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Protein

Modification methylase NgoFVII

Gene

ngoFVIIM

Organism
Neisseria gonorrhoeae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GCSGC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the NgoFVII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3611. M.NgoFVII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase NgoFVII (EC:2.1.1.37)
Short name:
M.NgoFVII
Alternative name(s):
Cytosine-specific methyltransferase NgoFVII
Short name:
M.NgoVII
Gene namesi
Name:ngoFVIIM
Synonyms:dcmG
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878981 – 374Modification methylase NgoFVIIAdd BLAST374

Structurei

3D structure databases

ProteinModelPortaliQ59606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 344SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST329

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105NI8. Bacteria.
COG0270. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF00145. DNA_methylase. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiView protein in PROSITE
PS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59606-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKQISNLN SSSNKPKILS LFSGCGGLDL GFHQAGCETV WANDFSHWAC
60 70 80 90 100
ESFRKNIGDV IVEGDIEQIN PNDPTIPDCD IILGGFPCQD FSMIWKQPGL
110 120 130 140 150
EGERGNLYKS FLRFVNAKKP KVFVAENVKG LLTANKKKAI QQIITDFENC
160 170 180 190 200
GYYVQANVYN FAEFGVPQFR ERVLIVGVRL DTGFDFRHPE PTHNETGENG
210 220 230 240 250
LKPYVTAGQA ISNIPQNASN NELLKISDKT RRMLELIPEG GNFTDIPKDH
260 270 280 290 300
PLYVKGMISH VYRRMHRNEP SKTIIAAGGG GTWGYHFPEP RAFTNRERAR
310 320 330 340 350
LQSFPDDFEF VGSTTEVRRQ IGNAVPPQGV VELAKSILPI FSDNYEKVDL
360 370
HEKLVEEKEI LFHDRLSKIR GGKQ
Length:374
Mass (Da):42,073
Last modified:November 1, 1996 - v1
Checksum:i6210BA089D906894
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43736 Genomic DNA. Translation: AAA86270.1.
PIRiT10165.

Similar proteinsi

Entry informationi

Entry nameiMTF7_NEIGO
AccessioniPrimary (citable) accession number: Q59606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families