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Q59472

- Q59472_KLEOX

UniProt

Q59472 - Q59472_KLEOX

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Protein
Submitted name: Diol dehydrase gamma subunit
Gene
pddC
Organism
Klebsiella oxytoca
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. propanediol dehydratase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Diol dehydrase gamma subunitImported (EC:4.2.1.28Imported)
Gene namesi
Name:pddCImported
OrganismiKlebsiella oxytocaImported
Taxonomic identifieri571 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Interactioni

Protein-protein interaction databases

IntActiQ59472. 2 interactions.
MINTiMINT-7997129.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DIOX-ray2.20G/M1-173[»]
1EEXX-ray1.70G/M1-173[»]
1EGMX-ray1.85G/M1-173[»]
1EGVX-ray1.75G/M1-173[»]
1IWBX-ray1.85G/M1-173[»]
1UC4X-ray1.80G/M1-173[»]
1UC5X-ray2.30G/M1-173[»]
3AUJX-ray2.10G/M1-173[»]
ProteinModelPortaliQ59472.
SMRiQ59472. Positions 37-173.

Miscellaneous databases

EvolutionaryTraceiQ59472.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 773Phosphate 1 bindingImported
Regioni75 – 773Phosphate 2 bindingImported

Phylogenomic databases

KOiK13920.

Family and domain databases

InterProiIPR003207. Ppandiol/glycerol_DeHydtase_su.
[Graphical view]
PfamiPF02287. Dehydratase_SU. 1 hit.
[Graphical view]
PIRSFiPIRSF018505. Prpndl_dhdrts_sm. 1 hit.
SUPFAMiSSF47148. SSF47148. 1 hit.

Sequencei

Sequence statusi: Complete.

Q59472-1 [UniParc]FASTAAdd to Basket

« Hide

MNTDAIESMV RDVLSRMNSL QGEAPAAAPA AGGASRSARV SDYPLANKHP    50
EWVKTATNKT LDDFTLENVL SNKVTAQDMR ITPETLRLQA SIAKDAGRDR 100
LAMNFERAAE LTAVPDDRIL EIYNALRPYR STKEELLAIA DDLESRYQAK 150
ICAAFVREAA TLYVERKKLK GDD 173
Length:173
Mass (Da):19,173
Last modified:November 1, 1996 - v1
Checksum:i0B8602E39B38ECD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45071 Genomic DNA. Translation: BAA08101.1.
PIRiC56111.
RefSeqiYP_005016277.1. NC_016612.1.

Genome annotation databases

GeneIDi11660427.
KEGGikox:KOX_01465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D45071 Genomic DNA. Translation: BAA08101.1 .
PIRi C56111.
RefSeqi YP_005016277.1. NC_016612.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DIO X-ray 2.20 G/M 1-173 [» ]
1EEX X-ray 1.70 G/M 1-173 [» ]
1EGM X-ray 1.85 G/M 1-173 [» ]
1EGV X-ray 1.75 G/M 1-173 [» ]
1IWB X-ray 1.85 G/M 1-173 [» ]
1UC4 X-ray 1.80 G/M 1-173 [» ]
1UC5 X-ray 2.30 G/M 1-173 [» ]
3AUJ X-ray 2.10 G/M 1-173 [» ]
ProteinModelPortali Q59472.
SMRi Q59472. Positions 37-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q59472. 2 interactions.
MINTi MINT-7997129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 11660427.
KEGGi kox:KOX_01465.

Phylogenomic databases

KOi K13920.

Miscellaneous databases

EvolutionaryTracei Q59472.

Family and domain databases

InterProi IPR003207. Ppandiol/glycerol_DeHydtase_su.
[Graphical view ]
Pfami PF02287. Dehydratase_SU. 1 hit.
[Graphical view ]
PIRSFi PIRSF018505. Prpndl_dhdrts_sm. 1 hit.
SUPFAMi SSF47148. SSF47148. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, sequencing, and expression of the genes encoding adenosylcobalamin-dependent diol dehydrase of Klebsiella oxytoca."
    Tobimatsu T., Hara T., Sakaguchi M., Kishimoto Y., Wada Y., Isoda M., Sakai T., Toraya T.
    J. Biol. Chem. 270:7142-7148(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 8724Imported.
  2. "A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis: X-ray structure of diol dehydratase."
    Shibata N., Masuda J., Tobimatsu T., Toraya T., Suto K., Morimoto Y., Yasuoka N.
    Structure 7:997-1008(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).
  3. "How a protein generates a catalytic radical from coenzyme B(12): X-ray structure of a diol-dehydratase-adeninylpentylcobalamin complex."
    Masuda J., Shibata N., Morimoto Y., Toraya T., Yasuoka N.
    Structure 8:775-788(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
  4. "Substrate-induced conformational change of a coenzyme B12-dependent enzyme: crystal structure of the substrate-free form of diol dehydratase."
    Shibata N., Masuda J., Morimoto Y., Yasuoka N., Toraya T.
    Biochemistry 41:12607-12617(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
  5. "Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase."
    Shibata N., Nakanishi Y., Fukuoka M., Yamanishi M., Yasuoka N., Toraya T.
    J. Biol. Chem. 278:22717-22725(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
  6. "Redesign of coenzyme B(12) dependent diol dehydratase to be resistant to the mechanism-based inactivation by glycerol and act on longer chain 1,2-diols."
    Yamanishi M., Kinoshita K., Fukuoka M., Saito T., Tanokuchi A., Ikeda Y., Obayashi H., Mori K., Shibata N., Tobimatsu T., Toraya T.
    FEBS J. 279:793-804(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH PHOSPHATE.

Entry informationi

Entry nameiQ59472_KLEOX
AccessioniPrimary (citable) accession number: Q59472
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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