Reviewed, UniProtKB/Swiss-Prot Q59545 (XYLD_MORMO)

Names and origin

Protein names	Recommended name:     D-xylulose reductase     EC=1.1.1.9 Alternative name(s):     Xylitol dehydrogenase       Short name=XDH
Organism	Morganella morganii (Proteus morganii)
Taxonomic identifier	582 [NCBI]
Taxonomic lineage	Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Morganella

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Xylitol + NAD+ = D-xylulose + NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homotetramer Potential.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-xylulose reductase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	D-xylulose reductase		PRO_0000160885
Sites
	Metal binding	40	1	Zinc; catalytic By similarity
	Metal binding	65	1	Zinc; catalytic By similarity
	Metal binding	151	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q59545-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 4C6119553DC51873	FASTA	338	35,952
	10 20 30 40 50 60 MIMKALVLEK AGKIAIQDWQ SNEVLGDDDV EIKIHTVGIC GSDVHYYQHG RIGPFVVDEP 70 80 90 100 110 120 MVLGHEASGV ITAAGKNVKH LKVGDRVCME PGIPDLQSPQ SRAGIYNLDP AVRFWATPPI 130 140 150 160 170 180 DGCLRESVIH PAAFTFKLPD NVSFAQGAMV EPLAIGMQSA TKAGIKPGDI GLVIGAGTIG 190 200 210 220 230 240 IITQSALAGG CSDVIICDVF DEKLKVAEKY QGLHAVNSKD QQALADKVRE LTGGEGVNVL 250 260 270 280 290 300 FECSGAKPVI ASISDHIAPG GTAVLVGMPI DPAPLDIVAA QAKEVTFKTI LRYANMYPRT 310 320 330 IRLLSSGKLN VAPLLSATYK FKDSVEAYER AAEPVRLM

References

[1]	"Molecular characterization of xylitol catabolic pathways in the Enterobacteriaceae." Gallo M.A., Mortlock R.P. Thesis (1991), University of Wisconsin-Madison, United States Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 25829 / DSM 6675 / NCTC 417.
[2]	"Inducible xylitol dehydrogenases in enteric bacteria." Doten R.C., Mortlock R.P. J. Bacteriol. 162:845-848(1985) [PubMed: 3886639] [Abstract] Cited for: CHARACTERIZATION. Strain: ATCC 25829 / DSM 6675 / NCTC 417.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L34345 Genomic DNA. Translation: AAA25324.1.
3D structure databases
HSSP	HSSP built from PDB template 1E3J based on UniProtKB O96496.
ModBase	Search...
Enzyme and pathway databases
BioCyc	MetaCyc:MON-12199.
BRENDA	1.1.1.9. 2621.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. IPR013149. ADH_Zn-bd. IPR002328. ADH_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
ProDom	PD040557. GroES_related. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLD_MORMO

Accession

Primary (citable) accession number: Q59545

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)