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Protein

Catalase

Gene

katB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811PROSITE-ProRule annotation
Active sitei153 – 1531PROSITE-ProRule annotation
Metal bindingi361 – 3611Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
  2. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKQ59635.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Alternative name(s):
Paraquat-inducible catalase isozyme B
Gene namesi
Name:katB
Ordered Locus Names:PA4613
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4613.

Subcellular locationi

Periplasm Curated

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 513483CatalasePRO_0000004693Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4613.

Structurei

3D structure databases

ProteinModelPortaliQ59635.
SMRiQ59635. Positions 32-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0753.
HOGENOMiHOG000087852.
InParanoidiQ59635.
KOiK03781.
OMAiEATTMIM.
OrthoDBiEOG6P5Z9F.
PhylomeDBiQ59635.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59635-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPSLNAFRP GRLLVAASLT ASLLSLSVQA ATLTRDNGAP VGDNQNSQTA
60 70 80 90 100
GPNGSVLLQD VQLLQKLQRF DRERIPERVV HARGTGAHGE FVASADISDL
110 120 130 140 150
SMAKVFRKGE KTPVFVRFSA VVHGNHSPET LRDPRGFATK FYTADGNWDL
160 170 180 190 200
VGNNFPTFFI RDAIKFPDMV HAFKPDPRSN LDDDSRRFDF FSHVPEATRT
210 220 230 240 250
LTLLYSNEGT PASYREMDGN SVHAYKLVNA RGEVHYVKFH WKSLQGQKNL
260 270 280 290 300
DPKQVAEVQG RDYSHMTNDL VSAIRKGDFP KWDLYIQVLK PEDLAKFDFD
310 320 330 340 350
PLDATKIWPG IPERKIGQMV LNRNVDNFFQ ETEQVAMAPS NLVPGIEPSE
360 370 380 390 400
DRLLQGRLFA YADTQMYRVG ANGLGLPVNR PRSEVNTVNQ DGALNAGHST
410 420 430 440 450
SGVNYQPSRL DPREEQASAR YVRTPLSGTT QQAKIQREQN FKQTGELFRS
460 470 480 490 500
YGKKDQADLI ASLGGALAIT DDESKYIMLS YFYKADSDYG TGLAKVAGAD
510
LQRVRQLAAK LQD
Length:513
Mass (Da):57,131
Last modified:October 31, 1996 - v1
Checksum:iC9A09B88629A11CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34896 Genomic DNA. Translation: AAA79046.1.
U89384 Genomic DNA. Translation: AAB49463.1.
AE004091 Genomic DNA. Translation: AAG08001.1.
PIRiE83069.
RefSeqiNP_253303.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08001; AAG08001; PA4613.
GeneIDi881120.
KEGGipae:PA4613.
PATRICi19843973. VBIPseAer58763_4828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34896 Genomic DNA. Translation: AAA79046.1.
U89384 Genomic DNA. Translation: AAB49463.1.
AE004091 Genomic DNA. Translation: AAG08001.1.
PIRiE83069.
RefSeqiNP_253303.1. NC_002516.2.

3D structure databases

ProteinModelPortaliQ59635.
SMRiQ59635. Positions 32-513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG08001; AAG08001; PA4613.
GeneIDi881120.
KEGGipae:PA4613.
PATRICi19843973. VBIPseAer58763_4828.

Organism-specific databases

PseudoCAPiPA4613.

Phylogenomic databases

eggNOGiCOG0753.
HOGENOMiHOG000087852.
InParanoidiQ59635.
KOiK03781.
OMAiEATTMIM.
OrthoDBiEOG6P5Z9F.
PhylomeDBiQ59635.

Enzyme and pathway databases

SABIO-RKQ59635.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: purification of KatB, cellular localization, and demonstration that it is essential for optimal resistance to hydrogen peroxide."
    Brown S.M., Howell M.L., Vasil M.L., Anderson A.J., Hassett D.J.
    J. Bacteriol. 177:6536-6544(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FRD2.
  2. "Pseudomonas aeruginosa oxidative stress operon."
    Howell M.L., Heur M., Klotz M.G., Hassett D.J.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FRD1.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiCATB_PSEAE
AccessioniPrimary (citable) accession number: Q59635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1996
Last modified: March 3, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.