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Q59548

- SECY_MYCPN

UniProt

Q59548 - SECY_MYCPN

Protein

Protein translocase subunit SecY

Gene

secY

Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein targeting Source: UniProtKB-HAMAP
    3. protein transport by the Sec complex Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    BioCyciMPNE272634:GJ6Z-191-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecYUniRule annotation
    Gene namesi
    Name:secYUniRule annotation
    Ordered Locus Names:MPN_184
    ORF Names:MP647
    OrganismiMycoplasma pneumoniae (strain ATCC 29342 / M129)
    Taxonomic identifieri272634 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
    ProteomesiUP000000808: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: GOC
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 477477Protein translocase subunit SecYPRO_0000131736Add
    BLAST

    Proteomic databases

    PaxDbiQ59548.

    Interactioni

    Subunit structurei

    Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

    Protein-protein interaction databases

    STRINGi272634.MPN184.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59548.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821HelicalUniRule annotationAdd
    BLAST
    Transmembranei67 – 8923HelicalUniRule annotationAdd
    BLAST
    Transmembranei130 – 15021HelicalUniRule annotationAdd
    BLAST
    Transmembranei165 – 18521HelicalUniRule annotationAdd
    BLAST
    Transmembranei196 – 21621HelicalUniRule annotationAdd
    BLAST
    Transmembranei234 – 25421HelicalUniRule annotationAdd
    BLAST
    Transmembranei286 – 30621HelicalUniRule annotationAdd
    BLAST
    Transmembranei329 – 34921HelicalUniRule annotationAdd
    BLAST
    Transmembranei387 – 40721HelicalUniRule annotationAdd
    BLAST
    Transmembranei413 – 43321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecY/SEC61-alpha family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0201.
    KOiK03076.
    OMAiAWNVQFY.
    OrthoDBiEOG651SWP.

    Family and domain databases

    Gene3Di1.10.3370.10. 1 hit.
    HAMAPiMF_01465. SecY.
    InterProiIPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    [Graphical view]
    PANTHERiPTHR10906. PTHR10906. 1 hit.
    PfamiPF00344. SecY. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004557. SecY. 1 hit.
    SUPFAMiSSF103491. SSF103491. 1 hit.
    TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
    PROSITEiPS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59548-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQAKPTTAVK QKQNFGQRLF TLLRNRDFMI SFLITVVLLV LFRVLAIIPL    50
    PGIQVNQTGL DQNSNDFFSL FNLLGGGGLN QLSLFAVGIS PYISAQIVMQ 100
    LLSTDLIPPL SKLVNSGEVG RRKIEMITRI ITLPFALVQS FAVIQIATNS 150
    GGGSSPITLK NNGSDFVAFY IIAMTAGTYL SVFLGDTISK KGIGNGITLL 200
    ILSGILAQLP EGFIAAYSVL SGVVVTINAT LTTAISFFIY FMAFVTLLFA 250
    TTFITQETRK IPIQQSGQGL VTESSALPYL PIKVNSAGVI PVIFASSIMS 300
    IPVTIAQFQP QTESRWFVED YLSLSKPTGI VLYGILVILF SFFYSYIQIN 350
    PERLAKNFEK SGRFIPGIRP GKDTEKHIAR VLVRINFIGA PFLTVIAIIP 400
    YIVSALIHLP NSLSLGGTGI IIIVTAVVEF MSALRSAATA TNYQQLRRNL 450
    AIEVQKTAQQ DKEEQLRAET PGIGNLW 477
    Length:477
    Mass (Da):51,967
    Last modified:November 1, 1997 - v1
    Checksum:i0301F8F0D8D4BD88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34795 Genomic DNA. Translation: AAC43697.1.
    U00089 Genomic DNA. Translation: AAB96295.1.
    PIRiS62824.
    RefSeqiNP_109872.1. NC_000912.1.
    WP_010874541.1. NC_000912.1.

    Genome annotation databases

    EnsemblBacteriaiAAB96295; AAB96295; MPN_184.
    GeneIDi876763.
    KEGGimpn:MPN184.
    PATRICi20021691. VBIMycPne110_0202.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34795 Genomic DNA. Translation: AAC43697.1 .
    U00089 Genomic DNA. Translation: AAB96295.1 .
    PIRi S62824.
    RefSeqi NP_109872.1. NC_000912.1.
    WP_010874541.1. NC_000912.1.

    3D structure databases

    ProteinModelPortali Q59548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272634.MPN184.

    Proteomic databases

    PaxDbi Q59548.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAB96295 ; AAB96295 ; MPN_184 .
    GeneIDi 876763.
    KEGGi mpn:MPN184.
    PATRICi 20021691. VBIMycPne110_0202.

    Phylogenomic databases

    eggNOGi COG0201.
    KOi K03076.
    OMAi AWNVQFY.
    OrthoDBi EOG651SWP.

    Enzyme and pathway databases

    BioCyci MPNE272634:GJ6Z-191-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3370.10. 1 hit.
    HAMAPi MF_01465. SecY.
    InterProi IPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    [Graphical view ]
    PANTHERi PTHR10906. PTHR10906. 1 hit.
    Pfami PF00344. SecY. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004557. SecY. 1 hit.
    SUPFAMi SSF103491. SSF103491. 1 hit.
    TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
    PROSITEi PS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of 56 kb from the genome of the bacterium Mycoplasma pneumoniae comprising the dnaA region, the atp operon and a cluster of ribosomal protein genes."
      Hilbert H., Himmelreich R., Plagens H., Herrmann R.
      Nucleic Acids Res. 24:628-639(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 29342 / M129.
    2. "Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae."
      Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.
      Nucleic Acids Res. 24:4420-4449(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29342 / M129.

    Entry informationi

    Entry nameiSECY_MYCPN
    AccessioniPrimary (citable) accession number: Q59548
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Mycoplasma pneumoniae
      Mycoplasma pneumoniae (strain M129): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3