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Q59472

- Q59472_KLEOX

UniProt

Q59472 - Q59472_KLEOX

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Protein
Submitted name:

Diol dehydrase gamma subunit

Gene

pddC

Organism
Klebsiella oxytoca
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. propanediol dehydratase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Diol dehydrase gamma subunitImported (EC:4.2.1.28Imported)
Submitted name:
Propanediol dehydrataseImported
Gene namesi
Name:pddCImported
Synonyms:pduEImported
ORF Names:FF19_11650Imported, HR38_27600Imported
OrganismiKlebsiella oxytocaImported
Taxonomic identifieri571 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000027606: Genome

Interactioni

Protein-protein interaction databases

MINTiMINT-7997129.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DIOX-ray2.20G/M1-173[»]
1EEXX-ray1.70G/M1-173[»]
1EGMX-ray1.85G/M1-173[»]
1EGVX-ray1.75G/M1-173[»]
1IWBX-ray1.85G/M1-173[»]
1UC4X-ray1.80G/M1-173[»]
1UC5X-ray2.30G/M1-173[»]
3AUJX-ray2.10G/M1-173[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ59472.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 773Phosphate 1 bindingImported
Regioni75 – 773Phosphate 2 bindingImported

Phylogenomic databases

KOiK13920.

Family and domain databases

InterProiIPR003207. Ppandiol/glycerol_DeHydtase_su.
[Graphical view]
PfamiPF02287. Dehydratase_SU. 1 hit.
[Graphical view]
PIRSFiPIRSF018505. Prpndl_dhdrts_sm. 1 hit.
SUPFAMiSSF47148. SSF47148. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59472-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTDAIESMV RDVLSRMNSL QGEAPAAAPA AGGASRSARV SDYPLANKHP
60 70 80 90 100
EWVKTATNKT LDDFTLENVL SNKVTAQDMR ITPETLRLQA SIAKDAGRDR
110 120 130 140 150
LAMNFERAAE LTAVPDDRIL EIYNALRPYR STKEELLAIA DDLESRYQAK
160 170
ICAAFVREAA TLYVERKKLK GDD
Length:173
Mass (Da):19,173
Last modified:November 1, 1996 - v1
Checksum:i0B8602E39B38ECD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP008841 Genomic DNA. Translation: AIE72072.1.
D45071 Genomic DNA. Translation: BAA08101.1.
JNCH01000030 Genomic DNA. Translation: KFC40964.1.
PIRiC56111.
RefSeqiYP_005016277.1. NC_016612.1.

Genome annotation databases

GeneIDi11660427.
KEGGikox:KOX_01465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP008841 Genomic DNA. Translation: AIE72072.1 .
D45071 Genomic DNA. Translation: BAA08101.1 .
JNCH01000030 Genomic DNA. Translation: KFC40964.1 .
PIRi C56111.
RefSeqi YP_005016277.1. NC_016612.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DIO X-ray 2.20 G/M 1-173 [» ]
1EEX X-ray 1.70 G/M 1-173 [» ]
1EGM X-ray 1.85 G/M 1-173 [» ]
1EGV X-ray 1.75 G/M 1-173 [» ]
1IWB X-ray 1.85 G/M 1-173 [» ]
1UC4 X-ray 1.80 G/M 1-173 [» ]
1UC5 X-ray 2.30 G/M 1-173 [» ]
3AUJ X-ray 2.10 G/M 1-173 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-7997129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11660427.
KEGGi kox:KOX_01465.

Phylogenomic databases

KOi K13920.

Miscellaneous databases

EvolutionaryTracei Q59472.

Family and domain databases

InterProi IPR003207. Ppandiol/glycerol_DeHydtase_su.
[Graphical view ]
Pfami PF02287. Dehydratase_SU. 1 hit.
[Graphical view ]
PIRSFi PIRSF018505. Prpndl_dhdrts_sm. 1 hit.
SUPFAMi SSF47148. SSF47148. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, sequencing, and expression of the genes encoding adenosylcobalamin-dependent diol dehydrase of Klebsiella oxytoca."
    Tobimatsu T., Hara T., Sakaguchi M., Kishimoto Y., Wada Y., Isoda M., Sakai T., Toraya T.
    J. Biol. Chem. 270:7142-7148(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 8724Imported.
  2. "A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis: X-ray structure of diol dehydratase."
    Shibata N., Masuda J., Tobimatsu T., Toraya T., Suto K., Morimoto Y., Yasuoka N.
    Structure 7:997-1008(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).
  3. "How a protein generates a catalytic radical from coenzyme B(12): X-ray structure of a diol-dehydratase-adeninylpentylcobalamin complex."
    Masuda J., Shibata N., Morimoto Y., Toraya T., Yasuoka N.
    Structure 8:775-788(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
  4. "Substrate-induced conformational change of a coenzyme B12-dependent enzyme: crystal structure of the substrate-free form of diol dehydratase."
    Shibata N., Masuda J., Morimoto Y., Yasuoka N., Toraya T.
    Biochemistry 41:12607-12617(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
  5. "Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase."
    Shibata N., Nakanishi Y., Fukuoka M., Yamanishi M., Yasuoka N., Toraya T.
    J. Biol. Chem. 278:22717-22725(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
  6. "Redesign of coenzyme B(12) dependent diol dehydratase to be resistant to the mechanism-based inactivation by glycerol and act on longer chain 1,2-diols."
    Yamanishi M., Kinoshita K., Fukuoka M., Saito T., Tanokuchi A., Ikeda Y., Obayashi H., Mori K., Shibata N., Tobimatsu T., Toraya T.
    FEBS J. 279:793-804(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
  7. "Genome sequencing of Klebsiella oxytoca r8a."
    Chan K.-G., Goh S.Y.
    Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: R8AImported.
  8. "Whole Genome Sequence of Klebsiella oxytoca M1."
    Shin S.H., Um Y., Cho S., Kim J., Roh H., Yang K.-S.
    Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: M1Imported.

Entry informationi

Entry nameiQ59472_KLEOX
AccessioniPrimary (citable) accession number: Q59472
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3