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Q59472

- Q59472_KLEOX

UniProt

Q59472 - Q59472_KLEOX

Protein
Submitted name:

Diol dehydrase gamma subunit

Gene

pddC

Organism
Klebsiella oxytoca
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. propanediol dehydratase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    LyaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Diol dehydrase gamma subunitImported (EC:4.2.1.28Imported)
    Submitted name:
    Propanediol dehydrataseImported
    Gene namesi
    Name:pddCImported
    Synonyms:pduEImported
    ORF Names:HR38_27600Imported
    OrganismiKlebsiella oxytocaImported
    Taxonomic identifieri571 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000027606: Genome

    Interactioni

    Protein-protein interaction databases

    IntActiQ59472. 2 interactions.
    MINTiMINT-7997129.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DIOX-ray2.20G/M1-173[»]
    1EEXX-ray1.70G/M1-173[»]
    1EGMX-ray1.85G/M1-173[»]
    1EGVX-ray1.75G/M1-173[»]
    1IWBX-ray1.85G/M1-173[»]
    1UC4X-ray1.80G/M1-173[»]
    1UC5X-ray2.30G/M1-173[»]
    3AUJX-ray2.10G/M1-173[»]
    ProteinModelPortaliQ59472.
    SMRiQ59472. Positions 37-173.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ59472.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni75 – 773Phosphate 1 bindingImported
    Regioni75 – 773Phosphate 2 bindingImported

    Phylogenomic databases

    KOiK13920.

    Family and domain databases

    InterProiIPR003207. Ppandiol/glycerol_DeHydtase_su.
    [Graphical view]
    PfamiPF02287. Dehydratase_SU. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018505. Prpndl_dhdrts_sm. 1 hit.
    SUPFAMiSSF47148. SSF47148. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q59472-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTDAIESMV RDVLSRMNSL QGEAPAAAPA AGGASRSARV SDYPLANKHP    50
    EWVKTATNKT LDDFTLENVL SNKVTAQDMR ITPETLRLQA SIAKDAGRDR 100
    LAMNFERAAE LTAVPDDRIL EIYNALRPYR STKEELLAIA DDLESRYQAK 150
    ICAAFVREAA TLYVERKKLK GDD 173
    Length:173
    Mass (Da):19,173
    Last modified:November 1, 1996 - v1
    Checksum:i0B8602E39B38ECD0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP008841 Genomic DNA. Translation: AIE72072.1.
    D45071 Genomic DNA. Translation: BAA08101.1.
    PIRiC56111.
    RefSeqiYP_005016277.1. NC_016612.1.

    Genome annotation databases

    GeneIDi11660427.
    KEGGikox:KOX_01465.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP008841 Genomic DNA. Translation: AIE72072.1 .
    D45071 Genomic DNA. Translation: BAA08101.1 .
    PIRi C56111.
    RefSeqi YP_005016277.1. NC_016612.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DIO X-ray 2.20 G/M 1-173 [» ]
    1EEX X-ray 1.70 G/M 1-173 [» ]
    1EGM X-ray 1.85 G/M 1-173 [» ]
    1EGV X-ray 1.75 G/M 1-173 [» ]
    1IWB X-ray 1.85 G/M 1-173 [» ]
    1UC4 X-ray 1.80 G/M 1-173 [» ]
    1UC5 X-ray 2.30 G/M 1-173 [» ]
    3AUJ X-ray 2.10 G/M 1-173 [» ]
    ProteinModelPortali Q59472.
    SMRi Q59472. Positions 37-173.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q59472. 2 interactions.
    MINTi MINT-7997129.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11660427.
    KEGGi kox:KOX_01465.

    Phylogenomic databases

    KOi K13920.

    Miscellaneous databases

    EvolutionaryTracei Q59472.

    Family and domain databases

    InterProi IPR003207. Ppandiol/glycerol_DeHydtase_su.
    [Graphical view ]
    Pfami PF02287. Dehydratase_SU. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018505. Prpndl_dhdrts_sm. 1 hit.
    SUPFAMi SSF47148. SSF47148. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, sequencing, and expression of the genes encoding adenosylcobalamin-dependent diol dehydrase of Klebsiella oxytoca."
      Tobimatsu T., Hara T., Sakaguchi M., Kishimoto Y., Wada Y., Isoda M., Sakai T., Toraya T.
      J. Biol. Chem. 270:7142-7148(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: ATCC 8724Imported.
    2. "A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis: X-ray structure of diol dehydratase."
      Shibata N., Masuda J., Tobimatsu T., Toraya T., Suto K., Morimoto Y., Yasuoka N.
      Structure 7:997-1008(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).
    3. "How a protein generates a catalytic radical from coenzyme B(12): X-ray structure of a diol-dehydratase-adeninylpentylcobalamin complex."
      Masuda J., Shibata N., Morimoto Y., Toraya T., Yasuoka N.
      Structure 8:775-788(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).
    4. "Substrate-induced conformational change of a coenzyme B12-dependent enzyme: crystal structure of the substrate-free form of diol dehydratase."
      Shibata N., Masuda J., Morimoto Y., Yasuoka N., Toraya T.
      Biochemistry 41:12607-12617(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
    5. "Structural rationalization for the lack of stereospecificity in coenzyme B12-dependent diol dehydratase."
      Shibata N., Nakanishi Y., Fukuoka M., Yamanishi M., Yasuoka N., Toraya T.
      J. Biol. Chem. 278:22717-22725(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
    6. "Redesign of coenzyme B(12) dependent diol dehydratase to be resistant to the mechanism-based inactivation by glycerol and act on longer chain 1,2-diols."
      Yamanishi M., Kinoshita K., Fukuoka M., Saito T., Tanokuchi A., Ikeda Y., Obayashi H., Mori K., Shibata N., Tobimatsu T., Toraya T.
      FEBS J. 279:793-804(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
    7. "Whole Genome Sequence of Klebsiella oxytoca M1."
      Shin S.H., Um Y., Cho S., Kim J., Roh H., Yang K.-S.
      Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: M1Imported.

    Entry informationi

    Entry nameiQ59472_KLEOX
    AccessioniPrimary (citable) accession number: Q59472
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3