Reviewed, UniProtKB/Swiss-Prot Q59477 (DHAT_KLEPN)

Names and origin

Protein names

Recommended name:
    1,3-propanediol dehydrogenase
    EC=1.1.1.202
Alternative name(s):
    3-hydroxypropionaldehyde reductase
    1,3-propanediol oxidoreductase

Gene names

Name:

dhaT

Organism

Klebsiella pneumoniae

Taxonomic identifier

573 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH.
Cofactor	Iron By similarity.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the iron-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Iron NAD
Molecular function	Oxidoreductase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1,3-propanediol dehydrogenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	1,3-propanediol dehydrogenase		PRO_0000087842

Sequences

	Sequence		Length	Mass (Da)
	Q59477-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 37E7BD4CDF2EC409	FASTA	387	41,466
	10 20 30 40 50 60 MSYRMFDYLV PNVNFFGPNA ISVVGERCQL LGGKKALLVT DKGLRAIKDG AVDKTLHYLR 70 80 90 100 110 120 EAGIEVAIFD GVEPNPKDTN VRDGLAVFRR EQCDIIVTVG GGSPHDCGKG IGIAATHEGD 130 140 150 160 170 180 LYQYAGIETL TNPLPPIVAV NTTAGTASEV TRHCVLTNTE TKVKFVIVSW RNLPSVSIND 190 200 210 220 230 240 PLLMIGKPAA LTAATGMDAL THAVEAYISK DANPVTDAAA MQAIRLIARN LRQAVALGSN 250 260 270 280 290 300 LQARENMAYA SLLAGMAFNN ANLGYVHAMA HQLGGLYDMP HGVANAVLLP HVARYNLIAN 310 320 330 340 350 360 PEKFADIAEL MGENITGLST LDAAEKAIAA ITRLSMDIGI PQHLRDLGVK EADFPYMAEM 370 380 ALKDGNAFSN PRKGNEQEIA AIFRQAF

References

[1]	Skraly F.A., Willard B.L., Cameron D.C. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 25955.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

U30903 Genomic DNA. Translation: AAA74260.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3BFJ	X-ray	2.70	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T	1-387	[»]

ModBase

Search...

Enzyme and pathway databases

BRENDA

1.1.1.202. 758.
1.1.1.31. 403.

Family and domain databases

InterPro

IPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]

Pfam

PF00465. Fe-ADH. 1 hit.
[Graphical view]

PROSITE

PS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

DHAT_KLEPN

Accession

Primary (citable) accession number: Q59477

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)