ID   CATB_PSEAE              Reviewed;         513 AA.
AC   Q59635;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 132.
DE   RecName: Full=Catalase;
DE            EC=1.11.1.6;
DE   AltName: Full=Paraquat-inducible catalase isozyme B;
DE   Flags: Precursor;
GN   Name=katB; OrderedLocusNames=PA4613;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FRD2;
RX   PubMed=7592431; DOI=10.1128/jb.177.22.6536-6544.1995;
RA   Brown S.M., Howell M.L., Vasil M.L., Anderson A.J., Hassett D.J.;
RT   "Cloning and characterization of the katB gene of Pseudomonas aeruginosa
RT   encoding a hydrogen peroxide-inducible catalase: purification of KatB,
RT   cellular localization, and demonstration that it is essential for optimal
RT   resistance to hydrogen peroxide.";
RL   J. Bacteriol. 177:6536-6544(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FRD1;
RA   Howell M.L., Heur M., Klotz M.G., Hassett D.J.;
RT   "Pseudomonas aeruginosa oxidative stress operon.";
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Decomposes hydrogen peroxide into water and oxygen; serves to
CC       protect cells from the toxic effects of hydrogen peroxide.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10013};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the catalase family. {ECO:0000305}.
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DR   EMBL; U34896; AAA79046.1; -; Genomic_DNA.
DR   EMBL; U89384; AAB49463.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG08001.1; -; Genomic_DNA.
DR   PIR; E83069; E83069.
DR   RefSeq; NP_253303.1; NC_002516.2.
DR   RefSeq; WP_003094881.1; NZ_QZGE01000004.1.
DR   AlphaFoldDB; Q59635; -.
DR   SMR; Q59635; -.
DR   STRING; 208964.PA4613; -.
DR   PaxDb; 208964-PA4613; -.
DR   GeneID; 881120; -.
DR   KEGG; pae:PA4613; -.
DR   PATRIC; fig|208964.12.peg.4828; -.
DR   PseudoCAP; PA4613; -.
DR   HOGENOM; CLU_010645_2_0_6; -.
DR   InParanoid; Q59635; -.
DR   OrthoDB; 9761719at2; -.
DR   PhylomeDB; Q59635; -.
DR   BioCyc; PAER208964:G1FZ6-4707-MONOMER; -.
DR   SABIO-RK; Q59635; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004096; F:catalase activity; IBA:GO_Central.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR   GO; GO:0042542; P:response to hydrogen peroxide; IBA:GO_Central.
DR   CDD; cd08154; catalase_clade_1; 1.
DR   Gene3D; 2.40.180.10; Catalase core domain; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   PANTHER; PTHR11465; CATALASE; 1.
DR   PANTHER; PTHR11465:SF23; CATALASE-2; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; Heme-dependent catalase-like; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
KW   Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Periplasm;
KW   Peroxidase; Reference proteome; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..513
FT                   /note="Catalase"
FT                   /id="PRO_0000004693"
FT   REGION          391..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        81
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT   ACT_SITE        153
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT   BINDING         361
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   513 AA;  57131 MW;  C9A09B88629A11CB CRC64;
     MNPSLNAFRP GRLLVAASLT ASLLSLSVQA ATLTRDNGAP VGDNQNSQTA GPNGSVLLQD
     VQLLQKLQRF DRERIPERVV HARGTGAHGE FVASADISDL SMAKVFRKGE KTPVFVRFSA
     VVHGNHSPET LRDPRGFATK FYTADGNWDL VGNNFPTFFI RDAIKFPDMV HAFKPDPRSN
     LDDDSRRFDF FSHVPEATRT LTLLYSNEGT PASYREMDGN SVHAYKLVNA RGEVHYVKFH
     WKSLQGQKNL DPKQVAEVQG RDYSHMTNDL VSAIRKGDFP KWDLYIQVLK PEDLAKFDFD
     PLDATKIWPG IPERKIGQMV LNRNVDNFFQ ETEQVAMAPS NLVPGIEPSE DRLLQGRLFA
     YADTQMYRVG ANGLGLPVNR PRSEVNTVNQ DGALNAGHST SGVNYQPSRL DPREEQASAR
     YVRTPLSGTT QQAKIQREQN FKQTGELFRS YGKKDQADLI ASLGGALAIT DDESKYIMLS
     YFYKADSDYG TGLAKVAGAD LQRVRQLAAK LQD
//