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Q59548

- SECY_MYCPN

UniProt

Q59548 - SECY_MYCPN

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Protein

Protein translocase subunit SecY

Gene
secY, MPN_184, MP647
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity.UniRule annotation

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein targeting Source: UniProtKB-HAMAP
  3. protein transport by the Sec complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciMPNE272634:GJ6Z-191-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecY
Gene namesi
Name:secY
Ordered Locus Names:MPN_184
ORF Names:MP647
OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
Taxonomic identifieri272634 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000000808: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei28 – 4821Helical; Reviewed predictionAdd
BLAST
Transmembranei67 – 8923Helical; Reviewed predictionAdd
BLAST
Transmembranei130 – 15021Helical; Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Transmembranei196 – 21621Helical; Reviewed predictionAdd
BLAST
Transmembranei234 – 25421Helical; Reviewed predictionAdd
BLAST
Transmembranei286 – 30621Helical; Reviewed predictionAdd
BLAST
Transmembranei329 – 34921Helical; Reviewed predictionAdd
BLAST
Transmembranei387 – 40721Helical; Reviewed predictionAdd
BLAST
Transmembranei413 – 43321Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Protein translocase subunit SecYUniRule annotationPRO_0000131736Add
BLAST

Proteomic databases

PaxDbiQ59548.

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity.

Protein-protein interaction databases

STRINGi272634.MPN184.

Structurei

3D structure databases

ProteinModelPortaliQ59548.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0201.
KOiK03076.
OMAiAWNVQFY.
OrthoDBiEOG651SWP.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59548-1 [UniParc]FASTAAdd to Basket

« Hide

MQAKPTTAVK QKQNFGQRLF TLLRNRDFMI SFLITVVLLV LFRVLAIIPL    50
PGIQVNQTGL DQNSNDFFSL FNLLGGGGLN QLSLFAVGIS PYISAQIVMQ 100
LLSTDLIPPL SKLVNSGEVG RRKIEMITRI ITLPFALVQS FAVIQIATNS 150
GGGSSPITLK NNGSDFVAFY IIAMTAGTYL SVFLGDTISK KGIGNGITLL 200
ILSGILAQLP EGFIAAYSVL SGVVVTINAT LTTAISFFIY FMAFVTLLFA 250
TTFITQETRK IPIQQSGQGL VTESSALPYL PIKVNSAGVI PVIFASSIMS 300
IPVTIAQFQP QTESRWFVED YLSLSKPTGI VLYGILVILF SFFYSYIQIN 350
PERLAKNFEK SGRFIPGIRP GKDTEKHIAR VLVRINFIGA PFLTVIAIIP 400
YIVSALIHLP NSLSLGGTGI IIIVTAVVEF MSALRSAATA TNYQQLRRNL 450
AIEVQKTAQQ DKEEQLRAET PGIGNLW 477
Length:477
Mass (Da):51,967
Last modified:November 1, 1997 - v1
Checksum:i0301F8F0D8D4BD88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34795 Genomic DNA. Translation: AAC43697.1.
U00089 Genomic DNA. Translation: AAB96295.1.
PIRiS62824.
RefSeqiNP_109872.1. NC_000912.1.
WP_010874541.1. NC_000912.1.

Genome annotation databases

EnsemblBacteriaiAAB96295; AAB96295; MPN_184.
GeneIDi876763.
KEGGimpn:MPN184.
PATRICi20021691. VBIMycPne110_0202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34795 Genomic DNA. Translation: AAC43697.1 .
U00089 Genomic DNA. Translation: AAB96295.1 .
PIRi S62824.
RefSeqi NP_109872.1. NC_000912.1.
WP_010874541.1. NC_000912.1.

3D structure databases

ProteinModelPortali Q59548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272634.MPN184.

Proteomic databases

PaxDbi Q59548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAB96295 ; AAB96295 ; MPN_184 .
GeneIDi 876763.
KEGGi mpn:MPN184.
PATRICi 20021691. VBIMycPne110_0202.

Phylogenomic databases

eggNOGi COG0201.
KOi K03076.
OMAi AWNVQFY.
OrthoDBi EOG651SWP.

Enzyme and pathway databases

BioCyci MPNE272634:GJ6Z-191-MONOMER.

Family and domain databases

Gene3Di 1.10.3370.10. 1 hit.
HAMAPi MF_01465. SecY.
InterProi IPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view ]
PANTHERi PTHR10906. PTHR10906. 1 hit.
Pfami PF00344. SecY. 1 hit.
[Graphical view ]
PIRSFi PIRSF004557. SecY. 1 hit.
SUPFAMi SSF103491. SSF103491. 1 hit.
TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
PROSITEi PS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes."
    Hilbert H., Himmelreich R., Plagens H., Herrmann R.
    Nucleic Acids Res. 24:628-639(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 29342 / M129.
  2. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
    Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
    Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29342 / M129.

Entry informationi

Entry nameiSECY_MYCPN
AccessioniPrimary (citable) accession number: Q59548
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycoplasma pneumoniae
    Mycoplasma pneumoniae (strain M129): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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