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Q59514

- BLA1_MORCA

UniProt

Q59514 - BLA1_MORCA

Protein

Beta-lactamase BRO-1

Gene

bla

Organism
Moraxella catarrhalis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei90 – 901Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC

    GO - Biological processi

    1. beta-lactam antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    SABIO-RKQ59514.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase BRO-1 (EC:3.5.2.6)
    Alternative name(s):
    Penicillinase
    Gene namesi
    Name:bla
    OrganismiMoraxella catarrhalis
    Taxonomic identifieri480 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525PROSITE-ProRule annotationAdd
    BLAST
    Chaini26 – 313288Beta-lactamase BRO-1PRO_0000017002Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi26 – 261N-palmitoyl cysteinePROSITE-ProRule annotation
    Lipidationi26 – 261S-diacylglycerol cysteinePROSITE-ProRule annotation

    Keywords - PTMi

    Lipoprotein, Palmitate

    Structurei

    3D structure databases

    ProteinModelPortaliQ59514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni255 – 2573Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-A beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    [Graphical view]
    PRINTSiPR00118. BLACTAMASEA.
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q59514-1 [UniParc]FASTAAdd to Basket

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    MQRRHFLQKT LLALPIIFSG NLLTGCKTNL SDDYLPDDKI TNNPNLLQNK    50
    LKEILPIWEN KFNAKIGMTI IADNGELSSH RGNEYFPVNS TIKAFIASHI 100
    LLLVDKEKLD LNEKIIIKES DLIEYSPVCK KYFDENKPIS ISELCEATIT 150
    LSDNGSANIL LDKIGGLTAF NQFLKEIGAD MVLANNEPLL NRSHYGETSD 200
    TAKPIPYTKS LKALIVGNIL SNQSKEQLIT WLINDKVADN LLRKYLPKNW 250
    RIGDKTGTGS ESKNIIAVIW NENNKPYFIS LFITQPHDGK SLDFKNQKDE 300
    IMAQIGKEIY PFL 313
    Length:313
    Mass (Da):35,383
    Last modified:November 1, 1997 - v1
    Checksum:iA673AF8FBAB02840
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49269 Genomic DNA. Translation: AAA92126.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U49269 Genomic DNA. Translation: AAA92126.1 .

    3D structure databases

    ProteinModelPortali Q59514.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL1744491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK Q59514.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR000871. Beta-lactam_class-A/D.
    [Graphical view ]
    PRINTSi PR00118. BLACTAMASEA.
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Moraxella (Branhamella) catarrhalis chromosomal beta-lactamase gene is flanked by an amidase gene and a conserved gene of unknown function."
      Beaulieu D., Piche L., Parr T.R. Jr., Roeger-Lawry K., Rosteck P., Roy P.H.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 53879 / E22.

    Entry informationi

    Entry nameiBLA1_MORCA
    AccessioniPrimary (citable) accession number: Q59514
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3