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Q59536

- PTRB_MORLA

UniProt

Q59536 - PTRB_MORLA

Protein

Protease 2

Gene

ptrB

Organism
Moraxella lacunata
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    • Comment

    Functioni

    Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues.

    Catalytic activityi

    Hydrolysis of -Arg-|-Xaa- and -Lys-|-Xaa- bonds in oligopeptides, even when P1' residue is proline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei534 – 5341Charge relay systemPROSITE-ProRule annotation
    Active sitei619 – 6191Charge relay systemPROSITE-ProRule annotation
    Active sitei654 – 6541Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. serine-type exopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protease 2 (EC:3.4.21.83)
    Alternative name(s):
    Oligopeptidase B
    Protease II
    Gene namesi
    Name:ptrB
    OrganismiMoraxella lacunata
    Taxonomic identifieri477 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 690690Protease 2PRO_0000122405Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ59536.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9A family.Curated

    Family and domain databases

    Gene3Di2.130.10.120. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR023302. Pept_S9A_N.
    IPR001375. Peptidase_S9.
    IPR002470. Peptidase_S9A.
    [Graphical view]
    PANTHERiPTHR11757. PTHR11757. 1 hit.
    PfamiPF00326. Peptidase_S9. 1 hit.
    PF02897. Peptidase_S9_N. 1 hit.
    [Graphical view]
    PRINTSiPR00862. PROLIGOPTASE.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q59536-1 [UniParc]FASTAAdd to Basket

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    MKLPIAKRIP HPHELHGDVR EDDYYWLKDR DNTEVIQYLE EENRYYHEIM    50
    RPLQEQTEQI YESMVDRVPD SEMKVPVQHG QFFYYSRLDK NKQYPIYARK 100
    QAASRALLQD ATEEVVLDLN ELAEEDDYLS VTVQRMTTDH SRLAYLENRD 150
    GTDRYTIYIK DLNTGELLSD RVPNVYIYGS MEWCRCGDYI FYTTVDEHQR 200
    PCQLWRHRLG SDVESDELIF EEKDDTFTLF ISKSQSGKFI FVYSSSKTTS 250
    EIHMIDTDSP LSPLQLVDER RDGILYDVEH WEDDLLILTN EGALNFQLLR 300
    CPLNDLSSKV NVVEYNEERY LQEMYPFRDK LLIAGRENGL TQIWVVHDGE 350
    LQQISWDEPL YTVAVLSEQS YDTNEVLIQY ESLLTPKTTF GLNLQTGEKQ 400
    CLQVAPVSGE YDRSQFRQEQ LWATGRSGVK VPMTAVYLEG ALDNGPAPLI 450
    LYGYGSYGSN SDPRFDPYRL PLLEKGIVFV TAQVRGGSEM GRGWYEDGKM 500
    QNKRNTFTDF IAAAKHLIDQ NYTSPTKMAA RGGSAGGLLV GAVANMAGEL 550
    FKVIVPAVPF VDVVTTMLDT SIPLTTLEWD EWGDPRKQED YFYMKSYSPY 600
    DNVEAKDYPH MYITTGINDP RVGYFEPAKW VARLRAVKTD NNTLVMKTNM 650
    GAGHFGKSGR FNHLKEAAES YAFILDKLGV EAEEKVLNHR 690
    Length:690
    Mass (Da):79,507
    Last modified:November 1, 1996 - v1
    Checksum:i5F2B7065EF44B4B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38405 Genomic DNA. Translation: BAA07460.1.
    PIRiJC4185.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38405 Genomic DNA. Translation: BAA07460.1 .
    PIRi JC4185.

    3D structure databases

    ProteinModelPortali Q59536.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.130.10.120. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002471. Pept_S9_AS.
    IPR023302. Pept_S9A_N.
    IPR001375. Peptidase_S9.
    IPR002470. Peptidase_S9A.
    [Graphical view ]
    PANTHERi PTHR11757. PTHR11757. 1 hit.
    Pfami PF00326. Peptidase_S9. 1 hit.
    PF02897. Peptidase_S9_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00862. PROLIGOPTASE.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protease II from Moraxella lacunata: cloning, sequencing, and expression of the enzyme gene, and crystallization of the expressed enzyme."
      Yoshimoto T., Tabira J., Kabashima T., Inoue S., Ito K.
      J. Biochem. 117:654-660(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPTRB_MORLA
    AccessioniPrimary (citable) accession number: Q59536
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3