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Q59587 (RISC_METTM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The relatively low activity of this enzyme suggested that 6,7-dimethyl-8-ribityllumazine might not be its natural substrate.

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Cofactor

Magnesium.

Enzyme regulation

Inhibited by EDTA.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.

Subunit structure

Homooligomer.

Sequence similarities

Belongs to the DMRL synthase family.

Ontologies

Keywords
   Biological processRiboflavin biosynthesis
   LigandMagnesium
   Molecular functionTransferase
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological_processriboflavin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentriboflavin synthase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionriboflavin synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153Riboflavin synthase
PRO_0000134862

Sequences

Sequence LengthMass (Da)Tools
Q59587 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CAAE34FDA348F534

FASTA15316,969
        10         20         30         40         50         60 
MIKVGICDTT FARYDMGGAA IDEIKKHATG IKIIRRTVPG IKDLPVACKK LIEEEGCEMV 

        70         80         90        100        110        120 
MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH EDEEDDPEDL KVLADNRARE 

       130        140        150 
HAQNLIMMLF RPERLTRDAG MGMREGKPDV GPL 

« Hide

References

« Hide 'large scale' references
[1]"Biosynthesis of riboflavin: an unusual riboflavin synthase of Methanobacterium thermoautotrophicum."
Eberhardt S., Korn S., Lottspeich F., Bacher A.
J. Bacteriol. 179:2938-2943(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-42 AND 129-151.
Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
[2]"Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X94292 Genomic DNA. Translation: CAA63959.1.
CP001710 Genomic DNA. Translation: ADL58179.1.
RefSeqYP_003849492.1. NC_014408.1.

3D structure databases

ProteinModelPortalQ59587.
SMRQ59587. Positions 3-152.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADL58179; ADL58179; MTBMA_c05840.
GeneID9704292.
KEGGmmg:MTBMA_c05840.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000227234.
KOK00793.
OMAGIVDTTF.

Enzyme and pathway databases

BioCycMMAR79929:GH5J-587-MONOMER.
BRENDA2.5.1.9. 3256.
UniPathwayUPA00275; UER00405.

Family and domain databases

Gene3D3.40.50.960. 1 hit.
InterProIPR002180. DMRL_synthase.
IPR006399. Ribfl_synth_arc.
[Graphical view]
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF015750. Ribfl_synth_arc. 1 hit.
SUPFAMSSF52121. SSF52121. 1 hit.
TIGRFAMsTIGR01506. ribC_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRISC_METTM
AccessionPrimary (citable) accession number: Q59587
Secondary accession number(s): D9PVD1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways