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Q59635 (CATB_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Catalase

EC=1.11.1.6
Alternative name(s):
Paraquat-inducible catalase isozyme B
Gene names
Name:katB
Ordered Locus Names:PA4613
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length513 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activity

2 H2O2 = O2 + 2 H2O.

Cofactor

Heme group.

Subcellular location

Periplasm Probable.

Sequence similarities

Belongs to the catalase family.

Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentPeriplasm
   DomainSignal
   LigandHeme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperiplasmic space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncatalase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 513483Catalase
PRO_0000004693

Sites

Active site811 By similarity
Active site1531 By similarity
Metal binding3611Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q59635 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C9A09B88629A11CB

FASTA51357,131
        10         20         30         40         50         60 
MNPSLNAFRP GRLLVAASLT ASLLSLSVQA ATLTRDNGAP VGDNQNSQTA GPNGSVLLQD 

        70         80         90        100        110        120 
VQLLQKLQRF DRERIPERVV HARGTGAHGE FVASADISDL SMAKVFRKGE KTPVFVRFSA 

       130        140        150        160        170        180 
VVHGNHSPET LRDPRGFATK FYTADGNWDL VGNNFPTFFI RDAIKFPDMV HAFKPDPRSN 

       190        200        210        220        230        240 
LDDDSRRFDF FSHVPEATRT LTLLYSNEGT PASYREMDGN SVHAYKLVNA RGEVHYVKFH 

       250        260        270        280        290        300 
WKSLQGQKNL DPKQVAEVQG RDYSHMTNDL VSAIRKGDFP KWDLYIQVLK PEDLAKFDFD 

       310        320        330        340        350        360 
PLDATKIWPG IPERKIGQMV LNRNVDNFFQ ETEQVAMAPS NLVPGIEPSE DRLLQGRLFA 

       370        380        390        400        410        420 
YADTQMYRVG ANGLGLPVNR PRSEVNTVNQ DGALNAGHST SGVNYQPSRL DPREEQASAR 

       430        440        450        460        470        480 
YVRTPLSGTT QQAKIQREQN FKQTGELFRS YGKKDQADLI ASLGGALAIT DDESKYIMLS 

       490        500        510 
YFYKADSDYG TGLAKVAGAD LQRVRQLAAK LQD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the katB gene of Pseudomonas aeruginosa encoding a hydrogen peroxide-inducible catalase: purification of KatB, cellular localization, and demonstration that it is essential for optimal resistance to hydrogen peroxide."
Brown S.M., Howell M.L., Vasil M.L., Anderson A.J., Hassett D.J.
J. Bacteriol. 177:6536-6544(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FRD2.
[2]"Pseudomonas aeruginosa oxidative stress operon."
Howell M.L., Heur M., Klotz M.G., Hassett D.J.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FRD1.
[3]"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen."
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. expand/collapse author list , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.
Nature 406:959-964(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34896 Genomic DNA. Translation: AAA79046.1.
U89384 Genomic DNA. Translation: AAB49463.1.
AE004091 Genomic DNA. Translation: AAG08001.1.
PIRE83069.
RefSeqNP_253303.1. NC_002516.2.

3D structure databases

ProteinModelPortalQ59635.
SMRQ59635. Positions 32-513.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA4613.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID881120.
KEGGpae:PA4613.
PATRIC19843973. VBIPseAer58763_4828.

Organism-specific databases

PseudoCAPPA4613.

Phylogenomic databases

eggNOGCOG0753.
HOGENOMHOG000087852.
KOK03781.
OMAEATTMIM.
OrthoDBEOG6P5Z9F.
ProtClustDBCLSK868779.

Enzyme and pathway databases

SABIO-RKQ59635.

Family and domain databases

Gene3D2.40.180.10. 1 hit.
InterProIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERPTHR11465. PTHR11465. 1 hit.
PfamPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSPR00067. CATALASE.
SMARTSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMSSF56634. SSF56634. 1 hit.
PROSITEPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCATB_PSEAE
AccessionPrimary (citable) accession number: Q59635
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families