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Q59514

- BLA1_MORCA

UniProt

Q59514 - BLA1_MORCA

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Protein

Beta-lactamase BRO-1

Gene

bla

Organism
Moraxella catarrhalis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901Acyl-ester intermediateBy similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC

GO - Biological processi

  1. beta-lactam antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKQ59514.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase BRO-1 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
OrganismiMoraxella catarrhalis
Taxonomic identifieri480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525PROSITE-ProRule annotationAdd
BLAST
Chaini26 – 313288Beta-lactamase BRO-1PRO_0000017002Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi26 – 261N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi26 – 261S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliQ59514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni255 – 2573Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59514-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRRHFLQKT LLALPIIFSG NLLTGCKTNL SDDYLPDDKI TNNPNLLQNK
60 70 80 90 100
LKEILPIWEN KFNAKIGMTI IADNGELSSH RGNEYFPVNS TIKAFIASHI
110 120 130 140 150
LLLVDKEKLD LNEKIIIKES DLIEYSPVCK KYFDENKPIS ISELCEATIT
160 170 180 190 200
LSDNGSANIL LDKIGGLTAF NQFLKEIGAD MVLANNEPLL NRSHYGETSD
210 220 230 240 250
TAKPIPYTKS LKALIVGNIL SNQSKEQLIT WLINDKVADN LLRKYLPKNW
260 270 280 290 300
RIGDKTGTGS ESKNIIAVIW NENNKPYFIS LFITQPHDGK SLDFKNQKDE
310
IMAQIGKEIY PFL
Length:313
Mass (Da):35,383
Last modified:November 1, 1997 - v1
Checksum:iA673AF8FBAB02840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49269 Genomic DNA. Translation: AAA92126.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49269 Genomic DNA. Translation: AAA92126.1 .

3D structure databases

ProteinModelPortali Q59514.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL1744491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK Q59514.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view ]
PRINTSi PR00118. BLACTAMASEA.
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Moraxella (Branhamella) catarrhalis chromosomal beta-lactamase gene is flanked by an amidase gene and a conserved gene of unknown function."
    Beaulieu D., Piche L., Parr T.R. Jr., Roeger-Lawry K., Rosteck P., Roy P.H.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 53879 / E22.

Entry informationi

Entry nameiBLA1_MORCA
AccessioniPrimary (citable) accession number: Q59514
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3