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Q59635

- CATB_PSEAE

UniProt

Q59635 - CATB_PSEAE

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Protein
Catalase
Gene
katB, PA4613
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.

Cofactori

Heme group.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811 By similarity
Active sitei153 – 1531 By similarity
Metal bindingi361 – 3611Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKQ59635.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Alternative name(s):
Paraquat-inducible catalase isozyme B
Gene namesi
Name:katB
Ordered Locus Names:PA4613
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA4613.

Subcellular locationi

Periplasm Inferred

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 513483Catalase
PRO_0000004693Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4613.

Structurei

3D structure databases

ProteinModelPortaliQ59635.
SMRiQ59635. Positions 32-513.

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0753.
HOGENOMiHOG000087852.
KOiK03781.
OMAiDDESKHI.
OrthoDBiEOG6P5Z9F.
PhylomeDBiQ59635.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59635-1 [UniParc]FASTAAdd to Basket

« Hide

MNPSLNAFRP GRLLVAASLT ASLLSLSVQA ATLTRDNGAP VGDNQNSQTA    50
GPNGSVLLQD VQLLQKLQRF DRERIPERVV HARGTGAHGE FVASADISDL 100
SMAKVFRKGE KTPVFVRFSA VVHGNHSPET LRDPRGFATK FYTADGNWDL 150
VGNNFPTFFI RDAIKFPDMV HAFKPDPRSN LDDDSRRFDF FSHVPEATRT 200
LTLLYSNEGT PASYREMDGN SVHAYKLVNA RGEVHYVKFH WKSLQGQKNL 250
DPKQVAEVQG RDYSHMTNDL VSAIRKGDFP KWDLYIQVLK PEDLAKFDFD 300
PLDATKIWPG IPERKIGQMV LNRNVDNFFQ ETEQVAMAPS NLVPGIEPSE 350
DRLLQGRLFA YADTQMYRVG ANGLGLPVNR PRSEVNTVNQ DGALNAGHST 400
SGVNYQPSRL DPREEQASAR YVRTPLSGTT QQAKIQREQN FKQTGELFRS 450
YGKKDQADLI ASLGGALAIT DDESKYIMLS YFYKADSDYG TGLAKVAGAD 500
LQRVRQLAAK LQD 513
Length:513
Mass (Da):57,131
Last modified:November 1, 1996 - v1
Checksum:iC9A09B88629A11CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34896 Genomic DNA. Translation: AAA79046.1.
U89384 Genomic DNA. Translation: AAB49463.1.
AE004091 Genomic DNA. Translation: AAG08001.1.
PIRiE83069.
RefSeqiNP_253303.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG08001; AAG08001; PA4613.
GeneIDi881120.
KEGGipae:PA4613.
PATRICi19843973. VBIPseAer58763_4828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34896 Genomic DNA. Translation: AAA79046.1 .
U89384 Genomic DNA. Translation: AAB49463.1 .
AE004091 Genomic DNA. Translation: AAG08001.1 .
PIRi E83069.
RefSeqi NP_253303.1. NC_002516.2.

3D structure databases

ProteinModelPortali Q59635.
SMRi Q59635. Positions 32-513.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA4613.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG08001 ; AAG08001 ; PA4613 .
GeneIDi 881120.
KEGGi pae:PA4613.
PATRICi 19843973. VBIPseAer58763_4828.

Organism-specific databases

PseudoCAPi PA4613.

Phylogenomic databases

eggNOGi COG0753.
HOGENOMi HOG000087852.
KOi K03781.
OMAi DDESKHI.
OrthoDBi EOG6P5Z9F.
PhylomeDBi Q59635.

Enzyme and pathway databases

SABIO-RK Q59635.

Family and domain databases

Gene3Di 2.40.180.10. 1 hit.
InterProi IPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view ]
PANTHERi PTHR11465. PTHR11465. 1 hit.
Pfami PF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view ]
PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSi PR00067. CATALASE.
SMARTi SM01060. Catalase. 1 hit.
[Graphical view ]
SUPFAMi SSF56634. SSF56634. 1 hit.
PROSITEi PS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: purification of KatB, cellular localization, and demonstration that it is essential for optimal resistance to hydrogen peroxide."
    Brown S.M., Howell M.L., Vasil M.L., Anderson A.J., Hassett D.J.
    J. Bacteriol. 177:6536-6544(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FRD2.
  2. "Pseudomonas aeruginosa oxidative stress operon."
    Howell M.L., Heur M., Klotz M.G., Hassett D.J.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FRD1.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiCATB_PSEAE
AccessioniPrimary (citable) accession number: Q59635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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