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Q59606

- MTF7_NEIGO

UniProt

Q59606 - MTF7_NEIGO

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Protein

Modification methylase NgoFVII

Gene

ngoFVIIM

Organism
Neisseria gonorrhoeae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GCSGC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the NgoFVII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881PROSITE-ProRule annotation

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3611. M.NgoFVII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase NgoFVII (EC:2.1.1.37)
Short name:
M.NgoFVII
Alternative name(s):
Cytosine-specific methyltransferase NgoFVII
Short name:
M.NgoVII
Gene namesi
Name:ngoFVIIM
Synonyms:dcmG
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Modification methylase NgoFVIIPRO_0000087898Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ59606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 344329SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59606-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSKQISNLN SSSNKPKILS LFSGCGGLDL GFHQAGCETV WANDFSHWAC
60 70 80 90 100
ESFRKNIGDV IVEGDIEQIN PNDPTIPDCD IILGGFPCQD FSMIWKQPGL
110 120 130 140 150
EGERGNLYKS FLRFVNAKKP KVFVAENVKG LLTANKKKAI QQIITDFENC
160 170 180 190 200
GYYVQANVYN FAEFGVPQFR ERVLIVGVRL DTGFDFRHPE PTHNETGENG
210 220 230 240 250
LKPYVTAGQA ISNIPQNASN NELLKISDKT RRMLELIPEG GNFTDIPKDH
260 270 280 290 300
PLYVKGMISH VYRRMHRNEP SKTIIAAGGG GTWGYHFPEP RAFTNRERAR
310 320 330 340 350
LQSFPDDFEF VGSTTEVRRQ IGNAVPPQGV VELAKSILPI FSDNYEKVDL
360 370
HEKLVEEKEI LFHDRLSKIR GGKQ
Length:374
Mass (Da):42,073
Last modified:November 1, 1996 - v1
Checksum:i6210BA089D906894
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43736 Genomic DNA. Translation: AAA86270.1.
PIRiT10165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43736 Genomic DNA. Translation: AAA86270.1 .
PIRi T10165.

3D structure databases

ProteinModelPortali Q59606.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3611. M.NgoFVII.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Restriction and modification systems of Neisseria gonorrhoeae."
    Stein D.C., Gunn J.S., Radlinska M., Piekarowicz A.
    Gene 157:19-22(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1291C.

Entry informationi

Entry nameiMTF7_NEIGO
AccessioniPrimary (citable) accession number: Q59606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3