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Protein

RNA polymerase sigma factor SigA

Gene

rpoT

Organism
Mycobacterium leprae
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi535 – 554H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Sigma factorUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor SigAUniRule annotation
Gene namesi
Name:rpoTImported
Synonyms:sigAUniRule annotation
OrganismiMycobacterium lepraeImported
Taxonomic identifieri1769 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Organism-specific databases

LepromaiML1022.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Interacts transiently with the RNA polymerase catalytic core.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1022.

Structurei

3D structure databases

ProteinModelPortaliQ59532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini365 – 378RNA_pol_sigma70InterPro annotationAdd BLAST14
Domaini534 – 560RNA_pol_sigma70InterPro annotationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni341 – 411Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni420 – 496Sigma-70 factor domain-3UniRule annotationAdd BLAST77
Regioni509 – 562Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi365 – 368Interaction with polymerase core subunit RpoCUniRule annotation4

Phylogenomic databases

eggNOGiENOG4105DG1. Bacteria.
COG0568. LUCA.
HOGENOMiHOG000270273.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00963. Sigma70_RpoD_SigA. 1 hit.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR028630. Sigma70_RpoD.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02393. RpoD_Cterm. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQSRRVPPL QWLSAVARPI ARVLTLISTP TFDIADTFGY ACPNPPEVSP
60 70 80 90 100
TEGVYVVATK TSPATGQPVK RTATKTPATP AKRSTTKAAN GSAPTKRATS
110 120 130 140 150
TASRATKSTT PPKASGASDA AKKARTSVKS VDTKAPSAQD HTTKASAAKD
160 170 180 190 200
TLNDPEATLN TLDSDATADD LDAEPDLDVE PSEDIDIDIE AADLGLDDLE
210 220 230 240 250
DDDVVTDIEP GETEDGEATA ATKTDEASTD DDEEIVEPTE KDKASGDFVW
260 270 280 290 300
DEDESEALRQ ARKDAELTAS ADSVRAYLKQ IGKVALLNAE EEVELAKRIE
310 320 330 340 350
AGLYATQLMT ELSERGTKLP TAQRRDMMWI CRDGDRAKNH LLEANLRLVV
360 370 380 390 400
SLAKRYTGRG MAFLDLIQEG NLGLIRAVEK FDYTKGYKFS TYATWWIRQA
410 420 430 440 450
ITRAMADQAR TIRIPVHMVE VINKLGRIQR ELLQDLGREP TPEELAKEMD
460 470 480 490 500
ITPEKVLEIQ QYAREPISLD QTIGDEGDSQ LGDFIEDSEA VVAVDAVSFT
510 520 530 540 550
LLQDQLQSVL ETLSEREAGV VRLRFGLTDG QPRTLDEIGQ VYGVTRERIR
560 570
QIESKTMSKL RHPSRSQVLR DYLD
Length:574
Mass (Da):63,038
Last modified:November 1, 1996 - v1
Checksum:i9006DCFAFBB32658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15181 Genomic DNA. Translation: AAA62955.1.
AB019193 Genomic DNA. Translation: BAA76621.1.
PIRiH87036.

Genome annotation databases

PATRICi18053812. VBIMycLep78757_1851.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15181 Genomic DNA. Translation: AAA62955.1.
AB019193 Genomic DNA. Translation: BAA76621.1.
PIRiH87036.

3D structure databases

ProteinModelPortaliQ59532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICi18053812. VBIMycLep78757_1851.

Organism-specific databases

LepromaiML1022.

Phylogenomic databases

eggNOGiENOG4105DG1. Bacteria.
COG0568. LUCA.
HOGENOMiHOG000270273.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00963. Sigma70_RpoD_SigA. 1 hit.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012760. RNA_pol_sigma_RpoD_C.
IPR028630. Sigma70_RpoD.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02393. RpoD_Cterm. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ59532_MYCLR
AccessioniPrimary (citable) accession number: Q59532
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.