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Protein

Modification methylase NgoBI

Gene

ngoBIM

Organism
Neisseria gonorrhoeae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence RGCGCY, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the NgoBI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3607 M.NgoBI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase NgoBI (EC:2.1.1.37)
Short name:
M.NgoBI
Alternative name(s):
Cytosine-specific methyltransferase NgoBI
Short name:
M.NgoI
Gene namesi
Name:ngoBIM
OrganismiNeisseria gonorrhoeae
Taxonomic identifieri485 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878961 – 317Modification methylase NgoBIAdd BLAST317

Structurei

3D structure databases

ProteinModelPortaliQ59603
SMRiQ59603
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 302SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST301

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

Q59603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKTIDLFSG IGGIRLGFEK YGCTNVFSSE WDKYARQVYE ANFGEKPFGD
60 70 80 90 100
INGIDPSDIP DHDILLAGFP CQPFSIAGKG LGFEDTRGTL FFNIAEILKT
110 120 130 140 150
KQPKAFLLEN VKRLTTHDSG RTFRIVLETL KQLGYTVYFK VLNTLDFGLP
160 170 180 190 200
QKRERIYIVG FSDNIPFYFP EPINQYRPLG ELLENDRDVE PSYFLSDTLK
210 220 230 240 250
QKRLAALKKA PPTPSIWHEN IGGNVSALPY SCALRAGGSY NYLVVNGVRR
260 270 280 290 300
LTGREMLRLQ GFPDDFEINI PYSQVRKVAG NSVSVPVIEA TRKICSLLFP
310
ARSNKKGNWI YWRQDDA
Length:317
Mass (Da):35,949
Last modified:May 1, 2000 - v2
Checksum:iF0549A5259D1A414
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42459 Genomic DNA Translation: AAB03206.2

Similar proteinsi

Entry informationi

Entry nameiMTB1_NEIGO
AccessioniPrimary (citable) accession number: Q59603
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health