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Q59635

- CATB_PSEAE

UniProt

Q59635 - CATB_PSEAE

Protein

Catalase

Gene

katB

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

    Catalytic activityi

    2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

    Cofactori

    Heme group.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei81 – 811PROSITE-ProRule annotation
    Active sitei153 – 1531PROSITE-ProRule annotation
    Metal bindingi361 – 3611Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. catalase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. hydrogen peroxide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Biological processi

    Hydrogen peroxide

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKQ59635.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Catalase (EC:1.11.1.6)
    Alternative name(s):
    Paraquat-inducible catalase isozyme B
    Gene namesi
    Name:katB
    Ordered Locus Names:PA4613
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA4613.

    Subcellular locationi

    Periplasm Curated

    GO - Cellular componenti

    1. periplasmic space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Periplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 513483CatalasePRO_0000004693Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA4613.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59635.
    SMRiQ59635. Positions 32-513.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the catalase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0753.
    HOGENOMiHOG000087852.
    KOiK03781.
    OMAiDDESKHI.
    OrthoDBiEOG6P5Z9F.
    PhylomeDBiQ59635.

    Family and domain databases

    Gene3Di2.40.180.10. 1 hit.
    InterProiIPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view]
    PANTHERiPTHR11465. PTHR11465. 1 hit.
    PfamiPF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSiPR00067. CATALASE.
    SMARTiSM01060. Catalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56634. SSF56634. 1 hit.
    PROSITEiPS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q59635-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPSLNAFRP GRLLVAASLT ASLLSLSVQA ATLTRDNGAP VGDNQNSQTA    50
    GPNGSVLLQD VQLLQKLQRF DRERIPERVV HARGTGAHGE FVASADISDL 100
    SMAKVFRKGE KTPVFVRFSA VVHGNHSPET LRDPRGFATK FYTADGNWDL 150
    VGNNFPTFFI RDAIKFPDMV HAFKPDPRSN LDDDSRRFDF FSHVPEATRT 200
    LTLLYSNEGT PASYREMDGN SVHAYKLVNA RGEVHYVKFH WKSLQGQKNL 250
    DPKQVAEVQG RDYSHMTNDL VSAIRKGDFP KWDLYIQVLK PEDLAKFDFD 300
    PLDATKIWPG IPERKIGQMV LNRNVDNFFQ ETEQVAMAPS NLVPGIEPSE 350
    DRLLQGRLFA YADTQMYRVG ANGLGLPVNR PRSEVNTVNQ DGALNAGHST 400
    SGVNYQPSRL DPREEQASAR YVRTPLSGTT QQAKIQREQN FKQTGELFRS 450
    YGKKDQADLI ASLGGALAIT DDESKYIMLS YFYKADSDYG TGLAKVAGAD 500
    LQRVRQLAAK LQD 513
    Length:513
    Mass (Da):57,131
    Last modified:November 1, 1996 - v1
    Checksum:iC9A09B88629A11CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34896 Genomic DNA. Translation: AAA79046.1.
    U89384 Genomic DNA. Translation: AAB49463.1.
    AE004091 Genomic DNA. Translation: AAG08001.1.
    PIRiE83069.
    RefSeqiNP_253303.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG08001; AAG08001; PA4613.
    GeneIDi881120.
    KEGGipae:PA4613.
    PATRICi19843973. VBIPseAer58763_4828.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34896 Genomic DNA. Translation: AAA79046.1 .
    U89384 Genomic DNA. Translation: AAB49463.1 .
    AE004091 Genomic DNA. Translation: AAG08001.1 .
    PIRi E83069.
    RefSeqi NP_253303.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali Q59635.
    SMRi Q59635. Positions 32-513.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA4613.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG08001 ; AAG08001 ; PA4613 .
    GeneIDi 881120.
    KEGGi pae:PA4613.
    PATRICi 19843973. VBIPseAer58763_4828.

    Organism-specific databases

    PseudoCAPi PA4613.

    Phylogenomic databases

    eggNOGi COG0753.
    HOGENOMi HOG000087852.
    KOi K03781.
    OMAi DDESKHI.
    OrthoDBi EOG6P5Z9F.
    PhylomeDBi Q59635.

    Enzyme and pathway databases

    SABIO-RK Q59635.

    Family and domain databases

    Gene3Di 2.40.180.10. 1 hit.
    InterProi IPR018028. Catalase.
    IPR020835. Catalase-like_dom.
    IPR024708. Catalase_AS.
    IPR024711. Catalase_clade1/3.
    IPR011614. Catalase_core.
    IPR002226. Catalase_haem_BS.
    IPR010582. Catalase_immune_responsive.
    [Graphical view ]
    PANTHERi PTHR11465. PTHR11465. 1 hit.
    Pfami PF00199. Catalase. 1 hit.
    PF06628. Catalase-rel. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038928. Catalase_clade1-3. 1 hit.
    PRINTSi PR00067. CATALASE.
    SMARTi SM01060. Catalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56634. SSF56634. 1 hit.
    PROSITEi PS00437. CATALASE_1. 1 hit.
    PS00438. CATALASE_2. 1 hit.
    PS51402. CATALASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: purification of KatB, cellular localization, and demonstration that it is essential for optimal resistance to hydrogen peroxide."
      Brown S.M., Howell M.L., Vasil M.L., Anderson A.J., Hassett D.J.
      J. Bacteriol. 177:6536-6544(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FRD2.
    2. "Pseudomonas aeruginosa oxidative stress operon."
      Howell M.L., Heur M., Klotz M.G., Hassett D.J.
      Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FRD1.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiCATB_PSEAE
    AccessioniPrimary (citable) accession number: Q59635
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3