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Q59587

- RISC_METTM

UniProt

Q59587 - RISC_METTM

Protein

Riboflavin synthase

Gene

ribC

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    The relatively low activity of this enzyme suggested that 6,7-dimethyl-8-ribityllumazine might not be its natural substrate.

    Catalytic activityi

    2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

    Cofactori

    Magnesium.

    Enzyme regulationi

    Inhibited by EDTA.

    Pathwayi

    GO - Molecular functioni

    1. riboflavin synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. riboflavin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Riboflavin biosynthesis

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciMMAR79929:GH5J-587-MONOMER.
    BRENDAi2.5.1.9. 3256.
    UniPathwayiUPA00275; UER00405.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Riboflavin synthase (EC:2.5.1.9)
    Gene namesi
    Name:ribC
    Ordered Locus Names:MTBMA_c05840
    OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
    Taxonomic identifieri79929 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000000345: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. riboflavin synthase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153Riboflavin synthasePRO_0000134862Add
    BLAST

    Interactioni

    Subunit structurei

    Homooligomer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59587.
    SMRiQ59587. Positions 3-152.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DMRL synthase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000227234.
    KOiK00793.
    OMAiGIVDTTF.

    Family and domain databases

    Gene3Di3.40.50.960. 1 hit.
    InterProiIPR002180. DMRL_synthase.
    IPR006399. Ribfl_synth_arc.
    [Graphical view]
    PfamiPF00885. DMRL_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015750. Ribfl_synth_arc. 1 hit.
    SUPFAMiSSF52121. SSF52121. 1 hit.
    TIGRFAMsiTIGR01506. ribC_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59587-1 [UniParc]FASTAAdd to Basket

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    MIKVGICDTT FARYDMGGAA IDEIKKHATG IKIIRRTVPG IKDLPVACKK    50
    LIEEEGCEMV MALGMPGPEE KDKVCAHEAS TGLIQAQLMT NTHILEVFVH 100
    EDEEDDPEDL KVLADNRARE HAQNLIMMLF RPERLTRDAG MGMREGKPDV 150
    GPL 153
    Length:153
    Mass (Da):16,969
    Last modified:November 1, 1996 - v1
    Checksum:iCAAE34FDA348F534
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94292 Genomic DNA. Translation: CAA63959.1.
    CP001710 Genomic DNA. Translation: ADL58179.1.
    RefSeqiYP_003849492.1. NC_014408.1.

    Genome annotation databases

    EnsemblBacteriaiADL58179; ADL58179; MTBMA_c05840.
    GeneIDi9704292.
    KEGGimmg:MTBMA_c05840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94292 Genomic DNA. Translation: CAA63959.1 .
    CP001710 Genomic DNA. Translation: ADL58179.1 .
    RefSeqi YP_003849492.1. NC_014408.1.

    3D structure databases

    ProteinModelPortali Q59587.
    SMRi Q59587. Positions 3-152.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL58179 ; ADL58179 ; MTBMA_c05840 .
    GeneIDi 9704292.
    KEGGi mmg:MTBMA_c05840.

    Phylogenomic databases

    HOGENOMi HOG000227234.
    KOi K00793.
    OMAi GIVDTTF.

    Enzyme and pathway databases

    UniPathwayi UPA00275 ; UER00405 .
    BioCyci MMAR79929:GH5J-587-MONOMER.
    BRENDAi 2.5.1.9. 3256.

    Family and domain databases

    Gene3Di 3.40.50.960. 1 hit.
    InterProi IPR002180. DMRL_synthase.
    IPR006399. Ribfl_synth_arc.
    [Graphical view ]
    Pfami PF00885. DMRL_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015750. Ribfl_synth_arc. 1 hit.
    SUPFAMi SSF52121. SSF52121. 1 hit.
    TIGRFAMsi TIGR01506. ribC_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Biosynthesis of riboflavin: an unusual riboflavin synthase of Methanobacterium thermoautotrophicum."
      Eberhardt S., Korn S., Lottspeich F., Bacher A.
      J. Bacteriol. 179:2938-2943(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-42 AND 129-151.
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
    2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
      Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
      J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.

    Entry informationi

    Entry nameiRISC_METTM
    AccessioniPrimary (citable) accession number: Q59587
    Secondary accession number(s): D9PVD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3