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Q59514 (BLA1_MORCA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-lactamase BRO-1

EC=3.5.2.6
Alternative name(s):
Penicillinase
Gene names
Name:bla
OrganismMoraxella catarrhalis
Taxonomic identifier480 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeMoraxella

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Subcellular location

Cell membrane; Lipid-anchor Probable.

Sequence similarities

Belongs to the class-A beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Cellular componentCell membrane
Membrane
   DomainSignal
   Molecular functionHydrolase
   PTMLipoprotein
Palmitate
Gene Ontology (GO)
   Biological_processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 313288Beta-lactamase BRO-1
PRO_0000017002

Regions

Region255 – 2573Substrate binding By similarity

Sites

Active site901Acyl-ester intermediate By similarity

Amino acid modifications

Lipidation261N-palmitoyl cysteine Potential
Lipidation261S-diacylglycerol cysteine Potential

Sequences

Sequence LengthMass (Da)Tools
Q59514 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: A673AF8FBAB02840

FASTA31335,383
        10         20         30         40         50         60 
MQRRHFLQKT LLALPIIFSG NLLTGCKTNL SDDYLPDDKI TNNPNLLQNK LKEILPIWEN 

        70         80         90        100        110        120 
KFNAKIGMTI IADNGELSSH RGNEYFPVNS TIKAFIASHI LLLVDKEKLD LNEKIIIKES 

       130        140        150        160        170        180 
DLIEYSPVCK KYFDENKPIS ISELCEATIT LSDNGSANIL LDKIGGLTAF NQFLKEIGAD 

       190        200        210        220        230        240 
MVLANNEPLL NRSHYGETSD TAKPIPYTKS LKALIVGNIL SNQSKEQLIT WLINDKVADN 

       250        260        270        280        290        300 
LLRKYLPKNW RIGDKTGTGS ESKNIIAVIW NENNKPYFIS LFITQPHDGK SLDFKNQKDE 

       310 
IMAQIGKEIY PFL 

« Hide

References

[1]"The Moraxella (Branhamella) catarrhalis chromosomal beta-lactamase gene is flanked by an amidase gene and a conserved gene of unknown function."
Beaulieu D., Piche L., Parr T.R. Jr., Roeger-Lawry K., Rosteck P., Roy P.H.
Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 53879 / E22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U49269 Genomic DNA. Translation: AAA92126.1.

3D structure databases

ProteinModelPortalQ59514.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL1744491.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKQ59514.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. SSF56601. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLA1_MORCA
AccessionPrimary (citable) accession number: Q59514
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 11, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families