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Protein

RNA polymerase sigma factor SigA

Gene

rpoT

Organism
Mycobacterium leprae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi535 – 554H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, Sigma factorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Gene namesi
Name:rpoTImported
Synonyms:sigAUniRule annotation
OrganismiMycobacterium lepraeImported
Taxonomic identifieri1769 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Organism-specific databases

LepromaiML1022

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ59532
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini365 – 378RNA_pol_sigma70InterPro annotationAdd BLAST14
Domaini534 – 560RNA_pol_sigma70InterPro annotationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni341 – 411Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni420 – 496Sigma-70 factor domain-3UniRule annotationAdd BLAST77
Regioni509 – 562Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi365 – 368Interaction with polymerase core subunit RpoCUniRule annotation4

Phylogenomic databases

eggNOGiENOG4105DG1 Bacteria
COG0568 LUCA
HOGENOMiHOG000270273

Family and domain databases

Gene3Di1.10.10.10, 2 hits
HAMAPiMF_00963 Sigma70_RpoD_SigA, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR012760 RNA_pol_sigma_RpoD_C
IPR028630 Sigma70_RpoD
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02393 RpoD_Cterm, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit
PS00716 SIGMA70_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q59532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSRRVPPL QWLSAVARPI ARVLTLISTP TFDIADTFGY ACPNPPEVSP
60 70 80 90 100
TEGVYVVATK TSPATGQPVK RTATKTPATP AKRSTTKAAN GSAPTKRATS
110 120 130 140 150
TASRATKSTT PPKASGASDA AKKARTSVKS VDTKAPSAQD HTTKASAAKD
160 170 180 190 200
TLNDPEATLN TLDSDATADD LDAEPDLDVE PSEDIDIDIE AADLGLDDLE
210 220 230 240 250
DDDVVTDIEP GETEDGEATA ATKTDEASTD DDEEIVEPTE KDKASGDFVW
260 270 280 290 300
DEDESEALRQ ARKDAELTAS ADSVRAYLKQ IGKVALLNAE EEVELAKRIE
310 320 330 340 350
AGLYATQLMT ELSERGTKLP TAQRRDMMWI CRDGDRAKNH LLEANLRLVV
360 370 380 390 400
SLAKRYTGRG MAFLDLIQEG NLGLIRAVEK FDYTKGYKFS TYATWWIRQA
410 420 430 440 450
ITRAMADQAR TIRIPVHMVE VINKLGRIQR ELLQDLGREP TPEELAKEMD
460 470 480 490 500
ITPEKVLEIQ QYAREPISLD QTIGDEGDSQ LGDFIEDSEA VVAVDAVSFT
510 520 530 540 550
LLQDQLQSVL ETLSEREAGV VRLRFGLTDG QPRTLDEIGQ VYGVTRERIR
560 570
QIESKTMSKL RHPSRSQVLR DYLD
Length:574
Mass (Da):63,038
Last modified:November 1, 1996 - v1
Checksum:i9006DCFAFBB32658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15181 Genomic DNA Translation: AAA62955.1
AB019193 Genomic DNA Translation: BAA76621.1
PIRiH87036

Similar proteinsi

Entry informationi

Entry nameiQ59532_MYCLR
AccessioniPrimary (citable) accession number: Q59532
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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