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Protein

Fimbrial protein

Gene

pilA

Organism
Myxococcus xanthus (strain DK 1622)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Makes up the pili which are long filamentous (less than 10 nm thick and up to 10 um long) polarly located appendages. They are required for social (S) motility.1 Publication

Miscellaneous

Pilin assembly limits pilus production and S motility. This limitation could be linked to the high frequency of reversal of gliding direction observed in M.xanthus. Reversal implies loss of pili at the leading pole of the cell and commissioning of new pili assembly at the other pole.

Enzyme and pathway databases

BioCyciMXAN246197:G1G53-5687-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Fimbrial protein
Alternative name(s):
Pilin
Gene namesi
Name:pilA
Ordered Locus Names:MXAN_5783
OrganismiMyxococcus xanthus (strain DK 1622)
Taxonomic identifieri246197 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeMyxococcaceaeMyxococcus
Proteomesi
  • UP000002402 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • pilus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Fimbrium

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49K → E: Pilus-minus S phenotype. 1 Publication1
Mutagenesisi193G → D: Pilus-minus S phenotype. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00002467801 – 12By similarityAdd BLAST12
ChainiPRO_000024678113 – 220Fimbrial proteinAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13N-methylphenylalaninePROSITE-ProRule annotation1

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiQ59589

Expressioni

Inductioni

Expression of pilA seems to be negatively regulated by the accumulation of pilin at a cell end. This may be sensed by the PilR-PilS two-component system.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi246197.MXAN_5783

Structurei

3D structure databases

ProteinModelPortaliQ59589
SMRiQ59589
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N-Me-Phe pilin family.Curated

Phylogenomic databases

eggNOGiENOG4106855 Bacteria
ENOG410XUCS LUCA
HOGENOMiHOG000115547
KOiK02650
OMAiWVIAGFE
OrthoDBiPOG091H0QV3

Family and domain databases

InterProiView protein in InterPro
IPR012902 N_methyl_site
IPR028188 Pilin_PilA
PfamiView protein in Pfam
PF07963 N_methyl, 1 hit
PF14245 Pilin_PilA, 1 hit
TIGRFAMsiTIGR02532 IV_pilin_GFxxxE, 1 hit
PROSITEiView protein in PROSITE
PS00409 PROKAR_NTER_METHYL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSRFNPRN RGFTLIELMI VVAIIGILAA IAIPNFIKFQ ARSKQSEAKT
60 70 80 90 100
NLKALYTAQK SFFSEKDRYS DFANEIGFAP ERGNRYGYRV SAAAGDCEVR
110 120 130 140 150
NAADLPVPAA GVPCISNDSF RFGANSAIDD PTPVVARFVP QGAAGWNTTL
160 170 180 190 200
GVQPTIADCP NCNFFAGARG NADNEATFDD WVIAGFEGSG QVGPCSEAGN
210 220
VASGTPYNTR NDVACDGAAQ
Length:220
Mass (Da):23,388
Last modified:November 1, 1996 - v1
Checksum:i20B7B699C74DE3DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39904 Genomic DNA Translation: AAB40882.1
CP000113 Genomic DNA Translation: ABF90139.1
PIRiS70530
RefSeqiWP_011555734.1, NC_008095.1

Genome annotation databases

EnsemblBacteriaiABF90139; ABF90139; MXAN_5783
KEGGimxa:MXAN_5783

Similar proteinsi

Entry informationi

Entry nameiPILA_MYXXD
AccessioniPrimary (citable) accession number: Q59589
Secondary accession number(s): Q1D0A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health