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Q59536

- PTRB_MORLA

UniProt

Q59536 - PTRB_MORLA

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Protein
Protease 2
Gene
ptrB
Organism
Moraxella lacunata
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues.

Catalytic activityi

Hydrolysis of -Arg-|-Xaa- and -Lys-|-Xaa- bonds in oligopeptides, even when P1' residue is proline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei534 – 5341Charge relay system By similarity
Active sitei619 – 6191Charge relay system By similarity
Active sitei654 – 6541Charge relay system By similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type exopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease 2 (EC:3.4.21.83)
Alternative name(s):
Oligopeptidase B
Protease II
Gene namesi
Name:ptrB
OrganismiMoraxella lacunata
Taxonomic identifieri477 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 690690Protease 2
PRO_0000122405Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ59536.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9A family.

Family and domain databases

Gene3Di2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view]
PANTHERiPTHR11757. PTHR11757. 1 hit.
PfamiPF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view]
PRINTSiPR00862. PROLIGOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59536-1 [UniParc]FASTAAdd to Basket

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MKLPIAKRIP HPHELHGDVR EDDYYWLKDR DNTEVIQYLE EENRYYHEIM    50
RPLQEQTEQI YESMVDRVPD SEMKVPVQHG QFFYYSRLDK NKQYPIYARK 100
QAASRALLQD ATEEVVLDLN ELAEEDDYLS VTVQRMTTDH SRLAYLENRD 150
GTDRYTIYIK DLNTGELLSD RVPNVYIYGS MEWCRCGDYI FYTTVDEHQR 200
PCQLWRHRLG SDVESDELIF EEKDDTFTLF ISKSQSGKFI FVYSSSKTTS 250
EIHMIDTDSP LSPLQLVDER RDGILYDVEH WEDDLLILTN EGALNFQLLR 300
CPLNDLSSKV NVVEYNEERY LQEMYPFRDK LLIAGRENGL TQIWVVHDGE 350
LQQISWDEPL YTVAVLSEQS YDTNEVLIQY ESLLTPKTTF GLNLQTGEKQ 400
CLQVAPVSGE YDRSQFRQEQ LWATGRSGVK VPMTAVYLEG ALDNGPAPLI 450
LYGYGSYGSN SDPRFDPYRL PLLEKGIVFV TAQVRGGSEM GRGWYEDGKM 500
QNKRNTFTDF IAAAKHLIDQ NYTSPTKMAA RGGSAGGLLV GAVANMAGEL 550
FKVIVPAVPF VDVVTTMLDT SIPLTTLEWD EWGDPRKQED YFYMKSYSPY 600
DNVEAKDYPH MYITTGINDP RVGYFEPAKW VARLRAVKTD NNTLVMKTNM 650
GAGHFGKSGR FNHLKEAAES YAFILDKLGV EAEEKVLNHR 690
Length:690
Mass (Da):79,507
Last modified:November 1, 1996 - v1
Checksum:i5F2B7065EF44B4B8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38405 Genomic DNA. Translation: BAA07460.1.
PIRiJC4185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38405 Genomic DNA. Translation: BAA07460.1 .
PIRi JC4185.

3D structure databases

ProteinModelPortali Q59536.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S09.010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view ]
PANTHERi PTHR11757. PTHR11757. 1 hit.
Pfami PF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view ]
PRINTSi PR00862. PROLIGOPTASE.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Protease II from Moraxella lacunata: cloning, sequencing, and expression of the enzyme gene, and crystallization of the expressed enzyme."
    Yoshimoto T., Tabira J., Kabashima T., Inoue S., Ito K.
    J. Biochem. 117:654-660(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPTRB_MORLA
AccessioniPrimary (citable) accession number: Q59536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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