Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-lactamase BRO-1

Gene

bla

Organism
Moraxella catarrhalis (Branhamella catarrhalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei90Acyl-ester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKQ59514.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase BRO-1 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
OrganismiMoraxella catarrhalis (Branhamella catarrhalis)
Taxonomic identifieri480 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1744491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25PROSITE-ProRule annotationAdd BLAST25
ChainiPRO_000001700226 – 313Beta-lactamase BRO-1Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi26N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi26S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliQ59514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni255 – 257Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108J4B. Bacteria.
COG2367. LUCA.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q59514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRRHFLQKT LLALPIIFSG NLLTGCKTNL SDDYLPDDKI TNNPNLLQNK
60 70 80 90 100
LKEILPIWEN KFNAKIGMTI IADNGELSSH RGNEYFPVNS TIKAFIASHI
110 120 130 140 150
LLLVDKEKLD LNEKIIIKES DLIEYSPVCK KYFDENKPIS ISELCEATIT
160 170 180 190 200
LSDNGSANIL LDKIGGLTAF NQFLKEIGAD MVLANNEPLL NRSHYGETSD
210 220 230 240 250
TAKPIPYTKS LKALIVGNIL SNQSKEQLIT WLINDKVADN LLRKYLPKNW
260 270 280 290 300
RIGDKTGTGS ESKNIIAVIW NENNKPYFIS LFITQPHDGK SLDFKNQKDE
310
IMAQIGKEIY PFL
Length:313
Mass (Da):35,383
Last modified:November 1, 1997 - v1
Checksum:iA673AF8FBAB02840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49269 Genomic DNA. Translation: AAA92126.1.
RefSeqiWP_003657002.1. NZ_LZDK01000008.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49269 Genomic DNA. Translation: AAA92126.1.
RefSeqiWP_003657002.1. NZ_LZDK01000008.1.

3D structure databases

ProteinModelPortaliQ59514.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL1744491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4108J4B. Bacteria.
COG2367. LUCA.

Enzyme and pathway databases

SABIO-RKQ59514.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBLA1_MORCA
AccessioniPrimary (citable) accession number: Q59514
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.