    Proteomic databases

    PRIDEiQ59637.

    Interactioni

    Subunit structurei

    Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).By similarity

    Protein-protein interaction databases

    STRINGi208964.PA5015.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59637.
    SMRiQ59637. Positions 54-879.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2609.
    HOGENOMiHOG000115215.
    KOiK00163.
    OMAiKGIYKLD.
    OrthoDBiEOG6BW4TW.
    PhylomeDBiQ59637.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProiIPR004660. 2-oxoA_DH_E1.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF00456. Transketolase_N. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00759. aceE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59637-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQDLDPVETQ EWLDALESVL DREGEDRAHY LMTRMGELAS RSGTQLPYAI    50
    TTPYRNTIPV THEARMPGDL FMERRIRSLV RWNALAMVMR ANKHDPDLGG 100
    HISTFASSAT LYDIGFNYFF QAPTDEHGGD LVFFQGHASP GVYARAFLEG 150
    RISEEQLENF RQEVDGNGLS SYPHPWLMPD FWQFPTVSMG LGPIQAIYQA 200
    RFMKYLESRG FIPAGKQKVW CFMGDGECDE PESLGAISLA GREKLDNLIF 250
    VINCNLQRLD GPVRGNAKII QELEGVFRGA EWNVNKVIWG RFWDPLFAKD 300
    TAGLLQQRMD EVIDGEYQNY KAKDGAYVRE HFFGARPELL EMVKDLSDEE 350
    IWKLNRGGHD PYKVYAAYHQ AVNHKGQPTV ILAKTIKGYG TGSGEAKNIA 400
    HNVKKVDVDS LRAFRDKFDI PVKDADLEKL PFYKPEEGSA EAKYLAERRA 450
    ALGGFMPVRR QKSMSVPVPP LETLKAMLDG SGDREISTTM AFVRIISQLV 500
    KDKELGPRIV PIVPDEARTF GMEGMFRQLG IYSSVGQLYE PVDKDQVMFY 550
    REDKKGQILE EGINEAGAMS SWIAAGTSYS THNQPMLPFY IFYSMFGFQR 600
    IGDLAWAAGD SRAHGFLIGG TAGRTTLNGE GLQHEDGHSH LLASTIPNCR 650
    TYDPTYAYEL AVIIREGSRQ MIEEQQDIFY YITVMNENYV QPAMPKGAEE 700
    GIIKGMYLLE EDKKEAAHHV QLLGSGTILR EVEEAAKLLR NDFGIGADVW 750
    SVPSFNELRR DGLAVERWNR LHPGQKPKQS YVEECLGGRR GPVIASTDYM 800
    KLYAEQIRQW VPSKEYKVLG TDGFGRSDSR KKLRNFFEVD RHWVVLAALE 850
    ALADRGDIEP KVVAEAIAKY GIDPEKRNPL DC 882
    Length:882
    Mass (Da):99,564
    Last modified:January 11, 2001 - v2
    Checksum:i5FD387B8332E24D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti76 – 783IRS → DPLP in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti149 – 1568EGRISEEQ → GRPHQRRNK in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti167 – 1748NGLSSYPH → TACPPIRT in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti377 – 3771Q → H in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti388 – 3881G → V in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti392 – 3921G → A in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti408 – 4092Missing in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti517 – 5171A → G in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti671 – 6711Missing in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti740 – 7401R → H in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti744 – 7463GIG → DIV in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti760 – 7656RDGLAV → HDDLTL in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti788 – 7914GRRG → APSR in AAC45353. (PubMed:9171401)Curated
    Sequence conflicti821 – 8211Missing in AAC45353. (PubMed:9171401)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47920 Genomic DNA. Translation: AAC45353.1.
    AE004091 Genomic DNA. Translation: AAG08400.1.
    PIRiG83018.
    RefSeqiNP_253702.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG08400; AAG08400; PA5015.
    GeneIDi881326.
    KEGGipae:PA5015.
    PATRICi19844853. VBIPseAer58763_5255.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47920 Genomic DNA. Translation: AAC45353.1 .
    AE004091 Genomic DNA. Translation: AAG08400.1 .
    PIRi G83018.
    RefSeqi NP_253702.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q59637.
    SMRi Q59637. Positions 54-879.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA5015.

    Proteomic databases

    PRIDEi Q59637.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG08400 ; AAG08400 ; PA5015 .
    GeneIDi 881326.
    KEGGi pae:PA5015.
    PATRICi 19844853. VBIPseAer58763_5255.

    Organism-specific databases

    PseudoCAPi PA5015.

    Phylogenomic databases

    eggNOGi COG2609.
    HOGENOMi HOG000115215.
    KOi K00163.
    OMAi KGIYKLD.
    OrthoDBi EOG6BW4TW.
    PhylomeDBi Q59637.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProi IPR004660. 2-oxoA_DH_E1.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF00456. Transketolase_N. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00759. aceE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and expression of pyruvate dehydrogenase genes from Pseudomonas aeruginosa."
      Rae J.L., Cutfield J.F., Lamont I.L.
      J. Bacteriol. 179:3561-3571(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PAO.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiODP1_PSEAE
    AccessioniPrimary (citable) accession number: Q59637
    Secondary accession number(s): Q9HUF3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3