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Protein

RNA polymerase sigma factor

Gene

ML1014

Organism
Mycobacterium leprae (strain TN)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Sigma factorUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factorUniRule annotation
Gene namesi
Ordered Locus Names:ML1014Imported
OrganismiMycobacterium leprae (strain TN)Imported
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1014.

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1014.

Structurei

3D structure databases

ProteinModelPortaliQ59531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 123RNA_pol_sigma70InterPro annotationAdd BLAST14
Domaini279 – 305RNA_pol_sigma70InterPro annotationAdd BLAST27

Sequence similaritiesi

Belongs to the sigma-70 factor family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DG1. Bacteria.
COG0568. LUCA.
HOGENOMiHOG000270273.
KOiK03087.
OMAiHTDIRYV.
OrthoDBiPOG091H0012.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q59531-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEATTNRVD SDLDAQSPAA DLVRVYLNGI GKTALLNAAD EVELAKRIEA
60 70 80 90 100
GLYAEHLLQT RKRFGEGRKR ALAAVARDGA AARRHLLEAN LRLVVSLAKR
110 120 130 140 150
YTGRGMPLLD LIQEGNLGLI RAMEKFDYTK GFKFSTYATW WIRQAITRGM
160 170 180 190 200
ADQSRTIRLP VHLVEQVNKL ARIKREMHQN LGREATDEEL AAESGIPIEK
210 220 230 240 250
INDLLEHSRD PVSLDMPVGS EEEAPLGDFI EDAEAMSAEN AVIAELLHTD
260 270 280 290 300
IRSVLATLDE REHQVIRLRF GLDDGQPRTL DQIGKLFGLS RERVRQIERD
310
VMCKLRNGER ADRLRSYAS
Length:319
Mass (Da):35,847
Last modified:November 1, 1996 - v1
Checksum:iF76F45186D4BA477
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583920 Genomic DNA. Translation: CAC31395.1.
PIRiH87035.
RefSeqiNP_301750.1. NC_002677.1.
WP_010908074.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31395; CAC31395; CAC31395.
GeneIDi910072.
KEGGimle:ML1014.
PATRICi18053798. VBIMycLep78757_1844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL583920 Genomic DNA. Translation: CAC31395.1.
PIRiH87035.
RefSeqiNP_301750.1. NC_002677.1.
WP_010908074.1. NC_002677.1.

3D structure databases

ProteinModelPortaliQ59531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31395; CAC31395; CAC31395.
GeneIDi910072.
KEGGimle:ML1014.
PATRICi18053798. VBIMycLep78757_1844.

Organism-specific databases

LepromaiML1014.

Phylogenomic databases

eggNOGiENOG4105DG1. Bacteria.
COG0568. LUCA.
HOGENOMiHOG000270273.
KOiK03087.
OMAiHTDIRYV.
OrthoDBiPOG091H0012.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
PS00716. SIGMA70_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ59531_MYCLE
AccessioniPrimary (citable) accession number: Q59531
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 5, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.