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Protein

Protease 2

Gene

ptrB

Organism
Moraxella lacunata
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues.

Catalytic activityi

Hydrolysis of -Arg-|-Xaa- and -Lys-|-Xaa- bonds in oligopeptides, even when P1' residue is proline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei534 – 5341Charge relay systemPROSITE-ProRule annotation
Active sitei619 – 6191Charge relay systemPROSITE-ProRule annotation
Active sitei654 – 6541Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.83. 9781.

Protein family/group databases

ESTHERimorla-ptrb. S9N_PREPL_Peptidase_S9.
MEROPSiS09.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Protease 2 (EC:3.4.21.83)
Alternative name(s):
Oligopeptidase B
Protease II
Gene namesi
Name:ptrB
OrganismiMoraxella lacunata
Taxonomic identifieri477 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 690690Protease 2PRO_0000122405Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ59536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9A family.Curated

Family and domain databases

Gene3Di2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view]
PANTHERiPTHR11757. PTHR11757. 1 hit.
PfamiPF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view]
PRINTSiPR00862. PROLIGOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59536-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPIAKRIP HPHELHGDVR EDDYYWLKDR DNTEVIQYLE EENRYYHEIM
60 70 80 90 100
RPLQEQTEQI YESMVDRVPD SEMKVPVQHG QFFYYSRLDK NKQYPIYARK
110 120 130 140 150
QAASRALLQD ATEEVVLDLN ELAEEDDYLS VTVQRMTTDH SRLAYLENRD
160 170 180 190 200
GTDRYTIYIK DLNTGELLSD RVPNVYIYGS MEWCRCGDYI FYTTVDEHQR
210 220 230 240 250
PCQLWRHRLG SDVESDELIF EEKDDTFTLF ISKSQSGKFI FVYSSSKTTS
260 270 280 290 300
EIHMIDTDSP LSPLQLVDER RDGILYDVEH WEDDLLILTN EGALNFQLLR
310 320 330 340 350
CPLNDLSSKV NVVEYNEERY LQEMYPFRDK LLIAGRENGL TQIWVVHDGE
360 370 380 390 400
LQQISWDEPL YTVAVLSEQS YDTNEVLIQY ESLLTPKTTF GLNLQTGEKQ
410 420 430 440 450
CLQVAPVSGE YDRSQFRQEQ LWATGRSGVK VPMTAVYLEG ALDNGPAPLI
460 470 480 490 500
LYGYGSYGSN SDPRFDPYRL PLLEKGIVFV TAQVRGGSEM GRGWYEDGKM
510 520 530 540 550
QNKRNTFTDF IAAAKHLIDQ NYTSPTKMAA RGGSAGGLLV GAVANMAGEL
560 570 580 590 600
FKVIVPAVPF VDVVTTMLDT SIPLTTLEWD EWGDPRKQED YFYMKSYSPY
610 620 630 640 650
DNVEAKDYPH MYITTGINDP RVGYFEPAKW VARLRAVKTD NNTLVMKTNM
660 670 680 690
GAGHFGKSGR FNHLKEAAES YAFILDKLGV EAEEKVLNHR
Length:690
Mass (Da):79,507
Last modified:November 1, 1996 - v1
Checksum:i5F2B7065EF44B4B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38405 Genomic DNA. Translation: BAA07460.1.
PIRiJC4185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38405 Genomic DNA. Translation: BAA07460.1.
PIRiJC4185.

3D structure databases

ProteinModelPortaliQ59536.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERimorla-ptrb. S9N_PREPL_Peptidase_S9.
MEROPSiS09.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.4.21.83. 9781.

Family and domain databases

Gene3Di2.130.10.120. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002471. Pept_S9_AS.
IPR023302. Pept_S9A_N.
IPR001375. Peptidase_S9.
IPR002470. Peptidase_S9A.
[Graphical view]
PANTHERiPTHR11757. PTHR11757. 1 hit.
PfamiPF00326. Peptidase_S9. 1 hit.
PF02897. Peptidase_S9_N. 1 hit.
[Graphical view]
PRINTSiPR00862. PROLIGOPTASE.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00708. PRO_ENDOPEP_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Protease II from Moraxella lacunata: cloning, sequencing, and expression of the enzyme gene, and crystallization of the expressed enzyme."
    Yoshimoto T., Tabira J., Kabashima T., Inoue S., Ito K.
    J. Biochem. 117:654-660(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPTRB_MORLA
AccessioniPrimary (citable) accession number: Q59536
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.