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Q59587

- RISC_METTM

UniProt

Q59587 - RISC_METTM

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Protein

Riboflavin synthase

Gene

ribC

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

The relatively low activity of this enzyme suggested that 6,7-dimethyl-8-ribityllumazine might not be its natural substrate.

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Cofactori

Magnesium.

Enzyme regulationi

Inhibited by EDTA.

Pathwayi

GO - Molecular functioni

  1. riboflavin synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. riboflavin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Riboflavin biosynthesis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-587-MONOMER.
BRENDAi2.5.1.9. 3256.
UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Gene namesi
Name:ribC
Ordered Locus Names:MTBMA_c05840
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. riboflavin synthase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153Riboflavin synthasePRO_0000134862Add
BLAST

Interactioni

Subunit structurei

Homooligomer.

Structurei

3D structure databases

ProteinModelPortaliQ59587.
SMRiQ59587. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRL synthase family.Curated

Phylogenomic databases

HOGENOMiHOG000227234.
KOiK00793.
OMAiGIVDTTF.

Family and domain databases

Gene3Di3.40.50.960. 1 hit.
InterProiIPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view]
PfamiPF00885. DMRL_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMiSSF52121. SSF52121. 1 hit.
TIGRFAMsiTIGR01506. ribC_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59587-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKVGICDTT FARYDMGGAA IDEIKKHATG IKIIRRTVPG IKDLPVACKK
60 70 80 90 100
LIEEEGCEMV MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH
110 120 130 140 150
EDEEDDPEDL KVLADNRARE HAQNLIMMLF RPERLTRDAG MGMREGKPDV

GPL
Length:153
Mass (Da):16,969
Last modified:November 1, 1996 - v1
Checksum:iCAAE34FDA348F534
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94292 Genomic DNA. Translation: CAA63959.1.
CP001710 Genomic DNA. Translation: ADL58179.1.
RefSeqiYP_003849492.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL58179; ADL58179; MTBMA_c05840.
GeneIDi9704292.
KEGGimmg:MTBMA_c05840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X94292 Genomic DNA. Translation: CAA63959.1 .
CP001710 Genomic DNA. Translation: ADL58179.1 .
RefSeqi YP_003849492.1. NC_014408.1.

3D structure databases

ProteinModelPortali Q59587.
SMRi Q59587. Positions 3-152.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL58179 ; ADL58179 ; MTBMA_c05840 .
GeneIDi 9704292.
KEGGi mmg:MTBMA_c05840.

Phylogenomic databases

HOGENOMi HOG000227234.
KOi K00793.
OMAi GIVDTTF.

Enzyme and pathway databases

UniPathwayi UPA00275 ; UER00405 .
BioCyci MMAR79929:GH5J-587-MONOMER.
BRENDAi 2.5.1.9. 3256.

Family and domain databases

Gene3Di 3.40.50.960. 1 hit.
InterProi IPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view ]
Pfami PF00885. DMRL_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMi SSF52121. SSF52121. 1 hit.
TIGRFAMsi TIGR01506. ribC_arch. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Biosynthesis of riboflavin: an unusual riboflavin synthase of Methanobacterium thermoautotrophicum."
    Eberhardt S., Korn S., Lottspeich F., Bacher A.
    J. Bacteriol. 179:2938-2943(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-42 AND 129-151.
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
  2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Entry informationi

Entry nameiRISC_METTM
AccessioniPrimary (citable) accession number: Q59587
Secondary accession number(s): D9PVD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3